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Quality control of proteins and organelles by autophagy

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Book cover Protein Quality Control in Neurodegenerative Diseases

Part of the book series: Research and Perspectives in Alzheimer's Disease ((ALZHEIMER))

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Abstract

Macroautophagy is one of the major degradation pathways in the cell. In autophagy, intracellular components are sequestered by autophagosomes and then degraded upon fusion with lysosomes. Genetic analyses of autophagy in mammals have revealed that autophagy is important not only for an adaptive response to starvation but also for quality control of intracellular proteins and organelles. These roles of autophagy are tightly connected to various physiological and pathological processes such as neurodegeneration and tumorigenesis.

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Acknowledgment

This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, the Takeda Science Foundation, and Funding Program for Next Generation World-Leading Researchers.

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  1. Department of Physiology and Cell Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Noboru Mizushima

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Correspondence to Noboru Mizushima .

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  1. Morimoto Lab, Northwestern University, 2205 Tech Drive, Evanston, 60208-3500, Illinois, USA

    Richard I. Morimoto

  2. Fondation IPSEN, Quai Georges Gorse 65, Boulogne-Billancourt Cedex, 92650, France

    Yves Christen

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Mizushima, N. (2013). Quality control of proteins and organelles by autophagy. In: Morimoto, R., Christen, Y. (eds) Protein Quality Control in Neurodegenerative Diseases. Research and Perspectives in Alzheimer's Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27928-7_6

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