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Molecular Imaging pp 513–538Cite as

RGD-Based Molecular Probes for Integrin α v β3 Imaging

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Part of the book series: Advanced Topics in Science and Technology in China ((ATSTC))

Abstract

The cell adhesion molecule integrin α v β3 is an important player in the process of tumor angiogenesis and metastasis. It is expressed on activated endothelial cells as well as some tumor cells. Non-invasive imaging of integrin α v β3 expression would provide a unique means of characterizing the biological aggressiveness of a malignant tumor in an individual patient. In this chapter, we will summarize the current development and applications of arginine-glycine-aspartic acid (RGD)- based molecular probes for molecular imaging of integrin α v β3 imaging using either a single molecular imaging modality (magnetic resonance imaging, ultrasound, optical, single photon emission computed tomography, and positron emission tomography) or a combination of the different modalities. The strategies that are currently used to optimize the RGD probes will be briefly introduced.

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  1. Medical Isotopes Research Center, Peking University, Beijing, 100191, China

    Fan Wang & Zhaofei Liu

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Wang, F., Liu, Z. (2013). RGD-Based Molecular Probes for Integrin α v β3 Imaging. In: Molecular Imaging. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34303-2_15

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