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Selenium and Human Health: Snapshots from the Frontiers of Selenium Biomedicine

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Book cover Selenium and Tellurium Chemistry

Abstract

Recent results and current research activities in selenium biochemistry are compiled and discussed in respect to their relevance to human pathology, alimentary requirements and the potential benefit of selenium supplementation. Particular emphasis is laid on the relevance of selenium transport to tissue specific functions, unexpected roles of seemingly well understood selenoproteins, and potential roles of less characterized ones. By re-viewing of experimental and clinical data, it is concluded that an adequate nutritional intake of selenium likely contributes to prevention of carcinogenesis, cardiovascular, inflammatory and neuro-degenerative diseases and positively affects the outcome of infections, while any Se supplementation far beyond the Daily Reference Intakes failed to yield any health benefit. However, special Se requirements are anticipated for genetic variants in selenoprotein genes, selenoprotein synthesis and the Se transport system.

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  1. Department of Chemistry, Otto-von-Guerricke-Universität Madgeburg, Magdeburg, Germany

    Leopold Flohé

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    J. Derek Woollins

  2. , Dept. of Chemistry, University of Oulu, PO Box 3000, Oulu, 90014, Finland

    Risto Laitinen

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Flohé, L. (2011). Selenium and Human Health: Snapshots from the Frontiers of Selenium Biomedicine. In: Woollins, J., Laitinen, R. (eds) Selenium and Tellurium Chemistry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20699-3_12

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