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Pathologic Staging

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Biliary Tract and Gallbladder Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Pathologic staging of resected cancer specimens is critical in predicting patient outcome and guiding treatment decisions. This chapter will outline the current criteria for pathologic staging of carcinomas of the gallbladder, extrahepatic bile ducts, and ampulla of Vater based on the TNM staging scheme published by the American Joint Committee on Cancer (AJCC). The chapter will also discuss recent changes in the TNM and overall staging criteria based on the seventh edition of the AJCC staging manual. In order to understand pathologic staging, a brief description of normal anatomy and background cancer predisposing conditions will be provided. Finally, important pathologic features other than the TNM stage, which can be valuable predictors of cancer outcome, including tumor macroscopic features, histologic subtype, histologic grade, perineural invasion, angiolymphatic invasion, and resection margin status, will also be discussed.

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  1. Division of Anatomic Pathology, Mayo Clinic, Hilton 11, 200 1st St. SW, Rochester, MN, 55905, USA

    Taofic Mounajjed & Tsung-Teh Wu

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  1. Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland, USA

    Joseph M. Herman

  2. Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA

    Timothy M. Pawlik

  3. Department of Radiation Oncology, Oregon Health and Science University, Portland, Oregon, USA

    Charles R. Thomas, Jr.

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Mounajjed, T., Wu, TT. (2014). Pathologic Staging. In: Herman, J., Pawlik, T., Thomas, Jr., C. (eds) Biliary Tract and Gallbladder Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40558-7_6

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