Abstract
Urinary tract infection (UTI) is one of the most common bacterial illnesses in febrile infants younger than 60 days of age. It usually involves the upper urinary tract (pyelonephritis) and delay in therapy can lead to permanent renal damage. During early infancy, UTI is more common in boys, and uncircumcised males have the highest rates of UTI. The male-to-female ratio starts reversing by 4–6 months of age, and by 1 year of age, UTI is three times more common in girls than in boys. In febrile young infants, the diagnosis of UTI is made during sepsis evaluation as there are no specific symptoms or signs of UTI at this age. All febrile newborns <29 days of age and ill appearing 29–60 days old, undergoing sepsis evaluation (that must include urinalysis and culture), are hospitalized and treated with intravenous antibiotics until completion of sepsis work-up. Those with uncomplicated UTI are treated for 10–14 days and part of therapy can be completed with oral antibiotics as outpatient.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alon U, Davidai G, Berant M et al (1987) Five-year survey of changing patterns of susceptibility of bacterial uropathogens to trimethoprim-sulfamethoxazole and other antimicrobial agents. Antimicrob Agents Chemother 31:126–128
Alon US, Ganapathy S (1999) Should renal ultrasonography be done routinely in children with first urinary tract infection? Clin Pediatr 38:21–25
Bachur R (2000) Nonresponders: prolonged fever among infants with urinary tract infections. Pediatrics 105:e59–e62
Bachur R, Caputo GL (1995) Bacteremia and meningitis among infants with urinary tract infections. Pediatr Emerg Care 11:280–284
Bauchner H, Phillip B, Dashefsky B et al (1987) Prevalence of bacteriuria in febrile children. Pediatr Infect Dis J 6:239–242
Buys H, Pead L, Hallett R et al (1994) Suprapubic aspiration under ultrasound guidance in children with fever of undiagnosed cause. Br Med J 308:690–692
Cerwinka WH, Kirsch AJ (2010) Magnetic resonance urography in pediatric urology. Curr Opin Urol 20:323–329
Chan YL, Chan KW, Yeung CK et al (1999) Potential utility of MRI in the evaluation of children at risk of renal scarring. Pediatr Radiol 29:856–862
Clinical Practice Guideline (2011) Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics 128:595–610
Craig J, Simpson J, Williams G (2009) Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med 361(18):1748–1759
Crain EF, Gershel JC (1990) Prevalence of urinary tract infection in febrile infants younger than 8 weeks of age. Pediatrics 86:363–367
Djojohadipringgo S, Abdul Hamid RH, Thahir S et al (1976) Bladder puncture in newborns: a bacteriological study. Paediatr Indones 16:527–534
Doré-Bergeron MJ, Gauthier M, Chevalier I et al (2009) Urinary tract infections in 1- to 3- month old infants: ambulatory treatment with intravenous antibiotics. Pediatrics 124:16–22
El-Naggar W, Yiu A, Mohamed A et al (2010) Comparison of pain during two methods of urine collection in preterm infants. Pediatrics 125:1224–1229
Fernandez-Menendez JM, Malaga S, Matesanz JL et al (2003) Risk factors in the development of early technetium-99m dimercaptosuccinic acid renal scintigraphy lesions during first urinary tract infection in children. Acta Paediatr 92:21–26
Garin EH, Olavarria F, Araya C et al (2007) Diagnostic significance of clinical and laboratory findings to localize site of urinary infection. Pediatr Nephrol 22:1002–1006
Garin EH, Olavarria F, Garcia N et al (2006) Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics 117(3):626–632
Gaspari RJ, Dickson E, Karlowsky J et al (2005) Antibiotic resistance trends in pediatric uropathogens. Int J Antimicrob Agents 26:267–271
Gochman RF, Karasic RB, Heller MB (1991) Use of portable ultrasound to assist urine collection by suprapubic aspiration. Ann Emerg Med 20:631–635
Grattan-Smith JD, Little SB, Jones RA (2008) Evaluation of reflux nephropathy, pyelonephritis and renal dysplasia. Pediatr Radiol 38:s83–s105
Hellerstein S, Alon U, Warady BA (1992) Letter. Urinary screening tests. J Pediatr Infect Dis 11:56–57
Hoberman A, Chao HP, Keller DM et al (1993) Prevalence of urinary tract infection in febrile infants. J Pediatr 123:17–23
Hoberman A, Charron M, Hickey RW et al (2003) Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med 348:195–202
Hoberman A, Winberg J, Roberts KB et al (1994) Pyuria and bacteriuria in urine specimens obtained by catheter from young children with fever. J Pediatr 124:513–519
Jahnukainen T, Honkinen O, Ruuskanen O et al (2006) Ultrasonography after the first febrile urinary tract infection in children. Eur J Pediatr 165:556–559
Jodal U (1987) The natural history of bacteriuria in childhood. Infect Dis Clin N Am 1:713–729
Jones RG, Bass JW (1993) Febrile children with no focus of infection: a survey of their management by primary care physicians. Pediatr Infect Dis J 12:179–183
Kass E (1956) Asymptomatic infections of the urinary tract. Trans Assoc Am Phys 69:56–64
Keren R (2007) Imaging and treatment strategies for children after first urinary tract infection. Curr Opin Pediatr 19:705–710
Klar A, Hurvitz H, Berkun Y et al (1996) Focal bacterial nephritis (lobar nephronia) in children. J Pediatr 128:850–853
Kozer E, Rosenbloom E, Goldman D et al (2006) Pain in infants who are younger than 2 months during suprapubic aspiration and transurethral bladder catheterization: a randomized controlled study. Pediatrics 118:e51–e56
Leong YY, Tan KW (1976) Bladder aspiration for diagnosis of urinary tract infection in infants and young children. J Singapore Paediatr Soc 18:43–47
Lowe LH, Patel MN, Gatti JM et al (2004) Utility of follow-up renal sonography in children with vesicoureteral reflux and normal initial sonogram. Pediatrics 113:548–550
Majd M, Rushton HG, Jantausch B et al (1991) Relationship among vesicoureteral reflux, P-fimbriated Escherichia coli, and acute pyelonephritis in children with febrile urinary tract infection. J Pediatr 119:578–585
Merrick MV, Uttley WS, Wild SR (1980) The detection of pyelonephritic scarring in children by radioisotope imaging. Br J Radiol 53:544–556
Miller T, Phillips S (1981) Pyelonephritis: the relationship between infection, renal scarring, and antimicrobial therapy. Kidney Int 19:654–662
Montini G, Rigon L, Zucchetta P et al (2008) Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial. Pediatrics 122(5):1064–1071
Montini G, Zucchetta P, Tomasi L et al (2009) Value of imaging studies after a first febrile urinary tract infection in young children: data from Italian renal infection study I. Pediatrics 123:e239–e245
Mori R, Lakhanpaul M, Verrier-Jones K (2007) Diagnosis and management of urinary tract infection in children: summary of NICE guidance. Br Med J 335:395–397
Nuutinen M, Uhari M (2001) Recurrence and follow-up after urinary tract infection under the age of 1 year. Pediatr Nephrol 16:69–72
Pecile P, Miorin E, Romanello C et al (2004) Procalcitonin: a marker of severity of acute pyelonephritis among children. Pediatrics 114:e249–e254
Pennesi M, Travan L, Peratoner L et al (2008) Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial. Pediatrics 121(6):e1489–e1494
Pitetti RD, Choi S (2002) Utility of blood cultures in febrile children with UTI. Am J Emerg Med 20:271–274. doi:10.1053/ajem.2002.33786
Plos K, Connell H, Jodal U et al (1995) Intestinal carriage of P fimbriated Escherichia coli and the susceptibility to urinary tract infection in young children. J Infect Dis 171:625–631
Pryles CV, Atkin MD, Morese TS et al (1959) Comparative bacteriologic study of urine obtained from children by percutaneous suprapubic aspiration of the bladder and by catheter. Pediatrics 24:983–991
Pylkkänen J, Vilska J, Koskimies O (1981) The value of level diagnosis of childhood urinary tract infection in predicting renal injury. Acta Paediatr Scand 70:879–883
Roberts KB, Charney E, Sweren RJ et al (1983) Urinary tract infection in infants with unexplained fever: a collaborative study. J Pediatr 103:864–867
Roussey-Kesler G, Gadjos V, Idres N et al (2008) Antibiotic prophylaxis for the prevention of recurrent urinary tract infection in children with low grade vesicoureteral reflux: results from a prospective randomized study. J Urol 179(2):674–679
Schnadower D, Kuppermann N, Macias CG et al (2010) Febrile infants with urinary tract infections at very low risk for adverse events and bacteremia. Pediatrics 126:1074–1083
Schoen EJ (2005) Circumcision for preventing urinary tract infections in boys: North American view. Arch Dis Child 90:772–773
Schoen EJ, Colby CJ, Ray GT (2000) Newborn circumcision decreases incidence and costs of urinary tract infections during the first year of life. Pediatrics 105:789–793
Shah SS, Zorc JJ, Levine DA et al (2008) Sterile cerebrospinal fluid pleocytosis in young infants with urinary tract infections. J Pediatr 153:290–292
Shaikh N, Ewing AL, Bhatnagar S et al (2010) Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics 126:1084–1091
Shaikh N, Morone NE, Bost JE et al (2008) Prevalence of urinary tract infection in childhood. Pediatr Infect Dis J 27:302–308
Sheu JN, Meng-Chi C, Sun-Long C et al (2007) Urine interleukin-1β in children with acute pyelonephritis and renal scarring. Nephrology 12:487–493
Singh-Grewal D, Macdessi J, Craig J (2005) Circumcision for the prevention of urinary tract infection in boys: a systematic review of randomized trials and observational studies. Arch Dis Child 90:853–858
Skoog SJ, Peters CA, Arant BS et al (2010) Pediatric vesicoureteral reflux guidelines panel summary report: Clinical Practice Guidelines for screening siblings of children with vesicoureteral reflux and neonates/infants with prenatal hydronephrosis. J Urol 184:1145–1151
Smellie JM, Poulton A, Prescod NP (1994) Retrospective study of children with renal scarring associated with reflux and urinary infection. Br Med J 308:1193–1196
Spencer JD, Schwaderer AL, DiRosario JD et al (2011) Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract. Kidney Int 80:174–180
Sreenarasimhaiah S, Hellerstein S (1998) Urinary tract infections per se do not cause end-stage kidney disease. Pediatr Nephrol 12:210–213
Stamm WE (1983) Measurement of pyuria and its relation to bacteriuria. Am J Med 75:53–58
Steele BT, Petrou C, DeMaria J (1990) Renal abscess in children. Urology 36:325–328
Visser VE, Hall RT (1979) Urine culture in the evaluation of suspected neonatal sepsis. J Pediatr 94:635–638
Wettergren B, Jodal U (1990) Spontaneous clearance of asymptomatic bacteriuria in infants. Acta Paediatr Scand 79:300–304
Wettergren B, Jodal U, Jonasson G (1985) Epidemiology of bacteriuria during the first year of life. Acta Paediatr Scand 74:925–933
Winberg J, Andersen HJ, Bergstrom T (1974) Epidemiology of symptomatic urinary tract infection in childhood. Acta Paediatr Scand 252(Suppl):1–20
Winter AL, Hardy BE, Alton DJ et al (1983) Acquired renal scars in children. J Urol 129:1190–1194
Wisewell TE, Hachey WE (1993) Urinary tract infections and the uncircumcised state: an update. Clin Pediatr 32:130–134
Zamir G, Sakran W, Horowitz Y et al (2004) Urinary tract infection: is there a need for routine renal ultrasonography? Arch Dis Child 89:466–468
Zhanel GG, Hisanaga TL, Laing NM et al (2005) Antibiotic resistance in outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA). Int J Antimicrob Agents 26:380–388
Zorc JJ, Levin DA, Platt SL et al (2005) Clinical and demographic factors associated with urinary tract infection in young febrile infants. Pediatrics 116:644–648
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Chadha, V., Alon, U.S. (2014). Neonatal Urinary Tract Infection. In: Chishti, A., Alam, S., Kiessling, S. (eds) Kidney and Urinary Tract Diseases in the Newborn. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39988-6_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-39988-6_9
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-39987-9
Online ISBN: 978-3-642-39988-6
eBook Packages: MedicineMedicine (R0)