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Multi-System Endocrine Disruption pp 145–159Cite as

Adverse Trends of Male Reproductive Health in Two Nordic Countries Indicate Environmental Problems

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Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

Abstract

Current male reproductive health is poor and infertility will be an increasing problem. The reasons are not known, but emerging evidence from experimental animal studies, wildlife, and epidemiological studies combined to our biological and clinical understanding support the hypothesis that environmental endocrine disrupters contribute to the problem. It is therefore important to increase awareness of male reproductive health problems and strengthen interdisciplinary, translational research in this field as specified recently by European Science Foundation (ESF; ESF Science Policy Briefing, September 2010, www.esf.org). Long-term epidemiological studies combining genetic and environmental information with good clinical examinations, biological pathway analyses and effective bioinformatics will be crucial to understand the etiology of poor male reproductive health. Targeted research efforts to better understand mechanisms involved in these processes, including late effects of fetal exposure, will provide paths forward for better male reproductive health.

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References

  • Adami H-O, Bergström R, Möhner M, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo L, Ziegler H, Rahu M, Gurevicius R, Stengrevics A (1994) Testicular cancer in nine Northern European countries. Int J Cancer 59:33–38

    Article  PubMed  CAS  Google Scholar 

  • Aho M, Koivisto AM, Tammela TL, Auvinen A (2000) Is the incidence of hypospadias increasing? Analysis of Finnish hospital discharge data 1970–1994. Environ Health Perspect 108:463–465

    Article  PubMed  CAS  Google Scholar 

  • Auger J, Kunstmann JM, Czyglik F, Jouannet P (1995) Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 332:281–285

    Article  PubMed  CAS  Google Scholar 

  • Bergström R, Adami H-O, Möhner M, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo L, Akre O, Hakulinen T (1996) Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J Natl Cancer Inst 88:727–733

    Article  PubMed  Google Scholar 

  • Boisen KA, Kaleva M, Main KM, Virtanen HE, Haavisto A-M, Schmidt IM, Chellakooty M, Damgaard IN, Mau C, Reunanen M, Skakkebæk NE, Toppari J (2004) Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries. Lancet 363:1264–1269

    Article  PubMed  CAS  Google Scholar 

  • Boisen KA, Chellakooty M, Schmidt IM, Kai CM, Damgaard IN, Suomi AM, Toppari J, Skakkebæk NE, Main KM (2005) Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at 3 months of age. J Clin Endocrinol Metab 90:4041–4046

    Article  PubMed  CAS  Google Scholar 

  • Bray F, Ferlay J, Devesa SS, McGlynn KA, Møller H (2006a) Interpreting the international trends in testicular seminoma and nonseminoma incidence. Natl Clin Pract Urol 3:532–543

    Article  Google Scholar 

  • Bray F, Richiardi L, Ekbom A, Pukkala E, Cuninkova M, Moller H (2006b) Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality. Int J Cancer 118:3099–3111

    Article  PubMed  CAS  Google Scholar 

  • Carlsen E, Giwercman A, Keiding N, Skakkebæk NE (1992) Evidence for decreasing quality of semen during past 50 years. BMJ 305:609–613

    Article  PubMed  CAS  Google Scholar 

  • Carlsen E, Swan SH, Holm PJ, Skakkebæk NE (2005) Longitudinal changes in semen parameters in young Danish men from the Copenhagen area. Hum Reprod 20:942–949

    Article  PubMed  Google Scholar 

  • Christiansen S, Scholze M, Axelstad M, Boberg J, Kortenkamp A, Hass U (2008) Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat. Int J Androl 31:241–248

    Article  PubMed  CAS  Google Scholar 

  • Damgaard IN, Skakkebæk NE, Toppari J, Virtanen HE, Shen H, Schramm KW, Petersen JH, Jensen TK, The Nordic Cryptorchidism Study Group, Main KM (2006) Persistent pesticides in human breast milk and cryptorchidism. Environ Health Perspect 114:1133–1138

    Article  PubMed  CAS  Google Scholar 

  • Fisher JS, Macpherson S, Marchetti N, Sharpe RM (2003) Human “testicular dysgenesis syndrome”: a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod 18:1383–1394

    Article  PubMed  CAS  Google Scholar 

  • Foster PM (2006) Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl 29:140–147

    Article  PubMed  CAS  Google Scholar 

  • Goriely A, Hansen RM, Taylor IB, Olesen IA, Jacobsen GK, McGowan SJ, Pfeifer SP, McVean GA, Rajpert-De Meyts E, Wilkie AO (2009) Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. Nat Genet 41:1247–1252

    Article  PubMed  CAS  Google Scholar 

  • Hadziselimovic F, Hocht B, Herzog B, Buser MW (2007) Infertility in cryptorchidism is linked to the stage of germ cell development at orchidopexy. Horm Res 68:46–52

    Article  PubMed  CAS  Google Scholar 

  • Hardell L, van Bavel B, Lindstrom G, Carlberg M, Dreifaldt AC, Wijkstrom H, Starkhammar H, Eriksson M, Hallquist A, Kolmert T (2003) Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer. Environ Health Perspect 111:930–934

    Article  PubMed  CAS  Google Scholar 

  • Hardell L, van Bavel B, Lindstrom G, Eriksson M, Carlberg M (2006) In utero exposure to persistent organic pollutants in relation to testicular cancer risk. Int J Androl 29:228–234

    Article  PubMed  CAS  Google Scholar 

  • Hass U, Scholze M, Christiansen S, Dalgaard M, Vinggaard AM, Axelstad M, Metzdorff SB, Kortenkamp A (2007) Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat. Environ Health Perspect 115(Suppl 1):122–128

    Article  PubMed  Google Scholar 

  • Irvine S, Cawood E, Richardson D, MacDonald E, Aitken J (1996) Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years. Br Med J 312:467–471

    CAS  Google Scholar 

  • Iwamoto T, Hoshino T, Nishida T, Baaba K, Matsusita T, Kaneko S, Tanaka N, Naka M, Yoshiike M, Nozawa S, Skakkebæk NE, Jørgensen N (2006) Semen quality of 324 fertile Japanese men. Hum Reprod 21:760–765

    Article  PubMed  CAS  Google Scholar 

  • Jensen TK, Vierula M, Hjollund NHI, Saaranen M, Scheike T, Saarikoski S, Suominen J, Keiski A, Toppari J, Skakkebæk NE, The Danish First Pregnancy Planner Study Team (2000) Semen quality among Danish and Finnish men attempting to conceive. Eur J Endocrinol 142:47–52

    Article  PubMed  CAS  Google Scholar 

  • Jensen TK, Andersson A-M, Jørgensen N, Andersen A-G, Carlsen E, Petersen JH, Skakkebæk NE (2004a) Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 82:863–870

    Article  PubMed  CAS  Google Scholar 

  • Jensen TK, Jørgensen N, Punab M, Haugen TB, Suominen J, Zilaitiene B, Horte A, Andersen A-G, Carlsen E, Magnus Ø, Matulevicius V, Nermoen I, Vierula M, Keiding N, Toppari J, Skakkebæk NE (2004b) Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries. Am J Epidemiol 159:49–58

    Article  PubMed  Google Scholar 

  • Jensen MS, Mabeck LM, Toft G, Thulstrup AM, Bonde JP (2005) Lower sperm counts following prenatal tobacco exposure. Hum Reprod 20:2559–2566

    Article  PubMed  CAS  Google Scholar 

  • Jensen MS, Toft G, Thulstrup AM, Henriksen TB, Olsen J, Christensen K, Bonde JP (2010) Cryptorchidism concordance in monozygotic and dizygotic twin brothers, full brothers, and half-brothers. Fertil Steril 93:124–129

    Article  PubMed  Google Scholar 

  • Johnson L, Zane RS, Petty CS, Neaves WB (1984) Quantification of the human Sertoli cell population: its distribution, relation to germ cell numbers, and age-related decline. Biol Reprod 31:785–795

    Article  PubMed  CAS  Google Scholar 

  • Jørgensen N, Andersen A-G, Eustache F, Irvine DS, Suominen J, Petersen JH, Andersen AN, Auger J, Cawood EHH, Horte A, Jensen TK, Jouannet P, Keiding N, Vierula M, Toppari J, Skakkebæk NE (2001) Regional differences in semen quality in Europe. Hum Reprod 16:1012–1019

    Article  PubMed  Google Scholar 

  • Jørgensen N, Carlsen E, Nermoen I, Punab M, Suominen J, Andersen A-G, Andersson A-M, Haugen TB, Horte A, Jensen TK, Magnus Ø, Petersen JH, Vierula M, Toppari J, Skakkebæk NE (2002) East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. Hum Reprod 17:2199–2208

    Article  PubMed  Google Scholar 

  • Jørgensen N, Asklund C, Carlsen E, Skakkebæk NE (2006) Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern. Int J Androl 29:54–61

    Article  PubMed  Google Scholar 

  • Jørgensen N, Vierula M, Jacobsen R, Pukkala E, Perheentupa A, Virtanen HE, Skakkebæk NE, Toppari J (2011) Recent adverse trends in semen quality and testis cancer incidence among Finnish men. Int J Androl 34:e37–e48. doi:10.1111/j.1365-2605.2010.01133.x

    Google Scholar 

  • Kanetsky PA, Mitra N, Vardhanabhuti S, Li M, Vaughn DJ, Letrero R, Ciosek SL, Doody DR, Smith LM, Weaver J, Albano A, Chen C, Starr JR, Rader DJ, Godwin AK, Reilly MP, Hakonarson H, Schwartz SM, Nathanson KL (2009) Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet 41:811–815

    Article  PubMed  CAS  Google Scholar 

  • Kollin C, Karpe B, Hesser U, Granholm T, Ritzen EM (2007) Surgical treatment of unilaterally undescended testes: testicular growth after randomization to orchiopexy at age 9 months or 3 years. J Urol 178:1589–1593

    Article  PubMed  Google Scholar 

  • Krysiak-Baltyn K, Toppari J, Skakkebæk NE, Jensen TS, Virtanen HE, Schramm KW, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Brunak S, Main KM (2010) Country-specific chemical signatures of persistent environmental compounds in breast milk. Int J Androl 33:270–278

    Article  PubMed  CAS  Google Scholar 

  • Lee PA (1993) Fertility in chryptorchidism. Endocrinol Metab Clin North Am 33(3):479–490

    Google Scholar 

  • Lee PA (2005) Fertility after cryptorchidism: epidemiology and other outcome studies. Urology 66:427–431

    Article  PubMed  Google Scholar 

  • Llanes GL, Lujan GM, Rodriguez GN, Garcia TA, Berenguer SA (2008) Trends in the incidence of testicular germ cell cancer in a 300.000 inhabitants Spanish population (1991–2005). Actas Urol Esp 32:691–695

    Google Scholar 

  • Lund L, Engebjerg MC, Pedersen L, Ehrenstein V, Norgaard M, Sorensen HT (2009) Prevalence of hypospadias in Danish boys: a longitudinal study, 1977–2005. Eur Urol 55:1022–2026

    Article  PubMed  Google Scholar 

  • Main KM, Mortensen GK, Kaleva M, Boisen K, Damgaard I, Chellakooty M, Schmidt IM, Suomi A-M, Virtanen H, Petersen JH, Andersson A-M, Toppari J, Skakkebæk NE (2006) Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in three months old infants. Environ Health Perspect 114:270–276

    Article  PubMed  CAS  Google Scholar 

  • Main KM, Kiviranta H, Virtanen HE, Sundqvist E, Tuomisto JT, Tuomisto J, Vartiainen T, Skakkebæk NE, Toppari J (2007) Flame retardants in placenta and breast milk and cryptorchidism in Newborn boys. Environ Health Perspect 115:1519–1526

    PubMed  CAS  Google Scholar 

  • Mocarelli P, Gerthoux PM, Needham LL, Patterson DG Jr, Limonta G, Falbo R, Signorini S, Bertona M, Crespi C, Sarto C, Scott PK, Turner WE, Brambilla P (2010) Perinatal exposure to low doses of dioxin can permanently impair human semen quality. Environ Health Perspect. doi:10.1289/ehp. 1002134

  • Myrup C, Schnack TH, Wohlfahrt J (2007) Correction of cryptorchidism and testicular cancer. N Engl J Med 357:825–827

    Article  PubMed  CAS  Google Scholar 

  • Olsen GW, Bodner KM, Ramlow JM, Ross CE, Lipshultz LI (1995) Have sperm counts been reduced 50 percent in 50 years? A statistical model revisited. Fertil Steril 63:887–893

    PubMed  CAS  Google Scholar 

  • Paasch U, Salzbrunn A, Glander HJ, Salzbrunn H, Grunewald S, Stucke J, Skakkebæk NE, Jørgensen N (2008) Semen quality in sub-fertile range for a significant proportion of young men from the general German population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig. Int J Androl 31:93–102

    Article  PubMed  Google Scholar 

  • Pajarinen J, Laippala P, Penttila A, Karhunen PJ (1997) Incidence of disorders of spermatogenesis in middle aged Finnish men, 1981–91: two necropsy series. Br Med J 314:13–18

    CAS  Google Scholar 

  • Pierik FH, Burdorf A, Nijman JM, de Muinck Keizer-Schrama SM, Juttmann RE, Weber RF (2002) A high hypospadias rate in the Netherlands. Hum Reprod 17:1112–1115

    Article  PubMed  Google Scholar 

  • Quigley CA, DeBellis A, Marschke KB, El-Awady MK, Wilson EM, French FS (1995) Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr Rev 16:271–321

    PubMed  CAS  Google Scholar 

  • Rajpert-De Meyts E (2006) Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects. Hum Reprod Update 12:303–323

    Google Scholar 

  • Rapley EA, Turnbull C, Al Olama AA, Dermitzakis ET, Linger R, Huddart RA, Renwick A, Hughes D, Hines S, Seal S, Morrison J, Nsengimana J, Deloukas P, Rahman N, Bishop DT, Easton DF, Stratton MR (2009) A genome-wide association study of testicular germ cell tumor. Nat Genet 41:807–810

    Article  PubMed  CAS  Google Scholar 

  • Ravnborg TL, Jensen TK, Andersson AM, Toppari J, Skakkebaek NE, Jorgensen N (2011) Prenatal and adult exposures to smoking are associated with adverse effects on reproductive hormones, semen quality, final height and body mass index. Hum Reprod. doi:10.1093/humrep/der011

    Google Scholar 

  • Rey RA, Codner E, Iniguez G, Bedecarras P, Trigo R, Okuma C, Gottlieb S, Bergada I, Campo SM, Cassorla FG (2005) Low risk of impaired testicular sertoli and leydig cell functions in boys with isolated hypospadias. J Clin Endocrinol Metab 90:6035–6040

    Article  PubMed  CAS  Google Scholar 

  • Rider CV, Furr J, Wilson VS, Gray LE Jr (2008) A mixture of seven antiandrogens induces reproductive malformations in rats. Int J Androl 31:249–262

    Article  PubMed  CAS  Google Scholar 

  • Rider CV, Wilson VS, Howdeshell KL, Hotchkiss AK, Furr JR, Lambright CR, Gray LE Jr (2009) Cumulative effects of in utero administration of mixtures of antiandrogens on male rat reproductive development. Toxicol Pathol 37:100–113

    Article  PubMed  CAS  Google Scholar 

  • Schnack TH, Zdravkovic S, Myrup C, Westergaard T, Wohlfahrt J, Melbye M (2008) Familial aggregation of cryptorchidism–a nationwide cohort study. Am J Epidemiol 167:1453–1457

    Article  PubMed  Google Scholar 

  • Schnack TH, Poulsen G, Myrup C, Wohlfahrt J, Melbye M (2010) Familial coaggregation of cryptorchidism, hypospadias, and testicular germ cell cancer: a nationwide cohort study. J Natl Cancer Inst 102:187–192

    Google Scholar 

  • Skakkebæk NE, Rajpert-De Meyts E, Main KM (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16:972–978

    Article  PubMed  Google Scholar 

  • Skakkebæk NE, Jørgensen N, Main KM, Rajpert-De Meyts E, Leffers H, Andersson A-M, Juul A, Carlsen E, Mortensen GK, Jensen TK, Toppari J (2006) Is human fecundity declining? Int J Androl 29:2–11

    Article  PubMed  Google Scholar 

  • Suomi A-M, Main KM, Kaleva M, Schmidt IM, Chellakooty M, Virtanen HE, Boisen KA, Damgaard IN, Kai CM, Skakkebæk NE, Toppari J (2006) Hormonal changes in 3-month-old cryptorchid boys. J Clin Endocrinol Metab 91:953–958

    Article  PubMed  CAS  Google Scholar 

  • Suominen J, Vierula M (1993) Semen quality of Finnish men. Br Med J 306:1579

    Article  CAS  Google Scholar 

  • Swan SH, Elkin EP, Fenster L (1997) Have sperm densities declined? A reanalysis of global trend data. Environ Health Perspect 105:1228–1232

    Article  PubMed  CAS  Google Scholar 

  • Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S, Teague JL (2005) Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect 113:1056–1061

    Article  PubMed  CAS  Google Scholar 

  • Taskinen S, Hovatta O, Wikstrom S (1997) Sexual development in patients treated for cryptorchidism. Scand J Urol Nephrol 31:361–364

    Article  PubMed  CAS  Google Scholar 

  • Toppari J, Kaleva M, Virtanen HE (2001) Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data. Hum Reprod Update 7:282–286

    Article  PubMed  CAS  Google Scholar 

  • van der Zanden LF, van Rooij I, Feitz WF, Knight J, Donders AR, Renkema KY, Bongers EM, Vermeulen SH, Kiemeney LA, Veltman JA, Arias-Vasquez A, Zhang X, Markljung E, Qiao L, Baskin LS, Nordenskjold A, Roeleveld N, Franke B, Knoers NV (2011a) Corrigendum: common variants in DGKK are strongly associated with risk of hypospadias. Nat Genet 43:277

    Article  Google Scholar 

  • van der Zanden LF, van Rooij I, Feitz WF, Knight J, Donders AR, Renkema KY, Bongers EM, Vermeulen SH, Kiemeney LA, Veltman JA, Arias-Vasquez A, Zhang X, Markljung E, Qiao L, Baskin LS, Nordenskjold A, Roeleveld N, Franke B, Knoers NV (2011b) Common variants in DGKK are strongly associated with risk of hypospadias. Nat Genet 43:48–50

    Article  PubMed  Google Scholar 

  • Vierula M, Niemi M, Keiski A, Saaranen M, Saarikoski S, Suominen J (1996) High and unchanged sperm counts of Finnish men. Int J Androl 19:11–17

    Article  PubMed  CAS  Google Scholar 

  • Virtanen HE, Kaleva M, Haavisto A-M, Schmidt IM, Chellakooty M, Main KM, Skakkebæk NE, Toppari J (2001) The birth rate of hypospadias in the Turku area in Finland. APMIS 109:96–100

    Article  PubMed  CAS  Google Scholar 

  • Whorton D, Krauss RM, Marshall S, Milby TH (1977) Infertility in male pesticide workers. Lancet 2:1259–1261

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

We thank Dr. Niels Jørgensen for making Fig. 1 available to us. The studies were supported by the Academy of Finland, the Sigrid Jusélius Foundation, EU the European Commission (QLK4-CT-1999-01422, QLK4-CT-2001-8 00269, QLK4-2002-00603, FP7/2008-2012: DEER 212844), the Danish Medical Research Council (9700833, 9700909), the Svend Andersen’s, Velux and Novo Nordisk Foundations, and the Danish Network on Endocrine Disrupters (DAN-ED).

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Authors and Affiliations

  1. Departments of Physiology and Paediatrics, University of Turku, Turku, Finland

    Jorma Toppari

  2. University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark

    Niels E. Skakkebaek

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  1. Jorma Toppari
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  2. Niels E. Skakkebaek
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Correspondence to Jorma Toppari .

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Editors and Affiliations

  1. , Developmental Neuroendocrinology Unit, G, University of Liège, Place du XX Aout 7, Liège, Belgium

    Jean-Pierre Bourguignon

  2. Campus de Beaulieu, GERHM Inserm U625, Avenue du Général Leclerc, Rennes, 35042, France

    Bernard Jégou

  3. Inserm U648, UFR Biomédicale, Centre Universitaire des Saints-Pères, Paris Cedex 06, 75270, France

    Bernard Kerdelhué

  4. , Departments of Physiology and, University of Turku, Kiinamyllynkatu 10, Turku, 20520, Finland

    Jorma Toppari

  5. Fondation Ipsen, Quai Georges Gorse 65, Boulogne-Billancourt, 92100, France

    Yves Christen

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Toppari, J., Skakkebaek, N.E. (2011). Adverse Trends of Male Reproductive Health in Two Nordic Countries Indicate Environmental Problems. In: Bourguignon, JP., Jégou, B., Kerdelhué, B., Toppari, J., Christen, Y. (eds) Multi-System Endocrine Disruption. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22775-2_10

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