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European Instructional Lectures pp 37–48Cite as

New Trends Based on Experimental Results in the Treatment of Sarcoma

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Part of the book series: European Instructional Lectures ((EICL,volume 13))

Abstract

The enduring impasse in the success rate of conventional treatment may be overcome by a critical re-appraisal of conventional research methods and available therapeutic tools, focussing on the complexity of the tumour microenvironment. Current methods do not reproduce the hypoxic, acidic conditions at the tumour site nor the mutual influences of cancer cells with reactive fibroblasts and immune cells. A peculiar feature of these interactions is an increased acidity of the extracellular environment, and this can be exploited for pharmacological therapies targeting the extrusion of protons from the cellular compartments, inducing selective cytotoxic effects on cancer cells, and for a photodynamic approach based on acid-seeking agents, extending the chances of conservative surgery.

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Acknowledgment

Grant support: Ministry of Health (Grant RBAP10447J_004 to N. Baldini), Italian Association for Cancer Research (Grant 11426 to N. Baldini), IOR “5 per mille”.

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Authors and Affiliations

  1. Department of Biomedical and Neuromotor Sciences, University of Bologna, Via di Barbiano 1/10, I-40136, Bologna, Italy

    Nicola Baldini

  2. Orthopaedic Pathophysiology Unit, Istituto Ortopedico Rizzoli, Bologna, Italy

    Nicola Baldini

  3. Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Katsuyuki Kusuzaki

Authors
  1. Nicola Baldini
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  2. Katsuyuki Kusuzaki
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Correspondence to Nicola Baldini .

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Editors and Affiliations

  1. Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, Middlesex, United Kingdom

    George Bentley

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Baldini, N., Kusuzaki, K. (2013). New Trends Based on Experimental Results in the Treatment of Sarcoma. In: Bentley, G. (eds) European Instructional Lectures. European Instructional Lectures, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36149-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-36149-4_4

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