Abstract
Evidence about the striking relation between the geometric features of the cerebral cortex and cognitive/healthy states of corresponding individuals has being widely reported for different mammalian species, including humans. In this study we evaluated four different geometric features (Average Fractal Dimension, Watershed Regions, Gyrification Index and Absolute Mean Curvature) on the cortex of six healthy mouse brains (C3HeB), based on their corresponding high resolution MR images. Each measure was evaluated firstly on the entire individual’s cerebral cortex, latter on both hemispheres and finally on a set of redefined cortical regions (with a similar volume). In all cases was obtained a low variation through subjects, which is expected due to we are working with healthy subjects at a similar age. In addition, we found that different brain regions presents different geometric properties, which is in correspondence with the different local properties of the cerebral cortex, that responds to the main principle of brain segregation. Future works should be focused on the evaluation through these measures of global and local structural brain affectations provoked by pathological states.
Finally, the obtained measures for the whole brain and both hemispheres were compared with the equivalent values obtained for 10 healthy human brains. Results indicated significant lower values for mouse brains, which should be respond-ing to the expected superior complexity of the human brain.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Berlin Heidelberg
About this paper
Cite this paper
Ontivero-Ortega, M., Iturria-Medina, Y., Melie-García, L., Aubert-Vázquez, E. (2013). Evaluation of Different Geometric Features on the Cerebral Cortex of the Healthy Mouse. In: Folgueras Méndez, J., et al. V Latin American Congress on Biomedical Engineering CLAIB 2011 May 16-21, 2011, Habana, Cuba. IFMBE Proceedings, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21198-0_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-21198-0_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-21197-3
Online ISBN: 978-3-642-21198-0
eBook Packages: EngineeringEngineering (R0)