Abstract
Melanocytic lesion exploration is conducted by the examination of mosaics and/or series of consecutive high-resolution images from the surface to the dermis up to the loss of resolution (approximately up to 200 μm). Mosaics are usually acquired at three levels (superficial layers, dermal-epidermal junction, upper dermis) for the evaluation of general epidermal pattern, frequencies and distribution of pagetoid cells, regularity of the DEJ architecture, presence and distribution of nests, and structures within the papillary dermis. High-resolution images are employed for the evaluation of cyto-architectural aspects.
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References
Busam KJ, Charles C, Lee G, Halpern AC (2001) Morphological features of melanocytes, pigmented keratinocytes, and melanophages by in vivo confocal scanning laser microscopy. Mod Pathol 14:862–868
Langley RGB, Rajadhyaksha M, Dweyer PJ, Sober AJ, Flotte TJ, Andersson RR (2001) Confocal scanning laser microscopy of benign and malignant melanocytic skin lesions in vivo. J Am Acad Dermatol 45:365–376
Pellacani G, Cesinaro AM, Seidenari S (2005) Reflectance-mode confocal microscopy for the in vivo characterization of pagetoid melanocytosis in melanomas and nevi. J Invest Dermatol 125:532–537
Pellacani G, Cesinaro AM, Longo C, Grana C, Seidenari S (2005) Microscopic in vivo description of cellular architecture of dermoscopic pigment network in nevi and melanomas. Arch Dermatol 141:147–154
Pellacani G, Cesinaro AM, Seidenari S (2005) In vivo assessment of melanocytic nests in nevi and melanomas by reflectance confocal microscopy. Mod Pathol 18:469–474
Pellacani G, Cesinaro AM, Seidenari S (2005) Reflectance-mode confocal microscopy of pigmented skin lesions–improvement in melanoma diagnostic specificity. J Am Acad Dermatol 53:979–985
Pellacani G, Scope A, Ferrari B, Pupelli G, Bassoli S, Longo C, Cesinaro AM, Argenziano G, Hofmann-Wellenhof R, Malvehy J, Marghoob AA, Puig S, Seidenari S, Soyer HP, Zalaudek I (2009) New insights into nevogenesis: in vivo characterization and follow-up of melanocytic nevi by reflectance confocal microscopy. J Am Acad Dermatol 61:1001–1013
Scope A, Benvenuto-Andrade C, Agero AL, Malvehy J, Puig S, Rajadhyaksha M et al (2007) In vivo reflectance confocal microscopy imaging of melanocytic skin lesions: consensus terminology glossary and illustrative images. J Am Acad Dermatol 57:644–658
Pellacani G, Vinceti M, Bassoli S, Braun R, Gonzalez S, Guitera P, Longo C, Marghoob AA, Menzies SW, Puig S, Scope A, Seidenari S, Malvehy J (2009) Reflectance confocal microscopy and features of melanocytic lesions: an internet-based study of the reproducibility of terminology. Arch Dermatol 145(10):1137–1143
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Ferrari, B., Soyer, H.P., Casari, A., Pellacani, G. (2012). Semeiology and Pattern Analysis in Melanocytic Lesions. In: Hofmann-Wellenhof, R., Pellacani, G., Malvehy, J., Soyer, H. (eds) Reflectance Confocal Microscopy for Skin Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21997-9_6
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DOI: https://doi.org/10.1007/978-3-642-21997-9_6
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