Abstract
Selenium is an essential trace element for humans and animals. It plays a putative role in the prevention of cancer and some other diseases. GPx generally catalyze the reduction of peroxides mainly using glutathione as the electron donor, thus contributing to the body’s defence against free radicals. In the above chapters, we described some GPx mimics that were synthesized in different ways. These GPx mimics possess their own advantages and disadvantages respectively. However, some of them display remarkable antioxidant ability which indicates that they are promising candidates for medicinal applications. In this chapter, we will mainly describe the biological effect of these GPx mimics in different levels (organelles, cells and animals) and in different model systems.
Keywords
- Inhibit Lipid Peroxidation
- Antioxidant Ability
- Dehydroascorbic Acid
- TBARS Content
- Electronic Spin Resonance
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2011 Zhejiang University Press, Hangzhou and Springer-Verlag Berlin Heidelberg
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Yan, F., Mu, Y. (2011). Selenoprotein Mimics and Diseases. In: Selenoproteins and Mimics. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22236-8_20
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DOI: https://doi.org/10.1007/978-3-642-22236-8_20
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