Abstract
The fundamental principal of gene therapy is the transfer of genetic material into individuals for therapeutic purposes by altering cellular function or structure at the molecular level. The genetic alteration ultimately leads to the production of a therapeutic protein that is secreted into the surrounding tissue milieu, is expressed on the cell surface or acts as a signaling molecule to influence cell or tissue behavior. Genetic engineering and the use of adult stem cells may hold the key to future development of tissue-engineered constructs. The identification or perhaps deletion of specific genetic sequences might be able to identify and modify genes critical to tissue development. The overall safety of the various gene delivery systems is also an important consideration. Clearly, many hurdles remain to be addressed before these approaches can be widely applied as a common therapeutic strategy.
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References
Bennett JH et al (1991) Adipocytic cells cultured from marrow have osteogenic potential. J Cell Sci 99(pt 1):131–139
Bonadio J (2000) Tissue engineering via local gene delivery: update and future prospects for enhancing the technology. Adv Drug Deliv Rev 44(2-3):185–194
Bonadio J (2002) Genetic approaches to tissue repair. Ann NY Acad Sci 961:58–60
Bonadio J et al (1999) Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat Med 5(7):753–759
Bruder SP, Fink DJ, Caplan AI (1994) Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56(3):283–294
Bruder SP, Jaiswal N, Haynesworth SE (1997) Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem 64(2):278–294
Burton EA, Glorioso JC, Fink DJ (2003) Gene therapy progress and prospects: Parkinson’s disease. Gene Ther 10(20):1721–1727
Chamberlain JR et al (2004) Gene targeting in stem cells from individuals with osteogenesis imperfecta. Science 303(5661):1198–1201
Chen HK et al (2005) Combined cord blood stem cells and gene therapy enhances angiogenesis and improves cardiac performance in mouse after acute myocardial infarction. Eur J Clin Invest 35(11):677–686
Crystal RG (1995) Transfer of genes to humans: early lessons and obstacles to success. Science 270(5235):404–410
Danos O, Heard JM (1992) Recombinant retroviruses as tools for gene transfer to somatic cells. Bone Marrow Transplant 9(suppl 1):131–138
De Ugarte DA et al (2003) Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs 174(3):101–109
Evans CH, Robbins PD (1995) Possible orthopaedic applications of gene therapy. J Bone Joint Surg Am 77(7):1103–1114
Galotto M et al (1994) Hypertrophic chondrocytes undergo further differentiation to osteoblast-like cells and participate in the initial bone formation in developing chick embryo. J Bone Miner Res 9(8):1239–1249
Goessler UR, Hormann K, Riedel F (2004) Tissue engineering with chondrocytes and function of the extracellular matrix (review). Int J Mol Med 13(4):505–513
Goessler UR, Hormann K, Riedel F (2005) Tissue engineering with adult stem cells in reconstructive surgery (review). Int J Mol Med 15(6):899–905
Goessler UR et al (2006) Perspectives of gene therapy in stem cell tissue engineering. Cells Tissues Organs 183(4):169–179
Goff SP, Lobel LI (1987) Mutants of murine leukemia viruses and retroviral replication. Biochim Biophys Acta 907(2):93–123
Hall PA, Watt FM (1989) Stem cells: the generation and maintenance of cellular diversity. Development 106(4):619–633
Hammerling GJ, Ganss R (2006) Vascular integration of endothelial progenitors during multistep tumor progression. Cell Cycle 5(5):509–511
Korbling M, Estrov Z (2003) Adult stem cells for tissue repair–a new therapeutic concept? N Engl J Med 349(6):570–582
Korbling M, Estrov Z, Champlin R (2003) Adult stem cells and tissue repair. Bone Marrow Transplant 32(suppl 1):S23–S24
Krisky DM et al (1998) Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications. Gene Ther 5(11):1517–1530
Krisky DM et al (1998) Deletion of multiple immediate-early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons. Gene Ther 5(12):1593–1603
Krougliak V, Graham FL (1995) Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutants. Hum Gene Ther 6(12):1575–1586
Levitus M, Joenje H, de Winter JP (2006) The Fanconi anemia pathway of genomic maintenance. Cell Oncol 28(1–2):3–29
Lucas WT, Youngner JS (1992) The use of hybrid-selected template increases the specificity of the polymerase chain reaction. PCR Meth Appl 2(1):41–44
Marshall E (2000) Improving gene therapy’s tool kit. Science 288(5468):953
Marshall E (2002) Clinical research. Gene therapy a suspect in leukemia-like disease. Science 298(5591):34–35
Oligino TJ et al (2000) Vector systems for gene transfer to joints. Clin Orthop Relat Res 379(suppl):S17–S30
Parker AM, Katz AJ (2006) Adipose-derived stem cells for the regeneration of damaged tissues. Expert Opin Biol Ther 6(6):567–578
Pittenger MF et al (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143–147
Reyes M et al (2002) Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest 109(3):337–346
Robbins PD, Ghivizzani SC (1998) Viral vectors for gene therapy. Pharmacol Ther 80(1):35–47
Salyapongse AN, Billiar TR, Edington H (1999) Gene therapy and tissue engineering. Clin Plast Surg 26(4):663–676, x
Stock UA, Vacanti JP (2001) Tissue engineering: current state and prospects. Annu Rev Med 52:443–451
Toma JG et al (2001) Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 3(9):778–784
Warren SM et al (2002) New directions in bioabsorbable technology. J Neurosurg 97(4 suppl):481–489
Young LS et al (2006) Viral gene therapy strategies: from basic science to clinical application. J Pathol 208(2):299–318
Zuk PA et al (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7(2):211–228
Zuk PA et al (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13(12):4279–4295
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© 2011 Springer-Verlag Berlin Heidelberg
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Goessler, U.R. (2011). Gene Therapy Used for Adipose Stem Cell Engineering. In: Illouz, YG., Sterodimas, A. (eds) Adipose Stem Cells and Regenerative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20012-0_11
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DOI: https://doi.org/10.1007/978-3-642-20012-0_11
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