Skip to main content
SpringerLink
Log in
Book cover

Selenoproteins and Mimics pp 77–88Cite as

Selenoprotein P

  • Chapter

Part of the book series: Advanced Topics in Science and Technology in China ((ATSTC))

Abstract

Selenoprotein P (SeP) is a selenium-rich extracellular glycoprotein and is the major selenoprotein in plasma. SeP is presumed to be composed of two domains: one possesses redox-enzyme activity containing one selenocysteine residue in the N-terminal region, and the other functions as a selenium supplier containing nine selenocysteine residues in the C-terminal region. These domains are connected by a bridge containing two histidine-rich regions. Although the relationship between structure and function is not clear, SeP is reported to function as a peroxynitrite scavenger, or cell survival factor in the primary culture of neurons. Thus, SeP is a multifunctional protein. Increasing evidence indicates that SeP plays a significant role in vivo in the maintenance of selenium levels in the brain and testis. In the present review, we describe the structural properties and molecular function of SeP and discuss its significant role in cellular homeostasis, particularly in relation to selenium levels and the antioxidative system.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hatfield DL, Berry MJ, Gladyshev VN (2006) Selenium: Its Molecular Biology and Role in Human Health. Springer-Verlag, New York

    Google Scholar 

  2. Squires JE, Berry MJ (2008) IUBMB life 60: 232

    Article  PubMed  CAS  Google Scholar 

  3. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R, Gladyshev VN (2003) Science 300: 1439

    Article  PubMed  CAS  Google Scholar 

  4. Motsenbocker MA, Tappel AL (1982) Biochimica et Biophysica Acta 719: 147

    Article  PubMed  CAS  Google Scholar 

  5. Burk RF (1973) Proc Soc Exp Biol Med 143: 719

    PubMed  CAS  Google Scholar 

  6. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Science 179: 588

    Article  PubMed  CAS  Google Scholar 

  7. Burk RF, Hill KE (2005) Ann Rev Nutr 25: 215

    Article  CAS  Google Scholar 

  8. Burk RF, Hill KE (2009) Biochim Biophys Acta 1790: 1441

    Article  PubMed  CAS  Google Scholar 

  9. Hill KE, Lloyd RS, Burk RF (1993) Proc Nat Acad Sci USA 90: 537

    Article  PubMed  CAS  Google Scholar 

  10. Saito Y, Takahashi K (2000) J Health Sci 46: 409

    Article  CAS  Google Scholar 

  11. Lu J, Holmgren A (2009) J Biol Chem 284: 723

    Article  PubMed  CAS  Google Scholar 

  12. Deagen JT, Butler JA, Zachara BA, Whanger PD (1993) Anal Biochem 208: 176

    Article  PubMed  CAS  Google Scholar 

  13. Burk RF, Hill KE, Boeglin ME, Ebner FF, Chittum HS (1997) Histochem Cell Biol 108: 11

    Article  PubMed  CAS  Google Scholar 

  14. Hondal RJ, Ma S, Caprioli RM, Hill KE, Burk RF (2001) J Biol Chem 276: 15823

    Article  PubMed  CAS  Google Scholar 

  15. Karlsson K, Lindahl U, Marklund SL (1988) Biochem J 256: 29

    PubMed  CAS  Google Scholar 

  16. Karlsson K, Marklund SL (1988) Biochem J 255: 223

    PubMed  CAS  Google Scholar 

  17. Hamer DH (1986) Ann Rev Biochem 55: 913

    Article  PubMed  CAS  Google Scholar 

  18. Saito Y, Hayashi T, Tanaka A, Watanabe Y, Suzuki M, Saito E, Takahashi K (1999) J Biol Chem 274: 2866

    Article  PubMed  CAS  Google Scholar 

  19. Suzuki KT, Sasakura C, Yoneda S (1998) Biochim Biophys Acta 1429: 102

    Article  PubMed  CAS  Google Scholar 

  20. Yoneda S, Suzuki KT (1997) Toxicol Appl Pharmacol 143: 274

    Article  PubMed  CAS  Google Scholar 

  21. Kaneko JJ, Ralston NV (2007) Biol Trace Elem Res 119: 242

    Article  PubMed  CAS  Google Scholar 

  22. Himeno S, Chittum HS, Burk RF (1996) J Biol Chem 271: 15769

    Article  PubMed  CAS  Google Scholar 

  23. Ma S, Capriolia RM, Hill KE, Burk RF (2003) J Am Soc Mass Spectrom 14: 593

    Article  PubMed  CAS  Google Scholar 

  24. Akesson B, Bellew T, Burk RF (1994) Biochim Biophys Acta 1204: 243

    Article  PubMed  CAS  Google Scholar 

  25. Yang JG, Morrison-Plummer J, Burk RF (1987) J BiolChem 262: 13372

    CAS  Google Scholar 

  26. Saito Y, Sato N, Hirashima M, Takebe G, Nagasawa S, Takahashi K (2004) Biochem J 381: 841

    Article  PubMed  CAS  Google Scholar 

  27. Kato H, Nagasawa S, Iwanaga S (1981) Methods Enzymol 80: 172

    Article  PubMed  CAS  Google Scholar 

  28. Cochrane CG, Revak SD, Wuepper KD (1973) J Exp Med 138: 1564

    Article  PubMed  CAS  Google Scholar 

  29. Mandle RJ, Kaplan AP (1977) J Biol Chem 252: 6097

    PubMed  CAS  Google Scholar 

  30. Ma S, Hill KE, Caprioli RM, Burk RF (2002) J Biol Chem 277: 12749

    Article  PubMed  CAS  Google Scholar 

  31. Kryukov GV, Gladyshev VN (2000) Genes Cells 5: 1049

    Article  PubMed  CAS  Google Scholar 

  32. Takebe G, Yarimizu J, Saito Y, Hayashi T, Nakamura H, Yodoi J, Nagasawa S, Takahashi K (2002) J Biol Chem 277: 41254

    Article  PubMed  CAS  Google Scholar 

  33. Saito Y, Takahashi K (2002) Eur J Biochem/FEBS 269: 5746

    Article  CAS  Google Scholar 

  34. Sies H, Arteel GE (2000) Free Rad Biol Med 28: 1451

    Article  PubMed  CAS  Google Scholar 

  35. Yamamoto Y, Takahashi K (1993) Arch Biochem Biophys 305: 541

    Article  PubMed  CAS  Google Scholar 

  36. Kernstock RM, Girotti AW (2008) Prot Exp Purificat 62: 216

    Article  CAS  Google Scholar 

  37. Saito Y, Yoshida Y, Akazawa T, Takahashi K, Niki E (2003) J Biol Chem 278: 39428

    Article  PubMed  CAS  Google Scholar 

  38. Saito Y, Yoshida Y, Niki E (2007) FEBS lett 581: 4349

    Article  PubMed  CAS  Google Scholar 

  39. Ursini F, Maiorino M, Gregolin C (1985) Biochim Biophys Acta 839: 62

    Article  PubMed  CAS  Google Scholar 

  40. Masutani H, Yodoi J (2002) Methods Enzymol 347: 279

    Article  PubMed  CAS  Google Scholar 

  41. Wakasugi N, Tagaya Y, Wakasugi H, Mitsui A, Maeda M, Yodoi J, Tursz T (1990) Proc Nat Acad Sci USA 87: 8282

    Article  PubMed  CAS  Google Scholar 

  42. Soderberg A, Sahaf B, Rosen A (2000) Cancer Res 60: 2281

    PubMed  CAS  Google Scholar 

  43. McKeehan WL, Hamilton WG, Ham RG (1976) Proc Nat Acad Sci USA 73: 2023

    Article  PubMed  CAS  Google Scholar 

  44. Thomas JP, Maiorino M, Ursini F, Girotti AW (1990) J Biol Chem 265: 454

    PubMed  CAS  Google Scholar 

  45. Yan J, Barrett JN (1998) J Neurosci 18: 8682

    PubMed  CAS  Google Scholar 

  46. Steinbrenner H, Bilgic E, Alili L, Sies H, Brenneisen P (2006) Free Rad Res 40: 936

    Article  CAS  Google Scholar 

  47. Bosschaerts T, Guilliams M, Noel W, Herin M, Burk RF, Hill KE, Brys L, Raes G, Ghassabeh GH, De Baetselier P, Beschin A (2008) J Immunol 180: 6168

    PubMed  CAS  Google Scholar 

  48. Valentine WM, Abel TW, Hill KE, Austin LM, Burk RF (2008) J Neuropath Exp Neurol 67: 68

    Article  PubMed  Google Scholar 

  49. Yoshida Y, Itoh N, Hayakawa M, Habuchi Y, Saito Y, Tsukamoto Y, Cynshi O, Jishage KI, Arai H, Niki E (2010) J Nutr Biochem 21: 66

    Article  PubMed  CAS  Google Scholar 

  50. Schweizer U, Streckfuss F, Pelt P, Carlson BA, Hatfield DL, Kohrle J, Schomburg L (2005) Biochem J 386: 221

    Article  PubMed  CAS  Google Scholar 

  51. Scharpf M, Schweizer U, Arzberger T, Roggendorf W, Schomburg L, Kohrle J (2007) J Neural Transm 114: 877

    Article  PubMed  CAS  Google Scholar 

  52. Bellinger FP, He QP, Bellinger MT, Lin Y, Raman AV, White LR, Berry MJ (2008) J Alzheimers Dis 15: 465

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Life Systems, Faculty of Medical and Life Sciences, Doshisha University, Kyotanabe, Kyoto, Japan

    Yoshiro Saito

  2. Department of Nutritional Biochemistry, Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Hokkaido, Japan

    Kazuhiko Takahashi

Authors
  1. Yoshiro Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazuhiko Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Zhejiang University Press, Hangzhou and Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Saito, Y., Takahashi, K. (2011). Selenoprotein P. In: Selenoproteins and Mimics. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22236-8_5

Download citation

Publish with us

Policies and ethics

Search

Navigation