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Nanotechnology in Ophthalmic Drug Delivery

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Abstract

Conventional ophthalmic dosage forms are easy to prepare, administer, and their manufacture cost is relatively low. However, aqueous eye solutions suffer from very short contact time with the ocular surface and fast nasolacrimal drainage, both leading to poor bioavailability of the drug. Ointments have visibility and patient acceptably problems whereas suspensions often give rise to unpredictable and variable ocular bioavailability. To address the shortfalls of conventional ophthalmic dosage forms, nanotechnology-based systems have been investigated and some of which have been developed into marketed product. The present chapter overviews the emerging role of nanotechnology in ophthalmic drug delivery with emphasis on what has been patented over the past decade.

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Authors and Affiliations

  1. Faculty of Science, Engineering and Computing, Kingston University London, Kingston upon Thames, London, UK

    Ali A. Al-Kinani, Gianpiero Calabrese, Anil Vangala, Declan Naughton & Raid G. Alany

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  1. Ali A. Al-Kinani
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  2. Gianpiero Calabrese
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Correspondence to Raid G. Alany .

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  1. , Faculty of Health Sciences, University Fernando Pessoa, Rua Carlos da Maia 296, Cacif, Porto, 4200-150, Portugal

    Eliana B. Souto

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Al-Kinani, A.A., Calabrese, G., Vangala, A., Naughton, D., Alany, R.G. (2012). Nanotechnology in Ophthalmic Drug Delivery. In: Souto, E. (eds) Patenting Nanomedicines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29265-1_9

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