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International Work-Conference on the Interplay Between Natural and Artificial Computation

IWINAC 2013: Natural and Artificial Computation in Engineering and Medical Applications pp 131–139Cite as

Results on a Lattice Computing Based Group Analysis of Schizophrenic Patients on Resting State fMRI

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Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 7931))

Abstract

We work on the definition of Lattice Computing approach to identify functional networks in resting state fMRI data (rsfMRI) looking for biomarkers of cognitive or neurodegenerative diseases. The approach uses Lattice Auto-Associative Memories (LAAM) to compute a reduced ordering h-function that can be thresholded or processed by morphological operators for network detection. Group analysis is performed on the templates corresponding to each class of subjects computed by averaging their spatially normalized rsfMRI data. We inspect the Tanimoto coefficients computing the similarity between compared networks to decide the appropriate threshold. Results on a dataset of healthy controls, schizophrenia patients with and without auditory hallucinations show that the approach is able to find functionally connected cluster differences discriminating the subjects suffering auditory hallucination.

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Authors and Affiliations

  1. Grupo de Inteligencia Computacional (GIC), Universidad del País Vasco (UPV/EHU), San Sebastian, Spain

    Darya Chyzhyk & Manuel Graña

Authors
  1. Darya Chyzhyk
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  2. Manuel Graña
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Editor information

Editors and Affiliations

  1. Departamento de Electrónica, Tecnología de Computadoras y Proyectos, Universidad Politécnica de Cartagena, Pl. Hospital, 1, 30201, Cartagena, Spain

    José Manuel Ferrández Vicente  & Fco. Javier Toledo Moreo  & 

  2. Departamento de Inteligencia Artificial, Universidad Nacional de Educación a Distancia, E.T.S. de Ingenería Informática, Juan del Rosal, 16, 28040, Madrid, Spain

    José Ramón Álvarez Sánchez  & Félix de la Paz López  & 

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Chyzhyk, D., Graña, M. (2013). Results on a Lattice Computing Based Group Analysis of Schizophrenic Patients on Resting State fMRI. In: Ferrández Vicente, J.M., Álvarez Sánchez, J.R., de la Paz López, F., Toledo Moreo, F.J. (eds) Natural and Artificial Computation in Engineering and Medical Applications. IWINAC 2013. Lecture Notes in Computer Science, vol 7931. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38622-0_14

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  • DOI: https://doi.org/10.1007/978-3-642-38622-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38621-3

  • Online ISBN: 978-3-642-38622-0

  • eBook Packages: Computer ScienceComputer Science (R0)

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