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PET and SPECT in Psychiatry pp 371–395Cite as

Neurobiology of Posttraumatic Stress Disorder: The Role of Nuclear Neuroimaging

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Abstract

Nuclear neuroimaging plays a valuable role in the noninvasive testing of PTSD models. Correlating abnormalities in function with anatomical imaging, much of this work in patients has focused on isolated structures identified in animal-based research on the neurological basis of fear. Progressing from region-based investigations, recent researchers have incorporated more sophisticated methodological techniques such as functional connectivity analysis to investigate network dysfunctions in the disorder. On a more fundamental level, nuclear techniques have the advantage of being able to investigate underlying neurochemical systems and recent studies have provided evidence for dysfunction in various neurotransmitter systems in these patients. Some of the limitations of current research and future directions are discussed.

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Authors and Affiliations

  1. Medical Imaging and Clinical Oncology, Nuclear Medicine Division, Faculty of Health Sciences, Tygerberg Hospital, Stellenbosch University, Francie van Zijlrylaan, Parow, 7500, Cape Town, South Africa

    Alex G. G. Doruyter & James M. Warwick

  2. Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, J-Block, Groote Schuur Hospital, Observatory, Cape Town, South Africa

    Dan J. Stein

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  1. Alex G. G. Doruyter
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  3. James M. Warwick
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Correspondence to Dan J. Stein .

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Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F. J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen (UMCG), Groningen, The Netherlands

    Johan A. den Boer

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Doruyter, A.G.G., Stein, D.J., Warwick, J.M. (2014). Neurobiology of Posttraumatic Stress Disorder: The Role of Nuclear Neuroimaging. In: Dierckx, R., Otte, A., de Vries, E., van Waarde, A., den Boer, J. (eds) PET and SPECT in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40384-2_14

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