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Immunology of Aging pp 37–45Cite as

A Role for Epigenetic Modulation of the Innate Immune Response During Aging

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Abstract

The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty.

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Acknowledgments

Funding is gratefully acknowledged from the following sources BBSRC (JWK); BBSRC (SJB); Alzheimer’s Research UK (IHKD); FP7 MARK-AGE (EU FP7 Large-scale integrating Project HEALTH-F4-2008-2008800 (CRD); COST CM1001 and BM1203 (HRG).

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Authors and Affiliations

  1. Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK

    Justin W. Killick BSc, Stuart J. Bennett PhD, Irundika H. K. Dias PhD, Christopher R. Dunston PhD & Helen R. Griffiths PhD

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  1. Justin W. Killick BSc
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  2. Stuart J. Bennett PhD
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  3. Irundika H. K. Dias PhD
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  4. Christopher R. Dunston PhD
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  5. Helen R. Griffiths PhD
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Corresponding author

Correspondence to Helen R. Griffiths PhD .

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Editors and Affiliations

  1. Department of Immunology, Tehran University of Medical Sciences School of Medicine, Tehran, Iran

    Ahmad Massoud

  2. Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

    Nima Rezaei

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Killick, J.W., Bennett, S.J., Dias, I.H.K., Dunston, C.R., Griffiths, H.R. (2014). A Role for Epigenetic Modulation of the Innate Immune Response During Aging. In: Massoud, A., Rezaei, N. (eds) Immunology of Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39495-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-39495-9_4

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