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Oral Microbes in Health and Disease

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Beneficial Microorganisms in Multicellular Life Forms

Abstract

Oral bacteria were the first bacteria reported over 300 years ago, yet oral microbiology is still a developing field. Recent advances in molecular biology greatly improve our understanding of the oral microbiota. Oral bacteria form multispecies biofilms on oral surfaces in order to resist salivary wash and mechanical cleaning. These multispecies environments dictate oral health or disease. More than 700 oral bacterial species have been identified so far. Current technology enables for the first time the definition of the microbial composition associated with oral health and disease. Understanding the changes occurring in the microbial composition during transition from oral health to disease should lead to novel approaches to prevent and to treat oral disease.

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References

  • Aas JA, Griffen AL, Dardis SR, Lee AM, Olsen I, Dewhirst FE, Leys EJ, Paster BJ (2008) Bacteria of dental caries in primary and permanent teeth in children and young adults. J Clin Microbiol 46:1407–1417

    Article  PubMed  CAS  Google Scholar 

  • Arends J, Christoffersen J (1986) The nature of early caries lesions in enamel. J Dent Res 65:2–11

    Article  PubMed  CAS  Google Scholar 

  • Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4:1–6

    Article  PubMed  CAS  Google Scholar 

  • Axelsson P, Nystrom B, Lindhe J (2004) The long-term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults. Results after 30 years of maintenance. J Clin Periodontol 31:749–757

    Article  PubMed  CAS  Google Scholar 

  • Baker PJ (2000) The role of immune responses in bone loss during periodontal disease. Microbes Infect 2:1181–1192

    Article  PubMed  CAS  Google Scholar 

  • Bos R, van der Mei HC, Busscher HJ (1996) Co-adhesion of oral microbial pairs under flow in the presence of saliva and lactose. J Dent Res 75:809–815

    Article  PubMed  CAS  Google Scholar 

  • Brotherton P, Endicott P, Sanchez JJ, Beaumont M, Barnett R, Austin J, Cooper A (2007) Novel high-resolution characterization of ancient DNA reveals C > U-type base modification events as the sole cause of post mortem miscoding lesions. Nucleic Acids Res 35:5717–5728

    Article  PubMed  CAS  Google Scholar 

  • Cobb CM, Costerton JW, Van Dyke TE (2009) Have we become so focused on inflammation and host response that we have neglected the role of bacteria in initiating periodontal disease? Compend Contin Educ Dent 30(46):48

    Google Scholar 

  • Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner AC, Yu WH, Lakshmanan A, Wade WG (2010) The human oral microbiome. J Bacteriol 192:5002–5017

    Article  PubMed  CAS  Google Scholar 

  • Dixon DR, Bainbridge BW, Darveau RP (2004) Modulation of the innate immune response within the periodontium. Periodontol 2000 35:53–74

    Article  PubMed  Google Scholar 

  • Egland PG, Palmer RJ Jr, Kolenbrander PE (2004) Interspecies communication in Streptococcus gordonii-Veillonella atypica biofilms: signaling in flow conditions requires juxtaposition. Proc Natl Acad Sci USA 101:16917–16922

    Article  PubMed  CAS  Google Scholar 

  • Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, Offenbacher S, Ridker PM, Van Dyke TE, Roberts WC (2009) The American Journal of Cardiology and Journal of Periodontology editors’ consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 80:1021–1032

    Article  PubMed  Google Scholar 

  • Gibson FC 3rd, Genco CA (2007) Porphyromonas gingivalis mediated periodontal disease and atherosclerosis: disparate diseases with commonalities in pathogenesis through TLRs. Curr Pharm Des 13:3665–3675

    Article  PubMed  CAS  Google Scholar 

  • Gronert K, Kantarci A, Levy BD, Clish CB, Odparlik S, Hasturk H, Badwey JA, Colgan SP, Van Dyke TE, Serhan CN (2004) A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage. J Immunol 172:1856–1861

    PubMed  CAS  Google Scholar 

  • Grossi SG, Genco RJ (1998) Periodontal disease and diabetes mellitus: a two-way relationship. Ann Periodontol 3:51–61

    Article  PubMed  CAS  Google Scholar 

  • Han YW, Redline RW, Li M, Yin L, Hill GB, McCormick TS (2004) Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. Infect Immun 72:2272–2279

    Article  PubMed  CAS  Google Scholar 

  • Han YW, Shen T, Chung P, Buhimschi IA, Buhimschi CS (2009) Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. J Clin Microbiol 47:38–47

    Article  PubMed  Google Scholar 

  • Han YW, Fardini Y, Chen C, Iacampo KG, Peraino VA, Shamonki JM, Redline RW (2010) Term stillbirth caused by oral Fusobacterium nucleatum. Obstet Gynecol 115:442–445

    Article  PubMed  Google Scholar 

  • Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, Van Dyke TE (2007) Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol 179:7021–7029

    PubMed  CAS  Google Scholar 

  • Heddle C, Nobbs AH, Jakubovics NS, Gal M, Mansell JP, Dymock D, Jenkinson HF (2003) Host collagen signal induces antigen I/II adhesin and invasin gene expression in oral Streptococcus gordonii. Mol Microbiol 50:597–607

    Article  PubMed  CAS  Google Scholar 

  • Ikegami A, Chung P, Han YW (2009) Complementation of the fadA mutation in Fusobacterium nucleatum demonstrates that the surface-exposed adhesin promotes cellular invasion and placental colonization. Infect Immun 77:3075–3079

    Article  PubMed  CAS  Google Scholar 

  • Izumi Y, Sugiyama S, Shinozuka O, Yamazaki T, Ohyama T, Ishikawa I (1989) Defective neutrophil chemotaxis in Down’s syndrome patients and its relationship to periodontal destruction. J Periodontol 60:238–242

    Article  PubMed  CAS  Google Scholar 

  • Jenkinson HF (1994) Adherence and accumulation of oral streptococci. Trends Microbiol 2:209–212

    Article  PubMed  CAS  Google Scholar 

  • Kantarci A, Oyaizu K, Van Dyke TE (2003) Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis. J Periodontol 74:66–75

    Article  PubMed  CAS  Google Scholar 

  • Keijser BJ, Zaura E, Huse SM, van der Vossen JM, Schuren FH, Montijn RC, ten Cate JM, Crielaard W (2008) Pyrosequencing analysis of the oral microflora of healthy adults. J Dent Res 87:1016–1020

    Article  PubMed  CAS  Google Scholar 

  • Kolenbrander PE, London J (1993) Adhere today, here tomorrow: oral bacterial adherence. J Bacteriol 175:3247–3252

    PubMed  CAS  Google Scholar 

  • Kolenbrander PE, Egland PG, Diaz PI, Palmer RJ Jr (2005) Genome-genome interactions: bacterial communities in initial dental plaque. Trends Microbiol 13:11–15

    Article  PubMed  CAS  Google Scholar 

  • Kolenbrander PE, Jakubovics NS, Bachrach G (2009) Oral microbiology. In: Schaechter M (ed) Encyclopedia of microbiology. Elsevier, Oxford, pp 566–588

    Chapter  Google Scholar 

  • Kolenbrander PE, Palmer RJ Jr, Periasamy S, Jakubovics NS (2010) Oral multispecies biofilm development and the key role of cell-cell distance. Nat Rev Microbiol 8:471–480

    Article  PubMed  CAS  Google Scholar 

  • Lamont RJ, El-Sabaeny A, Park Y, Cook GS, Costerton JW, Demuth DR (2002) Role of the Streptococcus gordonii SspB protein in the development of Porphyromonas gingivalis biofilms on streptococcal substrates. Microbiology 148:1627–1636

    PubMed  CAS  Google Scholar 

  • Li SH, Kingman A, Forthofer R, Swango P (1993) Comparison of tooth surface-specific dental caries attack patterns in US schoolchildren from two national surveys. J Dent Res 72:1398–1405

    Article  PubMed  CAS  Google Scholar 

  • Loe H, Anerud A, Boysen H, Morrison E (1986) Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. J Clin Periodontol 13:431–445

    Article  PubMed  CAS  Google Scholar 

  • Marsh PD (1994) Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res 8:263–271

    PubMed  CAS  Google Scholar 

  • Moberg Skold U, Petersson LG, Lith A, Birkhed D (2005) Effect of school-based fluoride varnish programmes on approximal caries in adolescents from different caries risk areas. Caries Res 39:273–279

    Article  PubMed  Google Scholar 

  • Nyvad B, Kilian M (1987) Microbiology of the early colonization of human enamel and root surfaces In vivo. Scand J Dent Res 95:369–380

    PubMed  CAS  Google Scholar 

  • Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, McKaig R, Beck J (1996) Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol 67:1103–1113

    PubMed  CAS  Google Scholar 

  • Palmer RJ Jr (1999) Microscopy flowcells: perfusion chambers for real-time study of biofilms. Method Enzymol 310:160–166

    Article  Google Scholar 

  • Palmer RJ Jr, Wu R, Gordon S, Bloomquist CG, Liljemark WF, Kilian M, Kolenbrander PE (2001) Retrieval of biofilms from the oral cavity. Method Enzymol 337:393–403

    Article  Google Scholar 

  • Palmer RJ Jr, Gordon SM, Cisar JO, Kolenbrander PE (2003) Coaggregation-mediated interactions of streptococci and actinomyces detected in initial human dental plaque. J Bacteriol 185:3400–3409

    Article  PubMed  CAS  Google Scholar 

  • Paster BJ, Russell MK, Alpagot T, Lee AM, Boches SK, Galvin JL, Dewhirst FE (2002) Bacterial diversity in necrotizing ulcerative periodontitis in HIV-positive subjects. Ann Periodontol 7:8–16

    Article  PubMed  Google Scholar 

  • Paster BJ, Olsen I, Aas JA, Dewhirst FE (2006) The breadth of bacterial diversity in the human periodontal pocket and other oral sites. Periodontol 2000 42:80–87

    Article  PubMed  Google Scholar 

  • Periasamy S, Kolenbrander PE (2009a) Aggregatibacter actinomycetemcomitans builds mutualistic biofilm communities with Fusobacterium nucleatum and Veillonella species in saliva. Infect Immun 77:3542–3551

    Article  PubMed  CAS  Google Scholar 

  • Periasamy S, Kolenbrander PE (2009b) Mutualistic biofilm communities develop with Porphyromonas gingivalis and initial, early and late colonizers of enamel. J Bacteriol 191(22):6804–6811

    Article  PubMed  CAS  Google Scholar 

  • Periasamy S, Chalmers NI, Du-Thumm L, Kolenbrander PE (2009) Fusobacterium nucleatum ATCC 10953 requires Actinomyces naeslundii ATCC 43146 for growth on saliva in a three-species community that includes Streptococcus oralis 34. Appl Environ Microbiol 75:3250–3257

    Article  PubMed  CAS  Google Scholar 

  • Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. Lancet 366:1809–1820

    Article  PubMed  Google Scholar 

  • Rasmussen M, Li Y, Lindgreen S, Pedersen JS, Albrechtsen A, Moltke I, Metspalu M, Metspalu E, Kivisild T, Gupta R (2010) Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature 463:757–762

    Article  PubMed  CAS  Google Scholar 

  • Reynolds EC (2009) Casein phosphopeptide – amorphous calcium phosphate: the scientific evidence. Adv Dent Res 21:25–29

    Article  PubMed  CAS  Google Scholar 

  • Skjorland KK, Rykke M, Sonju T (1995) Rate of pellicle formation in vivo. Acta Odontol Scand 53:358–362

    Article  PubMed  CAS  Google Scholar 

  • Socransky SS, Smith C, Martin L, Paster BJ, Dewhirst FE, Levin AE (1994) “Checkerboard” DNA-DNA hybridization. Biotechniques 17:788–792

    PubMed  CAS  Google Scholar 

  • Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr (1998) Microbial complexes in subgingival plaque. J Clin Periodontol 25:134–144

    Article  PubMed  CAS  Google Scholar 

  • Tanzer JM (1979) Essential dependence of smooth surface caries on, and augmentation of fissure caries by, sucrose and Streptococcus mutans infection. Infect Immun 25:526–531

    PubMed  CAS  Google Scholar 

  • Vesey PM, Kuramitsu HK (2004) Genetic analysis of Treponema denticola ATCC 35405 biofilm formation. Microbiology 150:2401–2407

    Article  PubMed  CAS  Google Scholar 

  • Zaura E, Keijser BJ, Huse SM, Crielaard W (2009) Defining the healthy “core microbiome” of oral microbial communities. BMC Microbiol 9:259

    Article  PubMed  Google Scholar 

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Correspondence to Gilad Bachrach .

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Bachrach, G., Faerman, M., Ginesin, O., Eini, A., Sol, A., Coppenhagen-Glazer, S. (2012). Oral Microbes in Health and Disease. In: Rosenberg, E., Gophna, U. (eds) Beneficial Microorganisms in Multicellular Life Forms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21680-0_13

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