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Histone Deacetylases: the Biology and Clinical Implication pp 1–12Cite as

K-Acetylation and Its Enzymes: Overview and New Developments

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 206))

Abstract

Lysine (K) acetylation refers to transfer of the acetyl moiety from acetyl-CoA to the ε-amino group of a lysine residue. This is posttranslational and reversible, with its level dynamically maintained by lysine acetyltransferases (KATs) and deacetylases (KDACs). Traditionally, eukaryotic KDACs have been referred to as HDACs (histone deacetylases). Recent proteomic studies have revealed that hundreds of bacterial proteins and thousands of eukaryotic proteins contain acetyl-lysine (AcK) residues, indicating that K-acetylomes are comparable to phosphoproteomes. The current challenges are to assign enzymes that execute specific acetylation events, to determine the impact of these events, and to relate this modification to other posttranslational modifications, cell signaling networks, and pathophysiology under different cellular and developmental contexts. In this chapter, we provide a brief overview about the acetylomes, KATs, HDACs, AcK-recognizing protein domains, and acetylation-modulating therapeutics, and emphasize the latest developments in related areas. The remaining chapters of the book focus on and cover various aspects of HDACs (both the Rpd3/Hda1 and sirtuin families), which shall provide novel insights into how to utilize these enzymes for developing a new generation of HDAC-related therapeutics.

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Acknowledgments

This work was supported by operating grants from MDEIE (Développement économique, innovation et exportation) Québec, Canadian Institutes of Health Research, and Canadian Cancer Society (to X.-J.Y.).

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Authors and Affiliations

  1. The Rosalind & Morris Goodman Cancer Research Center, McGill University, Montréal, QC, Canada, H3A 1A3

    Juliette Adjo Aka, Go-Woon Kim & Xiang-Jiao Yang

  2. Department of Medicine, McGill University Health Center, McGill University, Montréal, QC, Canada, H3A 1A3

    Juliette Adjo Aka & Xiang-Jiao Yang

  3. Department of Anatomy & Cell Biology, McGill University, Montréal, QC, Canada, H3A 1A3

    Go-Woon Kim & Xiang-Jiao Yang

  4. Department of Biochemistry, McGill University, Montréal, QC, Canada, H3A 1A3

    Xiang-Jiao Yang

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  1. Juliette Adjo Aka
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Correspondence to Xiang-Jiao Yang .

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Editors and Affiliations

  1. , Department of Pharmacology, Duke University, Durham, 27710, North Carolina, USA

    Tso-Pang Yao

  2. , Department of Molecular Oncology, H.Lee Moffitt Cancer Center & Research I, Magnolia Drive 12902, Tampa, 33612, Florida, USA

    Edward Seto

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Aka, J.A., Kim, GW., Yang, XJ. (2011). K-Acetylation and Its Enzymes: Overview and New Developments. In: Yao, TP., Seto, E. (eds) Histone Deacetylases: the Biology and Clinical Implication. Handbook of Experimental Pharmacology, vol 206. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21631-2_1

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