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Interfaces for Analyzing Dose–Response Studies in Microarray Experiments: IsoGeneGUI and ORIOGEN

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Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

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Abstract

In this chapter, we present two interfaces for the analysis of dose–response microarray data. The first, the IsoGeneGUI is a biocunductor menu-based R package. The IsoGeneGUI has the same graphical supports as the IsoGene package, discussed previously in the book, and therefore all the output provided by the IsoGene library can be produced with the IsoGeneGUI as well. The second, the ORIOGEN package (Peddada, Harris, and Harvey 2003) is a java-based interface which can be used to produce the order-restricted analysis presented in Chap. 11.

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References

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Author information

Authors and Affiliations

  1. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    Setia Pramana

  2. Interuniversity Institute for Biostatistics and Statistical Bioinformatics (I-BioStat), Center for Statistics (CenStat), Hasselt University, Diepenbeek, Belgium

    Philippe Haldermans

  3. OpenAnalytics BVBA, Heist-op-den-Berg, Belgium

    Tobias Verbeke

Authors
  1. Setia Pramana
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  2. Philippe Haldermans
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  3. Tobias Verbeke
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Corresponding author

Correspondence to Setia Pramana .

Editor information

Editors and Affiliations

  1. , VMRD, Pfizer Animal Health, Hoge Wei 1, Zaventem, 1930, Belgium

    Dan Lin

  2. Center for Statistics, Hasselt University, Agoralaan 1, Diepenbeek, 3590, Belgium

    Ziv Shkedy

  3. , Department of Statistics and, School of Mathematical Sciences, Ramat Aviv, Tel Aviv, 69978, Israel

    Daniel Yekutieli

  4. Johnson & Johnson, Route 202 1000, Raritan, 08869, New Jersey, USA

    Dhammika Amaratunga

  5. , Biostatistics and Programming Center of, Janssen Pharmaceutica, Turnhoutseweg 30, Beerse, 2340, Belgium

    Luc Bijnens

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Pramana, S., Haldermans, P., Verbeke, T. (2012). Interfaces for Analyzing Dose–Response Studies in Microarray Experiments: IsoGeneGUI and ORIOGEN. In: Lin, D., Shkedy, Z., Yekutieli, D., Amaratunga, D., Bijnens, L. (eds) Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R. Use R!. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24007-2_18

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