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Mechanical and Chemical Signaling in Angiogenesis pp 93–120Cite as

Microfluidic Devices for Angiogenesis

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Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 12))

Abstract

Cell culture has played a central role in developing our understanding of angiogenesis, and a wide variety of culture systems have been adapted for this purpose. Despite the value of this approach, many of the systems employed have suffered from a lack of precise control over culture conditions, an inability to visualize the process of angiogenesis in real time, and limitations in the ability to replicate the in vivo situation in which multiple cell types interact over distances of 100s of microns. With the advent of microfluidics, many of these obstacles can be overcome, and in vitro experiments can be produced with closer relevance to the in vivo situation. In this chapter, we describe the evolution of these microfluidic devices in the context of angiogenesis and describe current capabilities.

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Acknowledgments

The authors would like to acknowledge support from the NIBIB, the National Science Foundation (EFRI-0735997 and CBET-0939511), and the Singapore-MIT Alliance for Research and Technology.

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  1. Mechanical Engineering and Biological Engineering, MIT, Cambridge, MA, USA

    Vernella Vickerman, Choong Kim & Roger D. Kamm

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Correspondence to Roger D. Kamm .

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  1. Department of Biomedical Engineering, Cornell Univesity, Ithaca, USA

    Cynthia A. Reinhart-King

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Vickerman, V., Kim, C., Kamm, R.D. (2013). Microfluidic Devices for Angiogenesis. In: Reinhart-King, C. (eds) Mechanical and Chemical Signaling in Angiogenesis. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30856-7_5

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