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Results of HDR Prostate Brachytherapy Treatments

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Interstitial Prostate Brachytherapy

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Abstract

Most of the publications deal with retrospective monoinstitutional results or with the statistical analysis of multi-institutional data pools. Although results of prospective nonrandomized studies or retrospective data analysis may be influenced by potential selection bias and inconsistent data analysis, careful presentation can help to understand basic and meaningful trends within the specialty. From the clinical results, HDR brachytherapy combined with external beam radiation offers the best possible outcome for localized high-risk prostate cancer patients. Patients in the low- or intermediate-risk groups may not be disadvantaged by brachytherapy as monotherapy; however, careful selection in the intermediate-risk group is advisory. Experienced teams report 5-year biochemical relapse-free rates (bNED) about 70, 80, and 90 % in the high-, intermediate-, and low-risk groups. Common significant acute toxicities (G2+) are small bowel (15–20 %), bladder reactions (40–50 %), and rectal discharge (35–40 %). Transient hematuria can be observed in 10–17 %. Most frequent late severe toxicities are urethral stricture (4–8 %), gastrointestinal (2–7 %), and erectile dysfunction (20–60 % at 2 years). Results of investigational treatments are also discussed if present in the literature.

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Authors and Affiliations

  1. Interdisciplinary Brachytherapy Unit, University of Lübeck, Ratzeburger Allee 160, D-23562, Lübeck, Germany

    György Kovács

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  1. György Kovács
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Correspondence to György Kovács .

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Editors and Affiliations

  1. Ratzeburger Allee 160, Lübeck, 23538, Germany

    György Kovács

  2. University College London, Mount Vernon Cancer Centre, Rickmansworth Road, London, HA62RN, United Kingdom

    Peter Hoskin

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Kovács, G. (2013). Results of HDR Prostate Brachytherapy Treatments. In: Kovács, G., Hoskin, P. (eds) Interstitial Prostate Brachytherapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36499-0_16

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  • DOI: https://doi.org/10.1007/978-3-642-36499-0_16

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  • Print ISBN: 978-3-642-36498-3

  • Online ISBN: 978-3-642-36499-0

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