Abstract
The term “cosmeceuticals”, suggested by Kligman more than 20 years ago, refers to topical products that lie in a gray zone where they are viewed as having both pharmaceutical and cosmetic properties [1]. Although the neologism was innovative and relevant, it was rejected from the US Food, Drug, and Cosmetic Act that, according to the 1938s US Congress, labels as drug every substance for use in the diagnosis, cure, treatment or prevention of disease, and as cosmetic any product intended for beautifying and promoting attractiveness. In spite of this, the term cosmeceuticals has recently been gaining increasing popularity, as the term cosmetic seems to be restrictive for those substances that have druglike beneficial effects. On the other hand, the “cosmeceuticals” concept has caused a lot of confusion, because of similar neologisms such as neutraceuticals and/or neoceuticals. Actually, in USA and Canada, most cosmeceuticals are regulated as over the counter (OTC) products, while in Europe they are considered as cosmetics. Only in Japan, a new class of products, called quasi-drugs, has been created [2].
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References
Kligman AM (1993) Why cosmeceuticals? Cosmet Toilet 108:37–38
Comparative study on cosmetics legislation in the EU and other principal markets with special attention to so-called Borderline products. Available at: http://ec.europa.eu/enterprise/newsroom/cf/itemdetail.cfm?item_id=3620. Accessed August 2004, Risk and Policy Analysts Limited. www.rpaltd.co.uk
Choi CM, Berson DS (2006) Cosmeceuticals. Semin Cutan Med Surg 25(3):163–168
Thornfeldt C (2005) Cosmeceuticals containing herbs: fact, fiction, and future. Dermatol Surg 31(7 Pt 2):873–880
Bellemere G, Stamatas GN, Bruere V, Bertin C, Issachar N, Oddos T (2009) Antiaging action of retinol: from molecular to clinical. Skin Pharmacol Physiol 22(4):200–209
Sorg O, Kuenzli S, Kaya G, Saurat JH (2005) Proposed mechanisms of action for retinoid derivatives in the treatment of skin aging. J Cosmet Dermatol 4(4):237–244
Kafi R, Kwak HS, Schumacher WE et al (2007) Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol 143(5):606–612
Sorg O, Antille C, Kaya G, Saurat JH (2006) Retinoids in cosmeceuticals. Dermatol Ther 19(5):289–296
Vienne MP, Ochando N, Borrel MT, Gall Y, Lauze C, Dupuy P (1999) Retinaldehyde alleviates rosacea. Dermatology 199(Suppl 1):53–56
Dreno B, Castell A, Tsankov N et al (2009) Interest of the association retinaldehyde/glycolic acid in adult acne. J Eur Acad Dermatol Venereol 23:529–532
Dreno B, Katsambas A, Pelfini C, Plantier D, Jancovici E, Ribet V, Nocera T, Morinet P, Khammari A (2007) Combined 0.1 % retinaldehyde/6 % glycolic acid cream in prophylaxis and treatment of acne scarring. Dermatology 214(3):260–267
Namazi MR (2007) Nicotinamide in dermatology: a capsule summary. Int J Dermatol 46:1229–1231
Veraldi S, Micali G, Barbareschi M, Tedeschi A, Schianchi R (2012) Topical nicotinamide in acne: a critical review. Eur J Acne Relat Dis 3(2):21–26
Kim N, Yang A, Kirsner RS (2008) Topical nicotinamide prevents UV immunosuppression. J Invest Dermatol 128:250
Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B et al (2011) A double-blind, randomized clinical trial of niacinamide 4 % versus hydroquinone 4 % in the treatment of melasma. Dermatol Res Pract 2011:379173
Niren NM (2006) Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis 77(1 Suppl):11–16
Yiasemides E, Sivapirabu G, Halliday GM, Park J, Damian DL (2009) Oral nicotinamide protects against ultraviolet radiation-induced immunosuppression in humans. Carcinogenesis 30(1):101–105
Bissett DL, Miyamoto K, Sun P, Li J, Berge CA (2004) Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int J Cosmet Sci 26(5):231–238
Bissett DL, Oblong JE, Berge CA (2005) Niacinamide: a B vitamin that improves aging facial skin appearance. Dermatol Surg 31:860–865
Burke KE (2007) Interaction of vitamins C and E as better cosmeceuticals. Dermatol Ther 20(5):314–321
Ando S, Ando O, Suemoto Y, Mishima Y (1993) Tyrosinase gene transcription and its control by melanogenic inhibitors. J Invest Dermatol 100(2 Suppl):150S–155S
Thiele JJ, Hsieh SN, Ekanayake-Mudiyanselage S (2005) Vitamin E: critical review of its current use in cosmetic and clinical dermatology. Dermatol Surg 31(7 Pt 2):805–813
Darr D, Dunston S, Faust H, Pinnell S (1996) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants. Acta Derm Venereol 76(4):264–268
Veraldi S, Romani S (2012) Vitamina E. In: Berardesca E, Celleno L, Manfredini S, Veraldi S (eds) Le vitamine topiche a, C, E: biologia, dermatologia, cosmetologia (I ristampa). Cluster, Torino, pp 63–78
Burke KE, Clive J, Combs GF Jr, Commisso J, Keen CL, Nakamura RM (2000) Effects of topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice. Nutr Cancer 38(1):87–97
Lupo MP (2001) Antioxidants and vitamins in cosmetics. Clin Dermatol 19(4):467–473
Wada N, Wakami H, Konishi T, Matsugo S (2009) The degradation and regeneration of alpha-lipoic acid under the irradiation of UV light in the existence of homocysteine. J Clin Biochem Nutr 44(3):218–222
Kaikkonen J, Tuomainen TP, Nyyssonen K, Salonen JT (2002) Coenzyme Q10: absorption, antioxidative properties, determinants, and plasma levels. Free Radic Res 36(4):389–397
De Luca C, Kharaeva Z, Raskovic D, Pastore P, Luci A, Korkina L (2012) Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral mucocutaneous infections. Nutrition 28(5):509–514
McDaniel D, Neudecker B, Dinardo J, Lewis J 2nd, Maibach H (2005) Clinical efficacy assessment in photodamaged skin of 0.5 % and 1.0 % idebenone. J Cosmet Dermatol 4(3):167–173
Natkunarajah J, Ostlere L (2008) Allergic contact dermatitis to idebenone in an over-the-counter anti-ageing cream. Contact Dermatitis 58(4):239
Sasseville D, Moreau L, Al-Sowaidi M (2007) Allergic contact dermatitis to idebenone used as an antioxidant in an anti-wrinkle cream. Contact Dermatitis 56(2):117–118
Chen L, Judy Y, Steven QW (2012) The role of antioxidants in photoprotections: a critical review. J Am Acad Dermatol 67(5):1013–1024
Kim HH, Cho S, Lee S, Kim KH, Cho KH, Eun HC, Chung JH (2006) Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo. J Lipid Res 47:921–930
Winther B, Hoem N, Berge K, Reubsaet L (2011) Elucidation of phosphatidylcholine composition in krill oil extracted from Euphausia superba. Lipids 46(1):25–36
Tedeschi A, Umana M, D’Agata O, Dall’Oglio F, Nardone B, Micali G (2007) Valutazione dell’efficacia di un integratore alimentare associato ad una emulsione anti eta’ rispetto al solo trattamento topico: studio clinico su 40 donne in pre e/o menopausa. J Plast Dermatol 3:1–7
Tandy S, Chung RW, Wat E, Kamili A, Berge K, Griinari M, Cohn JS (2009) Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 57(19):9339–9345
Maki KC, Reeves MS, Farmer M, Griinari M, Berge K, Vik H, Hubacher R, Rains TM (2009) Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr Res 29(9):609–615
Ierna M, Kerr A, Scales H, Berge K, Griinari M (2010) Supplementation of diet with krill oil protects against experimental rheumatoid arthritis. BMC Musculoskelet Disord 11:136
Lin JK, Liang YC, Lin-Shiau SY (1999) Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochem Pharmacol 58(6):911–915
Chiu PC, Chan CC, Lin HM, Chiu HC (2007) The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. J Cosmet Dermatol 6(4):243–249
Martinez-Ferrer M, Afshar-Sherif AR, Uwamariya C, de Crombrugghe B, Davidson JM, Bhowmick NA (2009) Dermal transforming growth factor-{beta} responsiveness mediates wound contraction and epithelial closure. Am J Pathol 176:98–107
Fitzpatrick RE, Mehta RC (2009) Endogenous growth factors as cosmeceuticals. In: Draelos ZD (ed) Procedures in cosmetic dermatology: cosmeceuticals, 2nd edn. Saunders/Elsevier, Philadelphia, pp 137–143
Fitzpatrick RE, Rostan EF (2003) Reversal of photodamage with topical growth factor: a pilot study. J Cosmet Laser Ther 5:25–34
Alemdaroglu C, Degim Z, Celebi N, Sengezer M, Alomeroglu M, Nacar A (2008) Investigation of epidermal growth factor containing liposome formulation effects on burn wound healing. J Biomed Mater Res A 85(1):271–283
Ryu SH, Moon SY, Yang YJ et al (2009) Recombinant human epidermal growth factor accelerates the proliferation of irradiated human fibroblasts and keratinocytes in vitro and in vivo. J Radiat Res (Tokyo) 50(6):545–552
Kamoun A, Landeau JM, Godeau G et al (1995) Growth stimulation of human skin fibroblasts by elastin-derived peptides. Cell Adhes Commun 3(4):273–281
Lupo MP, Cole AL (2009) Peptides and proteins. In: Draelos ZD (ed) Procedures in cosmetic dermatology: cosmeceuticals, 2nd edn. Saunders/Elsevier, Philadelphia, pp 121–127
Lupo MP (2005) Cosmeceutical peptides. Dermatol Surg 31:832–836
Leyden JJ (2002) Skin care benefits of copper peptide containing facial cream. Presented at the American Academy of Dermatology 60th Annual Meeting; New Orleans
Gutierrez LM, Canaves JM, Ferrer-Montiel AV, Reig JA, Montal M, Viniegra S (1995) A peptide that mimics the carboxy-terminal domain of SNAP-25 blocks Ca(2+)-dependent exocytosis in chromaffin cells. FEBS Lett 372(1):39–43
Gutierrez LM, Viniegra S, Rueda J, Ferrer-Montiel AV, Canaves JM, Montal M (1997) A peptide that mimics the C-terminal sequence of SNAP-25 inhibits secretory vesicle docking in chromaffin cells. J Biol Chem 272(5):2634–2639
Blanes-Mira C, Merino JM, Valera E et al (2004) Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis. J Neurochem 88(1):124–135
Blanes-Mira C, Clemente J, Jodas G et al (2002) A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci 24(5):303–310
Gao XH, Zhang L, Wei H, Chen HD (2008) Efficacy and safety of innovative cosmeceuticals. Clin Dermatol 26(4):367–374
Michaluart P, Masferrer JL, Carothers AM et al (1999) Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 59(10):2347–2352
Chen YJ, Shiao MS, Wang SY (2001) The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anticancer Drugs 12(2):143–149
Huang MT, Ma W, Yen P et al (1996) Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells. Carcinogenesis 17(4):761–765
Baumann LS (2007) Less-known botanical cosmeceuticals. Dermatol Ther 20(5):330–342
Aries MF, Vaissiere C, Pinelli E, Pipy B, Charveron M (2005) Avena Rhealba inhibits A23187-stimulated arachidonic acid mobilization, eicosanoid release, and cPLA2 expression in human keratinocytes: potential in cutaneous inflammatory disorders. Biol Pharm Bull 28(4):601–606
Sur R, Nigam A, Grote D, Liebel F, Southall MD (2008) Avenanthramides, polyphenols from oats, exhibit anti-inflammatory and anti-itch activity. Arch Dermatol Res 300(10):569–574
Al-Waili NS (2003) Topical application of natural honey, beeswax and olive oil mixture for atopic dermatitis or psoriasis: partially controlled, single-blinded study. Complement Ther Med 11(4):226–234
Al-Waili NS (2005) Clinical and mycological benefits of topical application of honey, olive oil and beeswax in diaper dermatitis. Clin Microbiol Infect 11(2):160–163
Al-Waili NS, Saloom KS, Al-Waili TN, Al-Waili AN (2006) The safety and efficacy of a mixture of honey, olive oil, and beeswax for the management of hemorrhoids and anal fissure: a pilot study. ScientificWorldJournal 6:1998–2005
Beauchamp GK, Keast RS, Morel D et al (2005) Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 437(7055):45–46
Zwane RE, Parker A, Kudanga T, Davids LM, Burton SG (2012) Novel, biocatalytically produced hydroxytyrosol dimer protects against ultraviolet-induced cell death in human immortalized keratinocytes. J Agric Food Chem 60(46):11509–11517
Reddy KK, Grossman L, Rogers GS (2011) Common complementary and alternative therapies with potential use in dermatologic surgery: risks and benefits. J Am Acad Dermatol [Epub ahead of print]
Skovgaard GR, Jensen AS, Sigler ML (2006) Effect of a novel dietary supplement on skin aging in post-menopausal women. Eur J Clin Nutr 60(10):1201–1206
Yamakoshi J, Sano A, Tokutake S et al (2004) Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytother Res 18(11):895–899
Lu YP, Lou YR, Li XH et al (2002) Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in mouse skin. Oncol Res 13(2):61–70
Song F, Qureshi AA, Han J (2012) Increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skin. Cancer Res 72(13):3282–3289
Bouzari N, Romagosa Y, Kirsner RS (2009) Green tea prevents skin cancer by two mechanisms. J Invest Dermatol 129(5):1054
Chiu AE, Chan JL, Kern DG, Kohler S, Rehmus WE, Kimball AB (2005) Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg 31(7 Pt 2):855–860
Kidd PM (2009) Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Altern Med Rev 14(3):226–246
Ahmed S, Rahman A, Hasnain A, Lalonde M, Goldberg VM, Haqqi TM (2002) Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic Biol Med 33(8):1097–1105
Kim SJ, Jeong HJ, Lee KM, Myung NY, An NH, Yang WM, Park SK, Lee HJ, Hong SH, Kim HM, Um JY (2007) Epigallocatechin-3-gallate suppresses NF-kappaB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells. J Nutr Biochem 18(9):587–596
Ahmed S, Wang N, Lalonde M, Goldberg VM, Haqqi TM (2004) Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and −13 in human chondrocytes. J Pharmacol Exp Ther 308(2):767–773
Khan N, Mukhtar H (2008) Multitargeted therapy of cancer by green tea polyphenols. Cancer Lett 269(2):269–280
Katiyar S, Elmets CA, Katiyar SK (2007) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair. J Nutr Biochem 18(5):287–296
Katiyar SK, Matsui MS, Elmets CA, Mukhtar H (1999) Polyphenolic antioxidant (−)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Photochem Photobiol 69(2):148–153
Afaq F, Zaid MA, Khan N, Dreher M, Mukhtar H (2009) Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin. Exp Dermatol 18(6):553–561
Aslam MN, Lansky EP, Varani J (2006) Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J Ethnopharmacol 103(3):311–318
Thornfeldt CR (2009) Cosmecutical botanical: part 2. In: Draelos ZD (ed) Procedures in cosmetic dermatology: cosmeceuticals, 2nd edn. Saunders/Elsevier, Philadelphia, pp 77–85
Khanna S, Venojarvi M, Roy S et al (2002) Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic Biol Med 33(8):1089–1096
Docherty JJ, Smith JS, Fu MM, Stoner T, Booth T (2004) Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice. Antiviral Res 61(1):19–26
Chen ML, Li J, Xiao WR et al (2006) Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban 31(5):635–639
Fabbrocini G, Staibano S, De Rosa G et al (2011) Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. Am J Clin Dermatol 12:133–141
Buonocore D, Lazzeretti A, Tocabens P, Nobile V, Cestone E, Santin G, Bottone MG, Marzatico F (2012) Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebocontrolled, double-blind study. Clin Cosmet Investig Dermatol 5:159–165
Draelos ZD (2009) Comeceutical botanicals: part 1. In: Draelos ZD (ed) Procedures in cosmetic dermatology: cosmeceuticals, 2nd edn. Saunders/Elsevier, Philadelphia, pp 69–75
Burke KE (2009) Nutritional antioxidants. In: Draelos ZD (ed) Procedures in cosmetic dermatology: cosmeceuticals, 2nd edn. Saunders/Elsevier, Philadelphia, pp 129–136
Sadick NS (2009) Future cosmeceuticals of dermatologic importance. In: Draelos ZD (ed) Procedures in cosmetic dermatology: cosmeceuticals, 2nd edn. Saunders/Elsevier, Philadelphia, pp 203–208
Izumi T, Saito M, Obata A, Arii M, Yamaguchi H, Matsuyama A (2007) Oral intake of soy isoflavone aglycone improves the aged skin of adult women. J Nutr Sci Vitaminol (Tokyo) 53(1):57–62
Cao C, Li S, Dai X et al (2009) Genistein inhibits proliferation and functions of hypertrophic scar fibroblasts. Burns 35(1):89–97
Barone E, Calabrese V, Mancuso C (2009) Ferulic acid and its therapeutic potential as a hormetin for age-related diseases. Biogerontology 10(2):97–108
Di Domenico F, Perluigi M, Foppoli C et al (2009) Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes. Free Radic Res 43(4):365–375
Han MH, Yoon WK, Lee H et al (2007) Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice. Int Immunopharmacol 7(13):1651–1658
Katiyar SK, Korman NJ, Mukhtar H, Agarwal R (1997) Protective effects of silymarin against photocarcinogenesis in a mouse skin model. J Natl Cancer Inst 89(8):556–566
Bhatia N, Agarwal C, Agarwal R (2001) Differential responses of skin cancer-chemopreventive agents silibinin, quercetin and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. Nutr Cancer 39:292–299
Vicentini FT, Simi TR, Del Ciampo JO et al (2008) Quercetin in w/o microemulsion: in vitro and in vivo skin penetration and efficacy against UVB-induced skin damages evaluated in vivo. Eur J Pharm Biopharm 69(3):948–957
Thangapazham RL, Sharma A, Maheshwari RK (2007) Beneficial role of curcumin in skin diseases. Adv Exp Med Biol 595:343–357
Kulac M, Aktas C, Tulubas F, Uygur R, Kanter M, Erboga M, Ceber M, Topcu B, Ozen OA (2013) The effects of topical treatment with curcumin on burn wound healing in rats. J Mol Histol 44:83–90
Dinkova-Kostova AT, Massiah MA, Bozak RE, Hicks RJ, Talalay P (2001) Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci USA 98(6):3404–3409
Kang G, Kong PJ, Yuh YJ et al (2004) Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells. J Pharmacol Sci 94(3):325–328
Panahi Y, Sahebkar A, Parvin S, Saadat A (2012) A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. Ann Clin Biochem 49(Pt 6):580–588
Reuter S, Eifes S, Dicato M, Aggarwal BB, Diederich M (2008) Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem Pharmacol 76(11):1340–1351
Scapagnini G, Colombrita C, Amadio M et al (2006) Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid Redox Signal 8(3–4):395–403
Joe B, Lokesh BR (1997) Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages. Lipids 32(11):1173–1180
Kurien BT, Singh A, Matsumoto H, Scofield RH (2007) Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug Dev Technol 5(4):567–576
Wagner S, Suter A, Merfort I (2004) Skin penetration studies of Arnica preparations and of their sesquiterpene lactones. Planta Med 70(10):897–903
Seeley BM, Denton AB, Ahn MS, Maas CS (2006) Effect of homeopathic Arnica montana on bruising in face-lifts: results of a randomized, double-blind, placebo-controlled clinical trial. Arch Facial Plast Surg 8(1):54–59
Sawaya ME, Shapiro J (2000) Androgenetic alopecia. New approved and unapproved treatments. Dermatol Clin 18(1):47–61
Srivastava JK, Pandey M, Gupta S (2009) Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life Sci 85(19–20):663–669
Vazquez B, Avila G, Segura D, Escalante B (1996) Antiinflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol 55(1):69–75
Fisher AA (1981) Allantoin: a non-sensitizing topical medicament. Therapeutic effects of the addition of 5 percent allantoin to Vaseline. Cutis 27(3):230–231, 4, 329
Araújo LU, Grabe-Guimarães A, Mosqueira VC, Carneiro CM, Silva-Barcellos NM (2010) Profile of wound healing process induced by allantoin. Acta Cir Bras 25(5):460–466
Izaka KI, Yamada M, Kawano T, Suyama T (1972) Gastrointestinal absorption and antiinflammatory effect of bromelain. Jpn J Pharmacol 22(4):519–534
Ruhl F, Otto H (1965) On the oral therapy of posttraumatic edema and hematomas with the plant proteolytic enzyme bromelain. Therapiewoche 15(11):555–559
Zhang S, Lin ZN, Yang CF, Shi X, Ong CN, Shen HM (2004) Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. Carcinogenesis 25(11):2191–2199
Lesiak K, Koprowska K, Zalesna I, Nejc D, Duchler M, Czyz M (2010) Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro. Melanoma Res 20(1):21–34
Killoran CE, Crawford GH, Pedvis-Leftick A (2007) Two cases of compositae dermatitis exacerbated by moisturizer containing feverfew. Dermatitis 18(4):225–229
Cui Y, Ao M, Li W, Hu J, Yu L (2008) Anti-inflammatory activity of licochalcone A isolated from Glycyrrhiza inflata. Z Naturforsch C 63(5–6):361–365
Weber TM, Ceilley RI, Buerger A et al (2006) Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A. J Cosmet Dermatol 5(3):227–232
Andreassi M, Stanghellini E, Ettorre A, Di Stefano A, Andreassi L (2004) Antioxidant activity of topically applied lycopene. J Eur Acad Dermatol Venereol 18(1):52–55
Böhm F, Edge R, Truscott TG (2012) Interactions of dietary carotenoids with singlet oxygen (1O2) and free radicals: potential effects for human health. Acta Biochim Pol 59(1):27–30
Böhm F, Edge R, Truscott G (2012) Interactions of dietary carotenoids with activated (singlet) oxygen and free radicals: potential effects for human health. Mol Nutr Food Res 56(2):205–216
Rizwan M, Rodriguez-Blanco I, Harbottle A, Birch-Machin MA, Watson RE, Rhodes LE (2011) Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. Br J Dermatol 164(1):154–162
Juge N, Mithen RF, Traka M (2007) Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci 64(9):1105–1127
Talalay P, Fahey JW, Healy ZR et al (2007) Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc Natl Acad Sci USA 104(44):17500–17505
Jakubikova J, Cervi D, Ooi M, Kim K, Nahar S, Klippel S, Cholujova D, Leiba M, Daley JF, Delmore J, Negri J, Blotta S, McMillin DW, Hideshima T, Richardson PG, Sedlak J, Anderson KC, Mitsiades CS (2011) Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma. Haematologica 96(8):1170–1179
Van Scott EJ, Yu RJ (1984) Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids. J Am Acad Dermatol 11(5 Pt 1):867–879
Dainichi T, Ueda S, Imayama S, Furue M (2008) Excellent clinical results with a new preparation for chemical peeling in acne: 30 % salicylic acid in polyethylene glycol vehicle. Dermatol Surg 34(7):891–899
Ejaz A, Raza N, Iftikhar N, Muzzafar F (2008) Comparison of 30 % salicylic acid with Jessner’s solution for superficial chemical peeling in epidermal melasma. J Coll Physicians Surg Pak 18(4):205–208
Kligman D, Kligman AM (1998) Salicylic acid peels for the treatment of photoaging. Dermatol Surg 24(3):325–328
Edison BL, Green BA, Wildnauer RH, Sigler ML (2004) A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen. Cutis 73(2 Suppl):14–17
Bernstein EF, Brown DB, Schwartz MD, Kaidbey K, Ksenzenko SM (2004) The polyhydroxy acid gluconolactone protects against ultraviolet radiation in an in vitro model of cutaneous photoaging. Dermatol Surg 30(2 Pt 1):189–195; discussion 96
Kim H, Choi HR, Kim DS, Park KC (2012) Topical hypopigmenting agents for pigmentary disorders and their mechanisms of action. Ann Dermatol 24(1):1–6
Rendon MI, Gavina JI (2009) Skin lightening agents. In: Draelos ZD (ed) Procedures in cosmetic dermatology: cosmeceuticals, 2nd edn. Saunders/Elsevier, Philadelphia, pp 103–111
Jordaan HF, Van Niekerk DJ (1991) Transepidermal elimination in exogenous ochronosis. A report of two cases. Am J Dermatopathol 13(4):418–424
McGregor D (2007) Hydroquinone: an evaluation of the human risks from its carcinogenic and mutagenic properties. Crit Rev Toxicol 37(10):887–914
Nerya O, Vaya J, Musa R, Izrael S, Ben-Arie R, Tamir S (2003) Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem 51(5):1201–1207
Yokota T, Nishio H, Kubota Y, Mizoguchi M (1998) The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. Pigment Cell Res 11(6):355–361
Lee JW, Ji YJ, Yu MH et al (2009) Antimicrobial effect and resistant regulation of Glycyrrhiza uralensis on methicillin-resistant Staphylococcus aureus. Nat Prod Res 23(2):101–111
Kahn V (1995) Effect of kojic acid on the oxidation of DL-DOPA, norepinephrine, and dopamine by mushroom tyrosinase. Pigment Cell Res 8(5):234–240
Nakagawa M, Kawai K (1995) Contact allergy to kojic acidin skin care products. Contact Dermatitis 32:9–13
Lim YJ, Lee EH, Kang TH et al (2009) Inhibitory effects of arbutin on melanin biosynthesis of alpha-melanocyte stimulating hormone-induced hyperpigmentation in cultured brownish guinea pig skin tissues. Arch Pharm Res 32(3):367–373
Draelos ZD (2008) The cosmeceutical realm. Clin Dermatol 26(6):627–632
Jin YH, Lee SJ, Chung MH et al (1999) Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism. Arch Pharm Res 22(3):232–236
Jin YH, Lee SJ, Chung MH, Park JH, Park YI, Cho TH, Lee SK (1999) Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism. Arch Pharm Res 22(3):232–236
Ertam I, Mutlu B, Unal I, Alper S, Kivçak B, Ozer O (2008) Efficiency of ellagic acid and arbutin in melasma: a randomized, prospective, open-label study. J Dermatol 35(9):570–574
Smith WP (1999) The effects of topical l(+) lactic Acid and ascorbic Acid on skin whitening. Int J Cosmet Sci 21(1):33–40
Kasai K, Yoshimura M, Koga T, Arii M, Kawasaki S (2006) Effects of oral administration of ellagic acid-rich pomegranate extract on ultraviolet-induced pigmentation in the human skin. J Nutr Sci Vitaminol (Tokyo) 52(5):383–388
Yoshimura M, Watanabe Y, Kasai K, Yamakoshi J, Koga T (2005) Inhibitory effect of an ellagic acid-rich pomegranate extract on tyrosinase activity and ultraviolet-induced pigmentation. Biosci Biotechnol Biochem 69(12):2368–2373
Shimizu K, Kondo R, Sakai K, Takeda N, Nagahata T, Oniki T (2001) Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties. Lipids 36(12):1321–1326
Cho HS, Lee MH, Lee JW et al (2007) Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation. Photodermatol Photoimmunol Photomed 23(5):155–162
Khemis A, Kaiafa A, Queille-Roussel C, Duteil L, Ortonne JP (2007) Evaluation of efficacy and safety of rucinol serum in patients with melasma: a randomized controlled trial. Br J Dermatol 156(5):997–1004
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Tedeschi, A. et al. (2013). Cosmeceuticals in Dermatology. In: Tosti, A., Hexsel, D. (eds) Update in Cosmetic Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34029-1_7
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DOI: https://doi.org/10.1007/978-3-642-34029-1_7
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