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Systems Biology of Metabolic and Signaling Networks pp 145–162Cite as

Adenylate Kinase Isoform Network: A Major Hub in Cell Energetics and Metabolic Signaling

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Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 16))

Abstract

The adenylate kinase isoform network is integral to the cellular energetic system and a major player in AMP metabolic signaling circuits. Critical in energy state monitoring and stress response, the dynamic behavior of the adenylate kinase network in governing intracellular, nuclear, and extracellular nucleotide signaling processes has been increasingly revealed. New adenylate kinase mutations have been identified that cause severe human disease phenotypes such as reticular dysgenesis associated with immunodeficiency and sensorineural hearing loss and primary ciliary dyskinesia characteristic of chronic obstructive pulmonary disease. The adenylate kinase family comprises nine major isoforms (AK1–AK9), and several subforms with distinct intracellular localization and kinetic properties designed to support specific cellular processes ranging from muscle contraction, electrical activity, cell motility, unfolded protein response, and mitochondrial/nuclear energetics. Adenylate kinase and AMP signaling is necessary for energetic communication between mitochondria, myofibrils, and the cell nucleus and for metabolic programming facilitating stem cell cardiac differentiation and mitochondrial network formation. Moreover, it was discovered that during cell cycle, the AK1 isoform translocates to the nucleus and associates with the mitotic spindle to provide energy for cell division. Furthermore, deletion of Ak2 gene is embryonically lethal, indicating critical significance of catalyzed phosphotransfer in the crowded mitochondrial intracristae and subcellular spaces for ATP export and intracellular distribution. Taken together, new evidence highlights the importance of the system-wide adenylate kinase isoform network and adenylate kinase-mediated phosphotransfer and AMP signaling in cellular energetics, metabolic sensing, and regulation of nuclear and cell cycle processes which are critical in tissue homeostasis, renewal, and regeneration.

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Acknowledgments

This work was supported by National Institutes of Health, Marriott Heart Disease Research Program, Marriott Foundation, and Mayo Clinic. We thank Mayo Graduate School student Jennifer Shing for reading and editing the manuscript.

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Authors and Affiliations

  1. Center for Regenerative Medicine, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA

    Song Zhang, Andre Terzic & Petras Dzeja

  2. Analytical Chemistry, Hacettepe University, Ankara, Turkey

    Emirhan Nemutlu

Authors
  1. Song Zhang
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  2. Emirhan Nemutlu
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  3. Andre Terzic
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  4. Petras Dzeja
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Correspondence to Petras Dzeja .

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Editors and Affiliations

  1. School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

    Miguel A. Aon

  2. Laboratory of Fundamental and Applied Bi, Inserm U1055 and University Joseph Fourier, Grenoble, Grenoble cedex 9, France

    Valdur Saks

  3. Laboratory of Fundamental and Applied Bi, Inserm U1055 and University Joseph Fourier, Grenoble, Grenoble cedex 9, France

    Uwe Schlattner

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Zhang, S., Nemutlu, E., Terzic, A., Dzeja, P. (2014). Adenylate Kinase Isoform Network: A Major Hub in Cell Energetics and Metabolic Signaling. In: Aon, M., Saks, V., Schlattner, U. (eds) Systems Biology of Metabolic and Signaling Networks. Springer Series in Biophysics, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38505-6_6

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