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The Use of Nanostructures for DNA Transfection

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NanoCarbon 2011

Part of the book series: Carbon Nanostructures ((CARBON,volume 3))

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Abstract

The interaction between nanostructured materials and living systems is of fundamental and practical interest and will determine the biocompatibility, potential utilities and applications of novel nanomaterials in biological settings. The pursuit of new types of molecular transporters is an active area of research, due to the high impermeability of cell membranes and other biological barriers to foreign substances and the need for intercellular delivery of molecules via cell-penetrating transporter for drug, gene or protein therapeutics. Here, is described the novel nanostructure-based transfection systems. The transfection uses of nanopolymers, nanoparticles and nanotubes are the main focus of this review. In addition are described the technique called NanoSMGT that uses nanostructures for DNA transfection in sperm cells that could be used for transgenic animal generation or human gene therapy.

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Authors and Affiliations

  1. Grupo de Pesquisa em Oncologia Celular e Molecular, Programa de Pós-Graduação em Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas-RS, Brazil

    Vinicius Farias Campos, Virgínia Yurgel, Fabiana Kömmling Seixas & Tiago Collares

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  1. Vinicius Farias Campos
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  2. Virgínia Yurgel
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  3. Fabiana Kömmling Seixas
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  4. Tiago Collares
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Correspondence to Vinicius Farias Campos .

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  1. , Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Rua Félix da Cunha 809, Pelotas, 96010-000, Brazil

    César Avellaneda

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Campos, V.F., Yurgel, V., Seixas, F.K., Collares, T. (2013). The Use of Nanostructures for DNA Transfection. In: Avellaneda, C. (eds) NanoCarbon 2011. Carbon Nanostructures, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31960-0_4

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