Abstract
Ischemic neuronal injury is characterised by early death mediated by excitotoxicity and by apoptosis. Current evidence indicates that volatile anaesthetic agents, apart from nitrous oxide, barbiturates, and propofol, can protect neurones against ischemic injury caused by excitotoxicity. In the case of volatile agents and propofol, neuroprotection may be sustained if the ischemic insult is relatively mild; however, with moderate to severe insults, this neuronal protection is not sustained after a prolonged recovery period. This suggests that these agents do not protect from delayed neuronal death caused by apoptosis. The long-term effects of any anaesthetic drug on ischemic cerebral injury are not yet defined.
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© 2012 Springer-Verlag Berlin Heidelberg
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Juul, N. (2012). Transportation: Choice of Anaesthetic Drugs. In: Sundstrom, T., Grände, PO., Juul, N., Kock-Jensen, C., Romner, B., Wester, K. (eds) Management of Severe Traumatic Brain Injury. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28126-6_6
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DOI: https://doi.org/10.1007/978-3-642-28126-6_6
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