Abstract
Other abnormal substances besides amyloid may infiltrate glomeruli and cause significant dysfunction. Certain glomerular diseases are defined by ultrastructural features of protein deposits. While typical immune complex electron dense deposits have a uniform appearance, some disorders are characterized by an organized substructure to infiltrating proteins. These include cryoglobulinemia and lupus nephritis among others. The two discussed below were described within a few years of one another in the 1970–1980s and, for some time, were considered to be variants of the same disease.
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Fogo A, Qureshi N, Horn RG (1993) Morphologic and clinical features of fibrillary glomerulonephritis versus immunotactoid glomerulopathy. Am J Kidney Dis 22:367–377
Ferrario F, Schiaffino E, Boeri R (1998) Fibrillary and immunotactoid glomerulopathies. Ren Fail 20:801–808
Rostagno A, Vidal R, Kumar A et al (1996) Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes. Am J Kidney Dis 28:676–684
Rosenstock JL, Markowitz GS, Valeri AM, Sacchi G, Appel GB, D’Agati VD (2003) Fibrillary and immunotactoid glomerulonephritis: distinct entities with different clinical and pathologic features. Kidney Int 63:1450–1461
Rosenman E, Eliakim M (1997) Nephrotic syndrome associated with amyloid-like glomerular deposits. Nephron 18:301–308
Adeya OA, Sethi S, Rennke HG (2001) Fibrillary glomerulonephritis: a report of 2 cases with extensive glomerular and tubular deposits. Hum Pathol 32:660–663
Masson RG, Rennke HG, Gottlieb MN (1992) Pulmonary hemorrhage in a patient with fibrillary glomerulonephritis. N Engl J Med 326:36–39
Nasr SH, Valeri AM, Cornell LD, Fidler ME, Sethi S, Leung N, Fervenza FC (2011) Fibrillary glomerulonephritis: a report of 66 cases from a single institution. Clin J Am Soc Nephrol 6:775–784
Pronovost PH, Brady HR, Gunning ME, Espinoza O, Rennke HG (1996) Clinical features, predictors of disease progression and results of renal transplantation in fibrillary/immunotactoid glomerulopathy. Nephrol Dial Transplant 11:837–842
Samaniego M, Nadasdy GM, Laszik Z, Nadasdy T (2001) Outcome of renal transplantation in fibrillary glomerulonephritis. Clin Nephrol 55:159–166
Korbet SM, Schwartz MM, Lewis EJ (1991) Immunotactoid glomerulopathy. Am J Kidney Dis 17:247–257
Bridoux F, Hugue V, Coldefy O, Goujon JM, Bauwens M, Sechet A, Preud’Homme JL, Touchard G (2002) Fibrillary glomerulonephritis and immunotactoid (microtubular) glomerulopathy are associated with distinct immunologic features. Kidney Int 62:1764–1775
Korbet SM, Schwartz MM, Lewis EJ (1994) The fibrillary glomerulopathies. Am J Kidney Dis 23:751–765
Schwartz MM (1993) Immunotactoid glomerulopathy. The case for Occam’s razor. Am J Kidney Dis 22:446–447
Nasr SH, Fidler ME, Cornell LD, Leung N, Cosio FG, Sheikh SS, Amir AA, Vrana JA, Theis JD, Dogan A, Sethi S (2012) Immunotactoid glomerulopathy: clinicopathologic and proteomic study. Nephrol Dial Transplant 27:4137–4146
Alpers CE, Kowalewska J (2008) Fibrillary glomerulonephritis and immunotactoid glomerulopathy. J Am Soc Nephrol 19:34–37
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Fogo, A.B., Cohen, A.H., Colvin, R.B., Jennette, J.C., Alpers, C.E. (2014). Other Diseases with Organized Deposits. In: Fundamentals of Renal Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39080-7_19
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