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Size-Based Enrichment Technologies for CTC Detection and Characterization

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Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 195))

Abstract

The degree of metastatic outspread in malignant disease is one of the leading factors in determining the appropriate course treatment. Circulating tumor cells (CTCs) represent the population of cells that have acquired the means to gain access to the circulatory system, and the cell population ultimately responsible for the development of metastases at distant sites in the body. While promising as a biomarker for metastatic disease, the widespread study of CTCs has been limited by their rarity, as CTCs are reported to occur as infrequently as 1/mL of whole blood. In this text, we will discuss current and emerging technologies for the size-based enrichment of CTCs from whole blood, and compare some of the advantages and disadvantages of using a size-based approach to CTC enrichment versus affinity-based CTC enrichment platforms.

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Authors and Affiliations

  1. Department of Pathology, University of Miami-Miller School of Medicine, 1501 NW 10th Ave BRB 742, Miami, FL, 33132, USA

    Anthony Williams, Ram Datar & Richard Cote

  2. Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

    Marija Balic

Authors
  1. Anthony Williams
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  2. Marija Balic
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  3. Ram Datar
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  4. Richard Cote
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Corresponding author

Correspondence to Anthony Williams .

Editor information

Editors and Affiliations

  1. , Breast Cancer Translational Res. Lab., Institut Jules Bordet, Boulevard de Waterloo 125, Brussels, 1000, Belgium

    Michail Ignatiadis

  2. , Breast Cancer Translational Res. Lab., Institut Jules Bordet, Boulevard de Waterloo 125, Brussels, 1000, Belgium

    Christos Sotiriou

  3. Zentrum für Experimentelle Medizin, Inst. Tumorbiologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, Hamburg, 20246, Germany

    Klaus Pantel

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© 2012 Springer-Verlag Berlin Heidelberg

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Williams, A., Balic, M., Datar, R., Cote, R. (2012). Size-Based Enrichment Technologies for CTC Detection and Characterization. In: Ignatiadis, M., Sotiriou, C., Pantel, K. (eds) Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer. Recent Results in Cancer Research, vol 195. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28160-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-28160-0_8

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-28159-4

  • Online ISBN: 978-3-642-28160-0

  • eBook Packages: MedicineMedicine (R0)

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