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Immunsystem

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Sport und körperliche Aktivität in der Onkologie

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Zusammenfassung

Chronische Inflammationen werden einerseits mitverantwortlich gemacht für die Entstehung von Krebserkrankungen, andererseits kommt es bei diesen in der Regel zu einer inflammatorischen Reaktion, die durch die Therapie noch verstärkt werden kann. Für die Regulation des Immunsystems spielen neben anderen Faktoren, wie z.B. Änderungen der Hormonfreisetzung, pro- und anti-inflammatorische Zytokine eine wesentliche Rolle, da sie an der Regulation der Aktivität des Immunsystems mitwirken. Diese für die Regulation des Immunsystems verantwortlichen Zytokine spielen eine wesentliche Rolle für die inflammatorischen Prozesse bei Krebserkrankungen. Daher werden anti-inflammatorische Therapieansätze zur zusätzlichen Behandlung von Krebserkrankungen getestet, die sich auf die Regulation der Freisetzung von pro- und anti-inflammatorischen Zytokinen beziehen (Aggarwal u. Gehlot 2009). Eine Reihe dieser Zytokine und deren Antagonisten können auch von der Skelettmuskulatur während körperlicher Aktivität gebildet werden, darüber kann die Skelettmuskulatur regulativ auf das Immunsystem einwirken. Es ist daher nicht verwunderlich, dass bei körperlicher Aktivität definierte Veränderungen von pro- und anti-inflammatorischen Faktoren beobachtet werden. Dabei zeigen sich Freisetzungsmuster für die Zytokine, die durchaus gewisse Gemeinsamkeiten mit den Zytokinveränderungen bei entzündlichen Erkrankungen, wie z.B. der Sepsis, aufweisen (Pedersen 2009).

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Authors and Affiliations

  1. II. Medizinische Klinik Hämatologie – Onkologie, Krankenhaus Nordwest, Steinbacher Hohl 2-26, 60488, Frankfurt, Deutschland

    Elke Jäger

  2. Institut für Kreislaufforschung und Sportmedizin Abteilung für molekulare und zelluläre Sportmedizin, Deutsche Sporthochschule Köln, Am Sportpark Müngersdorf 6, 50933, Köln, Deutschland

    Wilhelm Bloch

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  1. Elke Jäger
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© 2012 Springer-Verlag Berlin Heidelberg

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Jäger, E., Bloch, W. (2012). Immunsystem. In: Sport und körperliche Aktivität in der Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25066-8_8

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  • DOI: https://doi.org/10.1007/978-3-642-25066-8_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-25065-1

  • Online ISBN: 978-3-642-25066-8

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