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Bioactive Poly(Arsenic) Compounds

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Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 54))

Abstract

An overview of the biological activities of arsenic compounds containing more than one arsenic atom in their molecular structure is presented. This contribution covers the literature of the last 10–12 years concerning the in vitro and in vivo studies on arsenic species. They include inorganic oxides and sulfides, already employed for a long time in traditional Chinese medicine and currently investigated against hematological or solid malignancies, with arsenic trioxide clinically used in the treatment of acute promyelocytic leukemia. Chemical and biological aspects on the marine product arsenicin A, representing the first and only organic polyarsenical isolated from Nature, have also been reviewed, pointing out the characterization of its C3H6As4O3 molecular structure by experimental and theoretical vibrational spectroscopies, the potent antimicrobial activities, and the promising perspectives as an antitumor agent.

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Abbreviations

AML:

Acute myeloid leukemia

APCI:

Atmospheric pressure chemical ionization

APL:

Acute promyelocytic leukemia

ATL:

Adult T-cell leukemia

Bcl-xl:

B-cell lymphoma-extra large

CML:

Chronic myelogenous leukemia

DFT:

Density functional theory

EI:

Electron impact

FDA:

Food and drug administration

Hh:

Hedgehog

HTLV-I:

Human T-cell leukemia virus type I

HPV:

Human papillomavirus

IR:

Infrared

JNK:

Jun N-terminal kinase

MS:

Mass spectrometry

NMR:

Nuclear magnetic resonance

PML:

Promyelocytic leukemia

RAR:

Retinoic acid receptor

ROS:

Reactive oxygen species

SAR:

Structure-activity relationship

SDS:

Sodium dodecyl sulfate

SUMO:

Small ubiquitin-like modifier

SUV:

Small unilamellar vesicles

TLC:

Thin layer chromatography

UV:

Ultraviolet

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Correspondence to Ines Mancini .

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To my father Giacomo (1926–2001), with love and gratefully.

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© 2013 Springer-Verlag Berlin Heidelberg

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Mancini, I., Defant, A. (2013). Bioactive Poly(Arsenic) Compounds. In: Müller, W., Wang, X., Schröder, H. (eds) Biomedical Inorganic Polymers. Progress in Molecular and Subcellular Biology, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41004-8_7

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