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10 Evolution of Genes for Secondary Metabolism in Fungi

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Evolution of Fungi and Fungal-Like Organisms

Part of the book series: The Mycota ((MYCOTA,volume 14))

Abstract

Fungal secondary metabolites are a group of chemically highly diverse molecules, many of which are noted for their pharmacological or toxic potential. Genetic studies have already unraveled a number of biochemical pathways that are involved in the production of typical fungal secondary metabolites (e.g., polyketides, nonribosomal peptides, alkaloids, terpenes). However, recent advances in genome sequencing indicate that the number of genes potentially involved in the biosynthesis of secondary metabolites is much larger than the number of known metabolites. These findings raise the questions of how and why fungi evolved so many genes for the production of secondary metabolites. In this review, we give an overview of secondary metabolite genes in different fungal groups, address some of the principles of the regulation of expression of these genes, and summarize what is known about the biological functions of secondary metabolites in fungi.

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References

  • Akamatsu HO, Chilvers MI, Stewart JE, Peever TL (2010) Identification and function of a polyketide synthase gene responsible for 1,8-dihydroxynaphthalene-melanin pigment biosynthesis in Ascochyta rabiei. Curr Genet (in press)

    Google Scholar 

  • Alviano CS, Farbiarz SR, De Souza W, Angluster J, Travassos LR (1991) Characterization of Fonsecaea pedrosoi melanin. J Gen Microbiol 137:837–844

    Article  PubMed  CAS  Google Scholar 

  • Austin MB, Saito T, Bowman ME, Haydock S, Kato A, Moore BS, Kay RR, Noel JP (2006) Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nat Chem Biol 2:494–502

    Article  PubMed  CAS  Google Scholar 

  • Baker SE, Kroken S, Inderbitzin P, Asvarak T, Li BY, Shi L, Yoder OC, Turgeon BG (2006) Two polyketide synthase-encoding genes are required for biosynthesis of the polyketide virulence factor, T-toxin, by Cochliobolus heterostrophus. Mol Plant Microbe Interact 19:139–149

    Article  PubMed  CAS  Google Scholar 

  • Baldrian P (2006) Fungal laccases – occurrence and properties. FEMS Microbiol Rev 30:215–242

    Article  PubMed  CAS  Google Scholar 

  • Bayram Ö, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon N-J, Keller NP, Yu J-H, Braus GH (2008) VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 320:1504–1506

    Article  PubMed  CAS  Google Scholar 

  • Bell AA, Puhalla JE, Tolmsoff WJ, Stipanovic RD (1976) Use of mutants to establish (+)-scytalone as an intermediate in melanin biosynthesis by Verticillium dahliae. Can J Microbiol 22:787–799

    Article  PubMed  CAS  Google Scholar 

  • Bell AA, Wheeler MH (1986) Biosynthesis and functions of fungal melanins. Annu Rev Phytopathol 24:411–451

    Article  CAS  Google Scholar 

  • Bennett JW, Klich M (2003) Mycotoxins. Clin Microbiol Rev 16:497–516

    Article  PubMed  CAS  Google Scholar 

  • Böhnert HU, Fudal I, Dioh W, Tharreau D, Notteghem JL, Lebrun MH (2004) A putative polyketide synthase/peptide synthetase from Magnaporthe grisea signals pathogen attack to resistant rice. Plant Cell 16:2499–2513

    Article  PubMed  Google Scholar 

  • Bok JW, Keller NP (2004) LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell 3:527–535

    Article  PubMed  CAS  Google Scholar 

  • Bok JW, Hoffmeister D, Maggio-Hall LA, Murillo R, Glasner JD, Keller NP (2006a) Genomic mining for Aspergillus natural products. Chem Biol 13:31–37

    Article  PubMed  CAS  Google Scholar 

  • Bok JW, Noordermeer D, Kale SP, Keller NP (2006b) Secondary metabolic gene cluster silencing in Aspergillus nidulans. Mol Microbiol 61:1636–1645

    Article  PubMed  CAS  Google Scholar 

  • Bok JW, Chiang Y-M, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo H-C, Watanabe K, Strauss J, Oakley BR, Wang CCC, Keller NP (2009) Chromatin-level regulation of biosynthetic gene clusters. Nat Chem Biol 5:462–464

    Article  PubMed  CAS  Google Scholar 

  • Bölker M, Basse CW, Schirawski J (2008) Ustilago maydis secondary metabolism – From genomics to biochemistry. Fungal Genet Biol 45:S88–S93

    Article  PubMed  CAS  Google Scholar 

  • Bömke C, Rojas MC, Gong F, Hedden P, Tudzynski B (2008) Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola. Appl Environ Microbiol 74:5325–5339

    Article  PubMed  CAS  Google Scholar 

  • Bömke C, Tudzynski B (2009) Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria. Phytochemistry 70:1876–1893

    Article  PubMed  CAS  Google Scholar 

  • Borkovich KA, Alex LA, Yarden O, Freitag M, Turner GE, Read ND, Seiler S, Bell-Pedersen D, Paietta J, Plesofsky N, Plamann M, Goodrich-Tanrikulu M, Schulte U, Mannhaupt G, Nargang FE, Radford A, Selitrennikoff C, Galagan JE, Dunlap JC, Loros JJ, Catcheside D, Inoue H, Aramayo R, Polymenis M, Selker EU, Sachs MS, Marzluf GA, Paulsen I, Davis R, Ebbole DJ, Zelter A, Kalkman ER, O'Rourke R, Bowring F, Yeadon J, Ishii C, Suzuki K, Sakai W, Pratt R (2004) Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev 68:1–108

    Article  PubMed  CAS  Google Scholar 

  • Brakhage AA, Langfelder K, Wanner G, Schmidt A, Jahn B (1999) Pigment biosynthesis and virulence. Contrib Microbiol 2:205–215

    Article  PubMed  CAS  Google Scholar 

  • Brakhage AA, Thön M, Spröte P, Scharf DH, Al-Abdallah Q, Wolke SM, Hortschansky P (2009) Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors. Phytochemistry 70:1801–1811

    Article  PubMed  CAS  Google Scholar 

  • Brakhage AA, Schroeckh V (2010) Fungal secondary metabolites – Strategies to activate silent gene clusters. Fungal Genet Biol In Press:doi:10.1016/j.fgb.2010.04.004

  • Brown DW, Dyer RB, McCormick SP, Kendra DF, Plattner RD (2004) Functional demarcation of the Fusarium core trichothecene gene cluster. Fungal Genet Biol 41:454–462

    Article  PubMed  CAS  Google Scholar 

  • Buades C, Moya A (1996) Phylogenetic analysis of the isopenicillin-N-synthetase horizontal gene transfer. J Mol Evol 45:537–542

    Article  Google Scholar 

  • Bushley KE, Ripoll DR, Turgeon BG (2008) Module evolution and substrate specificity of fungal nonribosomal peptide synthetases involved in siderophore biosynthesis. BMC Evol Biol 8:328

    Article  PubMed  CAS  Google Scholar 

  • Bushley KE, Turgeon BG (2010) Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships. BMC Evol Biol 10:26

    Article  PubMed  CAS  Google Scholar 

  • Butler MJ, Lazarovits G, Higgins VJ, Lachance MA (1989) Identification of a Black Yeast Isolated from Oak Bark as Belonging to the Genus Phaeococcomyces sp. Analysis of Melanin Produced by the Yeast. Can J Microbiol 35:728–734

    Article  CAS  Google Scholar 

  • Butler MJ, Day AW (1998) Fungal melanins: a review. Can J Microbiol 44:1115–1136

    Article  CAS  Google Scholar 

  • Butler MJ, Day AW, Henson JM, Money NP (2001) Pathogenic properties of fungal melanins. Mycologia 93:1–8

    Article  CAS  Google Scholar 

  • Butler MJ, Gardiner RB, Day AW (2009) Melanin synthesis by Sclerotinia sclerotiorum. Mycologia 101:296–304

    Article  PubMed  CAS  Google Scholar 

  • Caesar-Tonthat T, Van Ommen KF, Geesey GG, Henson JM (1995) Melanin production by a filamentous soil fungus in response to copper and localization of copper sulfide by sulfide-silver staining. Appl Env Microbiol 61:1968–1975

    CAS  Google Scholar 

  • Calvo AM, Wilson RA, Bok JW, Keller NP (2002) Relationship between secondary metabolism and fungal development. Microbiol Mol Biol Rev 66:447–459

    Article  PubMed  CAS  Google Scholar 

  • Casadevall A, Rosas AL, Nosanchuk JD (2000) Melanin and virulence in Cryptococcus neoformans. Current Opinion in Microbiology 3:354–358

    Article  PubMed  CAS  Google Scholar 

  • Chai LY, Netea MG, Sugui J, Vonk AG, van de Sande WW, Warris A, Kwon-Chung KJ, Jan Kullberg B (2009) Aspergillus fumigatus conidial melanin modulates host cytokine response. Immunobiology (in press)

    Google Scholar 

  • Choquer M, Dekkers KL, Chen H-Q, Cao L, Ueng PP, Daub ME, Chung K-R (2005) The CTB1 gene encoding a fungal polyketide synthase is required for cercosporin biosynthesis and fungal virulence of Cercospora nicotianae. Mol Plant Microbe Interact 18:468–476

    Article  PubMed  CAS  Google Scholar 

  • Chumley FG, Valent B (1990) Genetic analysis of melanin-deficient, nonpathogenic mutants of Magnaporthe grisea. Mol Plant Microbe Interact 3:135–143

    Article  CAS  Google Scholar 

  • Claus H, Decker H (2006) Bacterial tyrosinases. Syst Appl Microbiol 29:3–14

    Article  PubMed  CAS  Google Scholar 

  • Coleman JJ, Rounsley SD, Rodriguez-Carres M, Kuo A, Wasmann CC, Grimwood J, Schmutz J, Taga M, White GJ, Zhou S, Schwartz DC, Freitag M, Ma L-j, Danchin EGJ, Henrissat B, Coutinho PM, Nelson DR, Straney D, Napoli CA, Barker BM, Gribskov M, Rep M, Kroken S, Molnár In, Rensing C, Kennell JC, Zamora J, Farman ML, Selker EU, Salamov A, Shapiro H, Pangilinan J, Lindquist E, Lamers C, Grigoriev IV, Geiser DM, Covert SF, Temporini E, VanEtten HD (2009) The genome of Nectria haematococca: Contribution of supernumerary chromosomes to gene expansion. PLoS Genet 5:e1000618

    Article  PubMed  CAS  Google Scholar 

  • Collemare J, Pianfetti M, Houlle A-E, Morin D, Camborde L, Gagey M-J, Barbisan C, Fudal I, Lebrun M-H, Böhnert HU (2008) Magnaporthe grisea avirulence gene ACE1 belongs to an infection-specific gene cluster involved in secondary metabolism. New Phytol 179:196–208

    Article  PubMed  CAS  Google Scholar 

  • Coppin E, Silar P (2007) Identification of PaPKS1, a polyketide synthase involved in melanin formation and its use as a genetic tool in Podospora anserina. Mycol Res 111:901–908

    Article  PubMed  CAS  Google Scholar 

  • Cox RJ (2007) Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets. Org Biomol Chem 5:2010–2026

    Article  PubMed  CAS  Google Scholar 

  • Cunha MM, Franzen AJ, Alviano DS, Zanardi E, Alviano CS, De Souza W, Rozental S (2005) Inhibition of melanin synthesis pathway by tricyclazole increases susceptibility of Fonsecaea pedrosoi against mouse macrophages. Microsc Res Tech 68:377–384

    Article  PubMed  CAS  Google Scholar 

  • Cuomo CA, Güldener U, Xu JR, Trail F, Turgeon BG, Di Pietro A, Walton JD, Ma LJ, Baker SE, Rep M, Adam G, Antoniw J, Baldwin T, Calvo S, Chang YL, Decaprio D, Gale LR, Gnerre S, Goswami RS, Hammond-Kosack K, Harris LJ, Hilburn K, Kennell JC, Kroken S, Magnuson JK, Mannhaupt G, Mauceli E, Mewes HW, Mitterbauer R, Muehlbauer GJ, Münsterkötter M, Nelson D, O'donnell K, Ouellet T, Qi W, Quesneville H, Roncero MI, Seong KY, Tetko IV, M. U, Waalwijk C, Ward TJ, Yao J, Birren BW, Kistler HC (2007) The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. Science 317:1400–1402

    Article  PubMed  CAS  Google Scholar 

  • da Silva MB, Marques AF, Nosanchuk JD, Casadevall A, Travassos LR, Taborda CP (2006) Melanin in the dimorphic fungal pathogen Paracoccidioides brasiliensis: effects on phagocytosis, intracellular resistance and drug susceptibility. Microbes Infect 8:197–205

    Article  PubMed  CAS  Google Scholar 

  • Dadachova E, Bryan RA, Huang X, Moadel T, Schweitzer AD, Aisen P, Nosanchuk JD, Casadevall A (2007) Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi. PLoS One 2:e457

    Article  PubMed  CAS  Google Scholar 

  • Dadachova E, Casadevall A (2008) Ionizing radiation: how fungi cope, adapt, and exploit with the help of melanin. Curr Opin Microbiol 11:525–531

    Article  PubMed  CAS  Google Scholar 

  • de Jong JC, McCormack BJ, Smirnoff N, Talbot NJ (1997) Glycerol generates turgor in rice blast. Nature 389:244–244

    Article  CAS  Google Scholar 

  • Dean RA, Talbot NJ, Ebbole DJ, Farman ML, Mitchell TK, Orbach MJ, Thon M, Kulkarni R, Xu J-R, Pan H, Read ND, Lee Y-H, Carbone I, Brown D, Oh YY, Donofrio N, Jeong JS, Soanes DM, Djonovic S, Kolomiets E, Rehmeyer C, Li W, Harding M, Kim S, Lebrun M-H, Bohnert H, Coughlan S, Butler J, Calvo S, Ma L-J, Nicol R, Purcell S, Nusbaum C, Galagan JE, Birren BW (2005) The genome sequence of the rice blast fungus Magnaporthe grisea. Nature 434:980–986

    Article  PubMed  CAS  Google Scholar 

  • Dighton J, Tugay T, Zhdanova N (2008) Fungi and ionizing radiation from radionuclides. FEMS Microbiol Lett 281:109–120

    Article  PubMed  CAS  Google Scholar 

  • Ding Y, Williams RM, Sherman DH (2008) Molecular analysis of a 4-dimethylallyltryptophan synthase from Malbranchea aurantiaca. J Biol Chem 283:16068–16076

    Article  PubMed  CAS  Google Scholar 

  • Dittmer NT, Kanost MR (2010) Insect multicopper oxidases: diversity, properties, and physiological roles. Insect Biochem Mol Biol 40:179–188

    Article  PubMed  CAS  Google Scholar 

  • Eichinger L, Pachebat JA, Glockner G, Rajandream MA, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov BA, Rivero F, Bankier AT, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail MA, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox EC, Chisholm RL, Gibbs R, Loomis WF, Platzer M, Kay RR, Williams J, Dear PH, Noegel AA, Barrell B, Kuspa A (2005) The genome of the social amoeba Dictyostelium discoideum. Nature 435:43–57

    Article  PubMed  CAS  Google Scholar 

  • Eisendle M, Oberegger H, Zadra I, Haas H (2003) The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5-monooxygenase (sidA) and a non-ribosomal peptide synthetase (sidC). Mol Microbiol 49:359–375

    Article  PubMed  CAS  Google Scholar 

  • Eisendle M, Schrettl M, Kragl C, Muller D, Illmer P, Haas H (2006) The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans. Eukaryot Cell 5:1596–1603

    Article  PubMed  CAS  Google Scholar 

  • Elliott CE, Gardiner DM, Thomas G, Cozijnsen A, Van De Wouw A, Howlett BJ (2007) Production of the toxin sirodesmin PL by Leptosphaeria maculans during infection of Brassica napus. Mol Plant Pathol 8:791–802

    Article  PubMed  CAS  Google Scholar 

  • Engh I, Nowrousian M, Kück U (2007) Regulation of melain biosynthesis via the dihydroxynaphtalene pathway is dependent on sexual development in the ascomycete Sordaria macrospora. FEMS Microbiol Lett 275:62–70

    Article  PubMed  CAS  Google Scholar 

  • Espagne E, Lespinet O, Malagnac F, Da Silva C, Jaillon O, Porcel B, Couloux A, Aury J-M, Segurens B, Poulain J, Anthouard V, Grossetete S, Khalili H, Coppin E, Dequard-Chablat M, Picard M, Contamine V, Arnaise S, Bourdais A, Berteaux-Lecellier V, Gautheret D, de Vries R, Battaglia E, Coutinho P, Danchin E, Henrissat B, Khoury R, Sainsard-Chanet A, Boivin A, Pinan-Lucarre B, Sellem C, Debuchy R, Wincker P, Weissenbach J, Silar P (2008) The genome sequence of the model ascomycete fungus Podospora anserina. Genome Biol 9:R77

    Article  PubMed  CAS  Google Scholar 

  • Esser K (1966) Die Phenoloxidasen des Ascomyceten Podospora anserina. III. Quantitative und qualitative Enzymunterschiede nach Mutation an nicht gekoppelten Loci. Zeitschrift für Vererbungslehre 97:327–344

    CAS  Google Scholar 

  • Esser K (1968) Phenol oxidases and morphogenesis in Podospora anserina. Genetics 60:281–288

    PubMed  CAS  Google Scholar 

  • Fedorova ND, Khaldi N, Joardar VS, Maiti R, Amedeo P, Anderson MJ, Crabtree J, Silva JC, Badger JH, Albarraq A, Angiuoli S, Bussey H, Bowyer P, Cotty PJ, Dyer PS, Egan A, Galens K, Fraser-Liggett CM, Haas BJ, Inman JM, Kent R, Lemieux S, Malavazi I, Orvis J, Roemer T, Ronning CM, Sundaram JP, Sutton G, Turner G, Venter JC, White OR, Whitty BR, Youngman P, Wolfe KH, Goldman GH, Wortman JR, Jiang B, Denning DW, Nierman WC (2008) Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. PLOS Genet 4:e1000046

    Article  PubMed  CAS  Google Scholar 

  • Fernandes M, Keller NP, Adams TH (1998) Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis. Mol Microbiol 28:1355–1365

    Article  PubMed  CAS  Google Scholar 

  • Flores-Sanchez IJ, Verpoorte R (2009) Plant polyketide synthases: a fascinating group of enzymes. Plant Physiol Biochem 47:167–174

    Article  PubMed  CAS  Google Scholar 

  • Fox EM, Howlett BJ (2008) Secondary metabolism: regulation and role in fungal biology. Curr Opin Microbiol 11:481–487

    Article  PubMed  CAS  Google Scholar 

  • Franzen AJ, Cunha MM, Miranda K, Hentschel J, Plattner H, da Silva MB, Salgado CG, de Souza W, Rozental S (2008) Ultrastructural characterization of melanosomes of the human pathogenic fungus Fonsecaea pedrosoi. J Struct Biol 162:75–84

    Article  PubMed  CAS  Google Scholar 

  • Frases S, Chaskes S, Dadachova E, Casadevall A (2006) Induction by Klebsiella aerogenes of a melanin-like pigment in Cryptococcus neoformans. Appl Environ Microbiol 72:1542–1550

    Article  PubMed  CAS  Google Scholar 

  • Frases S, Salazar A, Dadachova E, Casadevall A (2007) Cryptococcus neoformans can utilize the bacterial melanin precursor homogentisic acid for fungal melanogenesis. Appl Environ Microbiol 73:615–621

    Article  PubMed  CAS  Google Scholar 

  • Friesen TL, Stukenbrock EH, Liu Z, Meinhardt S, Ling H, Faris JD, Rasmussen JC, Solomon PS, McDonald BA, Oliver RP (2006) Emergence of a new disease as a result of interspecific virulence gene transfer. Nat Genet 38:953–956

    Article  PubMed  CAS  Google Scholar 

  • Fujihara N, Sakaguchi A, Tanaka S, Fujii S, Tsuji G, Shiraishi T, O'Connell R, Kubo Y (2010) Peroxisome biogenesis factor PEX13 is required for appressorium-mediated plant infection by the anthracnose fungus Colletotrichum orbiculare. Mol Plant Microbe Interact 23:436–445

    Article  PubMed  CAS  Google Scholar 

  • Fujii I, Yasuoka Y, Tsai HF, Chang YC, Kwon-Chung KJ, Ebizuka Y (2004) Hydrolytic polyketide shortening by Ayg1p, a novel enzyme involved in fungal melanin biosynthesis. J Biol Chem 279:44613–44620

    Article  PubMed  CAS  Google Scholar 

  • Fulton TR, Ibrahim N, Losada MC, Grzegorski D, Tkacz JS (1999) A melanin polyketide synthase (PKS) gene from Nodulisporium sp. that shows homology to the pks1 gene of Colletotrichum lagenarium. Mol Gen Genet 262:714–720

    Article  PubMed  CAS  Google Scholar 

  • Funa N, Awakawa T, Horinouchi S (2007) Pentaketide resorcylic acid synthesis by type III polyketide synthase from Neurospora crassa. J Biol Chem 282:14476–14481

    Article  PubMed  CAS  Google Scholar 

  • Gachomo EW, Seufferheld MJ, Kotchoni SO (2010) Melanization of appressoria is critical for the pathogenicity of Diplocarpon rosae. Mol Biol Rep DOI 10.1007/s11033-010-0007-4:

    Google Scholar 

  • Gaffoor I, Brown DW, Plattner R, Proctor RH, Qi W, Trail F (2005) Functional analysis of the polyketide synthase genes in the filamentous fungus Gibberella zeae (anamorph Fusarium graminearum). Eukaryot Cell 4:1926–1933

    Article  PubMed  CAS  Google Scholar 

  • Galagan JE, Calvo SE, Borkovich KA, Selker EU, Read ND, Jaffe D, FitzHugh W, Ma LJ, Smirnov S, Purcell S, Rehman B, Elkins T, Engels R, Wang S, Nielsen CB, Butler J, Endrizzi M, Qui D, Ianakiev P, Bell-Pedersen D, Nelson MA, Werner-Washburne M, Selitrennikoff CP, Kinsey JA, Braun EL, Zelter A, Schulte U, Kothe GO, Jedd G, Mewes W, Staben C, Marcotte E, Greenberg D, Roy A, Foley K, Naylor J, Stange-Thomann N, Barrett R, Gnerre S, Kamal M, Kamvysselis M, Mauceli E, Bielke C, Rudd S, Frishman D, Krystofova S, Rasmussen C, Metzenberg RL, Perkins DD, Kroken S, Cogoni C, Macino G, Catcheside D, Li W, Pratt RJ, Osmani SA, DeSouza CP, Glass L, Orbach MJ, Berglund JA, Voelker R, Yarden O, Plamann M, Seiler S, Dunlap JC, Radford A, Aramayo R, Natvig DO, Alex LA, Mannhaupt G, Ebbole DJ, Freitag M, Paulsen I, Sachs MS, Lander ES, Nusbaum C, Birren B (2003) The genome sequence of the filamentous fungus Neurospora crassa. Nature 422:859–868

    Article  PubMed  CAS  Google Scholar 

  • Galagan JE, Calvo SE, Cuomo C, Ma L-J, Wortman JR, Batzoglou S, Lee S-I, Basturkmen M, Spevak CC, Clutterbuck J, Kapitonov V, Jurka J, Scazzocchio C, Farman M, Butler J, Purcell S, Harris S, Braus GH, Draht O, Busch S, D'Enfert C, Bouchier C, Goldman GH, Bell-Pedersen D, Griffiths-Jones S, Doonan JH, Yu J, Vienken K, Pain A, Freitag M, Selker EU, Archer DB, Penalva MA, Oakley BR, Momany M, Tanaka T, Kumagai T, Asai K, Machida M, Nierman WC, Denning DW, Caddick M, Hynes M, Paoletti M, Fischer R, Miller B, Dyer P, Sachs MS, Osmani SA, Birren BW (2005) Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature 438:1105–1115

    Article  PubMed  CAS  Google Scholar 

  • Gallagher RT, White EP, Mortimer PH (1981) Ryegrass staggers: isolation of potent neurotoxins lolitrem A and lolitrem B from staggers-producing pastures. N Z Vet J 29:189–190

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Vallvé S, Romeu A, Palau J (2000) Horizontal gene transfer of glycosyl hydrolases of the rumen fungi. Mol Biol Evol 17:352–361

    Article  PubMed  Google Scholar 

  • Gardiner DM, Cozijnsen AJ, Wilson LM, Pedras MSC, Howlett BJ (2004) The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans. Mol Microbiol 53:1307–1318

    Article  PubMed  CAS  Google Scholar 

  • Gomez BL, Nosanchuk JD, Diez S, Youngchim S, Aisen P, Cano LE, Restrepo A, Casadevall A, Hamilton AJ (2001) Detection of melanin-like pigments in the dimorphic fungal pathogen Paracoccidioides brasiliensis in vitro and during infection. Infect Immun 69:5760–5767

    Article  PubMed  CAS  Google Scholar 

  • Gomez BL, Nosanchuk JD (2003) Melanin and fungi. Curr Opin Infect Dis 16:91–96

    Article  PubMed  CAS  Google Scholar 

  • Gostincar C, Grube M, de Hoog S, Zalar P, Gunde-Cimerman N (2010) Extremotolerance in fungi: evolution on the edge. FEMS Microbiol Ecol 71:2–11

    Article  PubMed  CAS  Google Scholar 

  • Haarmann T, Machado C, Lübbe Y, Correira T, Schardl CL, Panaccione DG, Tudzynski P (2005) The ergot alkaloid gene cluster in Claviceps purpurea: extension of the cluster sequence and intra species evolution. Phytochemistry 66:1312–1320

    Article  PubMed  CAS  Google Scholar 

  • Haarmann T, Lorenz N, Tudzynski P (2008) Use of a nonhomologous end joining deficient strain ([Delta]ku70) of the ergot fungus Claviceps purpurea for identification of a nonribosomal peptide synthetase gene involved in ergotamine biosynthesis. Fungal Genet Biol 45:35–44

    Article  PubMed  CAS  Google Scholar 

  • Haarmann T, Rolke Y, Giesbert S, Tudzynski P (2009) Ergot: from witchcraft to biotechnology. Mol Plant Pathol 10:563–577

    Article  PubMed  CAS  Google Scholar 

  • Haas H, Eisendle M, Turgeon BG (2008) Siderophores in fungal physiology and virulence. Annu Rev Phytopathol 46:149–187

    Article  PubMed  CAS  Google Scholar 

  • Halaouli S, Asther M, Sigoillot JC, Hamdi M, Lomascolo A (2006) Fungal tyrosinases: new prospects in molecular characteristics, bioengineering and biotechnological applications. J Appl Microbiol 100:219–232

    Article  PubMed  CAS  Google Scholar 

  • Hane JK, Lowe RGT, Solomon PS, Tan K-C, Schoch CL, Spatafora JW, Crous PW, Kodira C, Birren BW, Galagan JE, Torriani SFF, McDonald BA, Oliver RP (2007) Dothideomycete plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum. Plant Cell 19:3347–3368

    Article  PubMed  CAS  Google Scholar 

  • Hedden P, Kamiya Y (1997) Gibberellin biosynthesis: enzymes, genes and their regulation. Annu Rev Plant Physiol Plant Mol Biol 48:431–460

    Article  PubMed  CAS  Google Scholar 

  • Henson JM, Butler MJ, Day AW (1999) The dark side of the mycelium: Melanins of Phytopathogenic Fungi. Annu Rev Phytopathol 37:447–471

    Article  PubMed  CAS  Google Scholar 

  • Herrmann M, Zocher R, Haese A (1996) Effect of disruption of the enniatin synthetase gene on the virulence of Fusarium avenaceum. Mol Plant Microbe Interact 9:226–232

    Article  PubMed  CAS  Google Scholar 

  • Hirsch HM (1954) Environmental factors influencing the differentiation of protoperithecia and their relation to tyrosinase and melanin formation in Neurospora crassa. Physiologia Plantarum 7:72–97

    Article  CAS  Google Scholar 

  • Hoffmeister D, Keller NP (2007) Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24:393–416

    Article  PubMed  CAS  Google Scholar 

  • Hohn TM, Beremand PD (1989) Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. Gene 79:131–138

    Article  PubMed  CAS  Google Scholar 

  • Hohn TM, McCormick SP, Desjardins AE (1993) Evidence for a gene cluster involving trichothecene-pathway biosynthetic genes in Fusarium sporotrichioides. Curr Genet 24:291–295

    Article  PubMed  CAS  Google Scholar 

  • Horowitz NH, Charlang G, Horn G, Williams NP (1976) Isolation and identification of the conidial germination factor of Neurospora crassa. J Bacteriol 127:135–140

    PubMed  CAS  Google Scholar 

  • Howard RJ, Ferrari MA (1989) Role of melanin in appressorium formation. Exp Mycol 13:403–418

    Article  CAS  Google Scholar 

  • Howard RJ, Ferrari MA, Roach DH, Money NP (1991) Penetration of hard substrates by a fungus employing enormous turgor pressures. Proc Nat Acad Sci USA 88:11281–11284

    Article  PubMed  CAS  Google Scholar 

  • Howard RJ, Valent B (1996) Breaking and entering: host penetration by the fungal rice blast pathogen Magnaporthe grisea. Annu Rev Microbiol 50:491–512

    Article  PubMed  CAS  Google Scholar 

  • Inderbitzin P, Asvarak T, Turgeon BG (2010) Six new genes required for production of T-toxin, a polyketide determinant of high virulence of Cochliobolus heterostrophus to maize. Mol Plant Microbe Interact 23:458–472

    Article  PubMed  CAS  Google Scholar 

  • Jacobson ES (2000) Pathogenic roles for fungal melanins. Clin Microbiol Rev 13:708–717

    Article  PubMed  CAS  Google Scholar 

  • Jaenicke E, Decker H (2004) Functional changes in the family of type 3 copper proteins during evolution. Chembiochem 5:163–169

    Article  PubMed  CAS  Google Scholar 

  • Jahn B, Koch A, Schmidt A, Wanner G, Gehringer H, Bhakdi S, Brakhage AA (1997) Isolation and characterization of a pigmentless–conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence. Infect Immun 65:5110–5117

    PubMed  CAS  Google Scholar 

  • Jahn B, Langfelder K, Schneider U, Schindel C, Brakhage AA (2002) PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages. Cell Microbiol 4:793–803

    Article  PubMed  CAS  Google Scholar 

  • Johnson RD, Johnson L, Itoh Y, Kodama M, Otani H, Kohmoto K (2000) Cloning and characterization of a cyclic peptide synthetase gene from Alternaria alternata apple pathotype whose product is involved in AM-toxin synthesis and pathogenicity. Mol Plant Microbe Interact 13:742–753

    Article  PubMed  CAS  Google Scholar 

  • Kämper J, Kahmann R, Bölker M, Ma LJ, Brefort T, Saville BJ, Banuett F, Kronstad JW, Gold SE, Müller O, Perlin MH, Wösten HA, de V, R., Ruiz-Herrera J, Reynaga-Pena CG, Snetselaar K, McCann M, Pérez-Martin J, Feldbrügge M, Basse CW, Steinberg G, Ibeas JI, Holloman W, Guzman P, Farman M, Stajich JE, Sentandreu R, González-Prieto JM, Kennell JC, Molina L, Schirawski J, Mendoza-Mendoza A, Greilinger D, Münch K, Rössel N, Scherer M, Vranes M, Ladendorf O, Vincon V, Fuchs U, Sandrock B, Meng S, Ho EC, Cahill MJ, Boyce K, Klose J, Klosterman SJ, Deelstra HJ, Ortiz-Castellanos L, Li W, Sanchez-Alonso P, Schreier PH, Häuser-Hahn I, Vaupel M, Koopmann E, Friedrich G, Voss H, Schlüter T, Margolis J, Platt D, Swimmer C, Gnirke A, Chen F, Vysotskaia V, Mannhaupt G, Güldener U, Münsterkötter M, Haase D, Oesterheld M, Mewes HW, Mauceli EW, DeCaprio D, Wade CM, Butler J, Young S, Jaffe DB, Calvo S, Nusbaum C, Galagan J, Birren BW (2006) Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature 444:97–101

    Google Scholar 

  • Karkowska-Kuleta J, Rapala-Kozik M, Kozik A (2009) Fungi pathogenic to humans: molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. Acta Biochim Pol 56:211–224

    PubMed  CAS  Google Scholar 

  • Kawaide H, Imai R, Sassa T, Kamiya Y (1997) Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis. J Biol Chem 272:21706–21712

    Article  PubMed  CAS  Google Scholar 

  • Kawamura C, Moriwaki J, Kimura N, Fujita Y, Fuji S, Hirano T, Koizumi S, Tsuge T (1997) The melanin biosynthesis genes of Alternaria alternata can restore pathogenicity of the melanin-deficient mutants of Magnaporthe grisea. Mol Plant Microbe Interact 10:446–453

    Article  PubMed  CAS  Google Scholar 

  • Kawamura C, Tsujimoto T, Tsuge T (1999) Targeted disruption of a melanin biosynthesis gene affects conidial development and UV tolerance in the Japanese pear pathotype of Alternaria alternata. Mol Plant Microbe Interact 12:59–63

    Article  PubMed  CAS  Google Scholar 

  • Keller NP, Hohn TM (1997) Metabolic pathway gene clusters in filamentous fungi. Fungal Genet Biol 21:17–29

    Article  CAS  Google Scholar 

  • Keller NP, Turner G, Bennett JW (2005) Fungal secondary metabolism – from biochemistry to genomics. Nat Rev Microbiol 3:937–947

    Article  PubMed  CAS  Google Scholar 

  • Khaldi N, Collemare J, Lebrun M-H, Wolfe KH (2008) Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi. Genome Biol 9:R18

    Article  PubMed  CAS  Google Scholar 

  • Khaldi N, Wolfe KH (2008) Elusive origins of the extra genes in Aspergillus oryzae. PLOS One 3:e3036

    Article  PubMed  CAS  Google Scholar 

  • Kihara J, Moriwaki A, Ito M, Arase S, Honda Y (2004) Expression of THR1, a 1,3,8-trihydroxynaphthalene reductase gene involved in melanin biosynthesis in the phytopathogenic fungus Bipolaris oryzae, is enhanced by near-ultraviolet radiation. Pigment Cell Res 17:15–23

    Article  PubMed  CAS  Google Scholar 

  • Kim KH, Cho Y, La Rota M, Cramer Jr. RA, Lawrence CB (2007) Functional analysis of the Alternaria brassicicola non–ribosomal peptide synthetase gene AbNPS2 reveals a role in conidial cell wall construction. Mol Plant Pathol 8:23–39

    Article  PubMed  CAS  Google Scholar 

  • Kimura M, Tokai T, O'Donnell K, Ward TJ, Fujimura M, Hamamoto H, Shibata T, Yamaguchi I (2003) The trichothecene biosynthesis gene cluster of Fusarium graminearum F15 contains a limited number of essential pathway genes and expressed non-essential genes. FEBS Lett 539:105–110

    Article  PubMed  CAS  Google Scholar 

  • Kimura M, Tokai T, Takahashi-Ando N, Ohsato S, Fujimura M (2007) Molecular and genetic studies of Fusarium trichothecene biosynthesis: pathways, genes, and evolution. Biosci Biotechnol Biochem 71:2105–2123

    Article  PubMed  CAS  Google Scholar 

  • Kimura N, Tsuge T (1993) Gene cluster involved in melanin biosynthesis of the filamentous fungus Alternaria alternata. J Bacteriol 175:4427–4435

    PubMed  CAS  Google Scholar 

  • Kodama M, Rose MS, Yang G, Yun SH, Yoder OC, Turgeon BG (1999) The translocation-associated tox1 locus of Cochliobolus heterostrophus is two genetic elements on two different chromosomes. Genetics 151:585–596

    PubMed  CAS  Google Scholar 

  • Kono Y, Takeuchi S, Kawarada A, Daly JM, Knoche HW (1980) Studies on the host-specific pathotoxins produced by Helminthosporium maydis, race T. Agric Biol Chem 44:2613–2622

    Article  CAS  Google Scholar 

  • Koschorreck K, Schmid RD, Urlacher VB (2009) Improving the functional expression of a Bacillus licheniformis laccase by random and site-directed mutagenesis. BMC Biotechnol 9:12

    Article  PubMed  CAS  Google Scholar 

  • Kroken S, Glass NL, Taylor JW, Yoder OC, Turgeon BG (2003) Phylogenomic analyis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes. Proc Nat Acad Sci USA 100:15670–15675

    Article  PubMed  CAS  Google Scholar 

  • Kubo Y, Suzuki K, Furusawa I, Ishida N, Yamamoto M (1982) Relation of appressorium pigmentation and penetration of nitrocellulose membranes by Colletotrichum lagenarium. Phytopathol 72:498–501

    Article  CAS  Google Scholar 

  • Kubo Y, Nakamura H, Kobayashi K, Okuno T, Furusawa I (1991) Cloning of a melanin biosynthetic gene essential for appressorial penetration of Colletotrichum lagenarium. Mol Plant Microbe Interact 4:440–445

    Article  CAS  Google Scholar 

  • Kubo Y, Takano Y, Endo N, Yasuda N, Tajima S, Furusawa I (1996) Cloning and structural analysis of the melanin biosynthesis gene SCD1 encoding scytalone dehydratase in Colletotrichum lagenarium. Appl Environ Microbiol 62:4340–4344

    PubMed  CAS  Google Scholar 

  • Landan G, Cohen G, Aharonowitz Y, Shuali Y, Graur D, Shiffman D (1990) Evolution of isopenicillin N synthase genes may have involved horizontal gene transfer. Mol Biol Evol 7:399–406

    PubMed  CAS  Google Scholar 

  • Langfelder K, Jahn B, Gehringer H, Schmidt A, Wanner G, Brakhage AA (1998) Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence. Med Microbiol Immunol 187:79–89

    Article  PubMed  CAS  Google Scholar 

  • Langfelder K, Streibel M, Jahn B, Haase G, Brakhage AA (2003) Biosynthesis of fungal melanins and their importance for human pathogenic fungi. Fungal Genet Biol 38:143–158

    Article  PubMed  CAS  Google Scholar 

  • Lee BN, Kroken S, Chou DYT, Robbertse B, Yoder OC, Turgeon BG (2005) Functional analysis of all nonribosomal peptide synthetases in Cochliobolus heterostrophus reveals a factor, NPS6, involved in virulence and resistance to oxidative stress. Eukaryot Cell 4:545–555

    Article  PubMed  CAS  Google Scholar 

  • Liu GY, Nizet V (2009) Color me bad: microbial pigments as virulence factors. Trends Microbiol 17:406–413

    Article  PubMed  CAS  Google Scholar 

  • Lorenz N, Haarmann T, Pazoutová S, Jung M, Tudzynski P (2009) The ergot alkaloid gene cluster: Functional analyses and evolutionary aspects. Phytochemistry 70:1822–1832

    Article  PubMed  CAS  Google Scholar 

  • Machida M, Asai K, Sano M, Tanaka T, Kumagai T, Terai G, Kusumoto K-I, Arima T, Akita O, Kashiwagi Y, Abe K, Gomi K, Horiuchi H, Kitamoto K, Kobayashi T, Takeuchi M, Denning DW, Galagan JE, Nierman WC, Yu J, Archer DB, Bennett JW, Bhatnagar D, Cleveland TE, Fedorova ND, Gotoh O, Horikawa H, Hosoyama A, Ichinomiya M, Igarashi R, Iwashita K, Juvvadi PR, Kato M, Kato Y, Kin T, Kokubun A, Maeda H, Maeyama N, Maruyama J-i, Nagasaki H, Nakajima T, Oda K, Okada K, Paulsen I, Sakamoto K, Sawano T, Takahashi M, Takase K, Terabayashi Y, Wortman JR, Yamada O, Yamagata Y, Anazawa H, Hata Y, Koide Y, Komori T, Koyama Y, Minetoki T, Suharnan S, Tanaka A, Isono K, Kuhara S, Ogasawara N, Kikuchi H (2005) Genome sequencing and analysis of Aspergillus oryzae. Nature 438:1157–1161

    Article  PubMed  Google Scholar 

  • Martin F, Aerts A, Ahren D, Brun A, Danchin EGJ, Duchaussoy F, Gibon J, Kohler A, Lindquist E, Pereda V, Salamov A, Shapiro HJ, Wuyts J, Blaudez D, Buee M, Brokstein P, Canback B, Cohen D, Courty PE, Coutinho PM, Delaruelle C, Detter JC, Deveau A, DiFazio S, Duplessis S, Fraissinet-Tachet L, Lucic E, Frey-Klett P, Fourrey C, Feussner I, Gay G, Grimwood J, Hoegger PJ, Jain P, Kilaru S, Labbe J, Lin YC, Legue V, Le Tacon F, Marmeisse R, Melayah D, Montanini B, Muratet M, Nehls U, Niculita-Hirzel H, Secq MPO-L, Peter M, Quesneville H, Rajashekar B, Reich M, Rouhier N, Schmutz J, Yin T, Chalot M, Henrissat B, Kues U, Lucas S, Van de Peer Y, Podila GK, Polle A, Pukkila PJ, Richardson PM, Rouze P, Sanders IR, Stajich JE, Tunlid A, Tuskan G, Grigoriev IV (2008) The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis. Nature 452:88–92

    Article  PubMed  CAS  Google Scholar 

  • Martin F, Kohler A, Murat C, Balestrini R, Coutinho PM, Jaillon O, Montanini B, Morin E, Noel B, Percudani R, Porcel B, Rubini A, Amicucci A, Amselem J, Anthouard V, Arcioni S, Artiguenave F, Aury J-M, Ballario P, Bolchi A, Brenna A, Brun A, Buee M, Cantarel B, Chevalier G, Couloux A, Da Silva C, Denoeud F, Duplessis S, Ghignone S, Hilselberger B, Iotti M, Marcais B, Mello A, Miranda M, Pacioni G, Quesneville H, Riccioni C, Ruotolo R, Splivallo R, Stocchi V, Tisserant E, Viscomi AR, Zambonelli A, Zampieri E, Henrissat B, Lebrun M-H, Paolocci F, Bonfante P, Ottonello S, Wincker P (2010) Périgord black truffle genome uncovers evolutionary origins and mechanisms of symbiosis. Nature 464:1033–1039

    Article  PubMed  CAS  Google Scholar 

  • Martinez D, Challacombe J, Morgenstern I, Hibbett D, Schmoll M, Kubicek CP, Ferreira P, Ruiz-Duenas FJ, Martinez AT, Kersten P, Hammel KE, Vanden Wymelenberg A, Gaskell J, Lindquist E, Sabat G, Splinter BonDurant S, Larrondo LF, Canessa P, Vicuna R, Yadav J, Doddapaneni H, Subramanian V, Pisabarro AG, LavÃn JL, Oguiza JA, Master E, Henrissat B, Coutinho PM, Harris P, Magnuson JK, Baker SE, Bruno K, Kenealy W, Hoegger PJ, Kües U, Ramaiya P, Lucas S, Salamov A, Shapiro H, Tu H, Chee CL, Misra M, Xie G, Teter S, Yaver D, James T, Mokrejs M, Pospisek M, Grigoriev IV, Brettin T, Rokhsar D, Berka R, Cullen D (2009) Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion. Proc Nat Acad Sci USA 106:1954–1959

    Article  PubMed  CAS  Google Scholar 

  • Matzanke BF, Bill E, Trautwein AX, Winkelmann G (1987) Role of siderophores in iron storage in spores of Neurospora crassa and Aspergillus ochraceus. J Bacteriol 169:5873–5876

    PubMed  CAS  Google Scholar 

  • Mendgen K, Hahn M, Deising H (1996) Morphogenesis and mechanisms of penetration by plant pathogenic fungi. Annu Rev Phytopathol 34:367–386

    Article  PubMed  CAS  Google Scholar 

  • Metzger U, Schall C, Zocher G, Unsöld I, Stec E, Li S-M, Heide L, Stehle T (2009) The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proc Nat Acad Sci USA 106:14309–14314

    Article  PubMed  CAS  Google Scholar 

  • Mironenko NV, Alekhina IA, Zhdanova NN, Bulat SA (2000) Intraspecific variation in gamma-radiation resistance and genomic structure in the filamentous fungus Alternaria alternata: a case study of strains inhabiting Chernobyl reactor no. 4. Ecotoxicol Environ Saf 45:177–187

    Article  PubMed  CAS  Google Scholar 

  • Misiek M, Hoffmeister D (2007) Fungal genetics, genomics, and secondary metabolites in pharmaceutical sciences. Planta Med 73:103–115

    Article  PubMed  CAS  Google Scholar 

  • Money NP, Howard RJ (1996) Confirmation of a link between fungal pigmentation, turgor pressure, and pathogenicity using a new method of turgor measurement. Fungal Genet Biol 20:217–227

    Article  Google Scholar 

  • Morris-Jones R, Youngchim S, Hextall JM, Gomez BL, Morris-Jones SD, Hay RJ, Casadevall A, Nosanchuk JD, Hamilton AJ (2004) Scytalidium dimidiatum causing recalcitrant subcutaneous lesions produces melanin. J Clin Microbiol 42:3789–3794

    Article  PubMed  CAS  Google Scholar 

  • Morris-Jones R, Gomez BL, Diez S, Uran M, Morris-Jones SD, Casadevall A, Nosanchuk JD, Hamilton AJ (2005) Synthesis of melanin pigment by Candida albicans in vitro and during infection. Infect Immun 73:6147–6150

    Article  PubMed  CAS  Google Scholar 

  • Motoyama T, Imanishi K, Yamaguchi I (1998) cDNA cloning, expression, and mutagenesis of scytalone dehydratase needed for pathogenicity of the rice blast fungus, Pyricularia oryzae. Biosci Biotechnol Biochem 62:564–566

    Article  PubMed  CAS  Google Scholar 

  • Nicholson MJ, Koulman A, Monahan BJ, Pritchard BL, Payne GA, Scott B (2009) Identification of two aflatrem biosynthesis gene loci in Aspergillus flavus and metabolic engineering of Penicillium paxilli to elucidate their function. Appl Env Microbiol 75:7469–7481

    Article  CAS  Google Scholar 

  • Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB, Bermejo C, Bennett J, Bowyer P, Chen D, Collins M, Coulsen R, Davies R, Dyer PS, Farman M, Fedorova N, Fedorova N, Feldblyum TV, Fischer R, Fosker N, Fraser A, Garcia JL, Garcia MJ, Goble A, Goldman GH, Gomi K, Griffith-Jones S, Gwilliam R, Haas B, Haas H, Harris D, Horiuchi H, Huang J, Humphray S, Jimenez J, Keller N, Khouri H, Kitamoto K, Kobayashi T, Konzack S, Kulkarni R, Kumagai T, Lafton A, Latge J-P, Li W, Lord A, Lu C, Majoros WH, May GS, Miller BL, Mohamoud Y, Molina M, Monod M, Mouyna I, Mulligan S, Murphy L, O'Neil S, Paulsen I, Penalva MA, Pertea M, Price C, Pritchard BL, Quail MA, Rabbinowitsch E, Rawlins N, Rajandream M-A, Reichard U, Renauld H, Robson GD, de Cordoba SR, Rodriguez-Pena JM, Ronning CM, Rutter S, Salzberg SL, Sanchez M, Sanchez-Ferrero JC, Saunders D, Seeger K, Squares R, Squares S, Takeuchi M, Tekaia F, Turner G, de Aldana CRV, Weidman J, White O, Woodward J, Yu J-H, Fraser C, Galagan JE, Asai K, Machida M, Hall N, Barrell B, Denning DW (2005) Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438:1151–1156

    Article  PubMed  CAS  Google Scholar 

  • Nosanchuk JD, Gomez BL, Youngchim S, Diez S, Aisen P, Zancope-Oliveira RM, Restrepo A, Casadevall A, Hamilton AJ (2002) Histoplasma capsulatum synthesizes melanin-like pigments in vitro and during mammalian infection. Infect Immun 70:5124–5131

    Article  PubMed  CAS  Google Scholar 

  • Nosanchuk JD, Casadevall A (2003) The contribution of melanin to microbial pathogenesis. Cell Microbiol 5:203–223

    Article  PubMed  CAS  Google Scholar 

  • Nosanchuk JD, van Duin D, Mandal P, Aisen P, Legendre AM, Casadevall A (2004) Blastomyces dermatitidis produces melanin in vitro and during infection. FEMS Microbiol Lett 239:187–193

    Article  PubMed  CAS  Google Scholar 

  • Nosanchuk JD, Casadevall A (2006) Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds. Antimicrob Agents Chemother 50:3519–3528

    Article  PubMed  CAS  Google Scholar 

  • Nosanchuk JD, Yu JJ, Hung CY, Casadevall A, Cole GT (2007) Coccidioides posadasii produces melanin in vitro and during infection. Fungal Genet Biol 44:517–520

    Article  PubMed  CAS  Google Scholar 

  • Nowrousian M (2009) A novel polyketide biosynthesis gene cluster is involved in fruiting body morphogenesis in the filamentous fungi Sordaria macrospora and Neurospora crassa. Curr Genet 55:185–198

    Article  PubMed  CAS  Google Scholar 

  • Nowrousian M, Stajich JE, Chu M, Engh I, Espagne E, Halliday K, Kamerewerd J, Kempken F, Knab B, Kuo HC, Osiewacz HD, Pöggeler S, Read ND, Seiler S, Smith KM, Zickler D, Kück U, Freitag M (2010) De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis. PLoS Genet 6:e1000891

    Article  PubMed  CAS  Google Scholar 

  • Oide S, Moeder W, Krasnoff S, Gibson D, Haas H, Yoshioka K, Turgeon BG (2006) NPS6, encoding a nonribosomal peptide synthetase involved in siderophore-mediated iron metabolism, is a conserved virulence determinant of plant pathogenic ascomycetes. Plant Cell 18:2836–2853

    Article  PubMed  CAS  Google Scholar 

  • Oide S, Krasnoff SB, Gibson DM, Turgeon BG (2007) Intracellular siderophores are essential for ascomycete sexual development in heterothallic Cochliobolus heterostrophus and homothallic Gibberella zeae. Eukaryot Cell 6:1339–1353

    Article  PubMed  CAS  Google Scholar 

  • Ozeki H, Ito S, Wakamatsu K, Ishiguro I (1997a) Chemical characterization of pheomelanogenesis starting from dihydroxyphenylalanine or tyrosine and cysteine. Effects of tyrosinase and cysteine concentrations and reaction time. Biochim Biophys Acta 1336:539–548

    CAS  Google Scholar 

  • Ozeki H, Wakamatsu K, Ito S, Ishiguro I (1997b) Chemical characterization of eumelanins with special emphasis on 5,6-dihydroxyindole-2-carboxylic acid content and molecular size. Anal Biochem 248:149–157

    Article  PubMed  CAS  Google Scholar 

  • Panaccione DG, Scott-Craig JS, Pocard JA, Walton JD (1992) A cyclic peptide synthetase gene required for pathogenicity of the fungus Cochliobolus carbonum on maize. Proc Nat Acad Sci USA 89:6590–6594

    Article  PubMed  CAS  Google Scholar 

  • Panaccione DG, Johnson RD, Wang J, Young CA, Damrongkool P, Scott B, Schardl CL (2001) Elimination of ergovaline from a grass–Neotyphodium endophyte symbiosis by genetic modification of the endophyte. Proc Nat Acad Sci USA 98:12820–12825

    Article  PubMed  CAS  Google Scholar 

  • Patron NJ, Waller RF, Cozijnsen AJ, Straney DC, Gardiner DM, Nierman WC, Howlett BJ (2007) Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes. BMC Evol Biol 7:174

    Article  PubMed  CAS  Google Scholar 

  • Pel HJ, de Winde JH, Archer DB, Dyer PS, Hofmann G, Schaap PJ, Turner G, de Vries RP, Albang R, Albermann K, Andersen MR, Bendtsen JD, Benen JAE, van den Berg M, Breestraat S, Caddick MX, Contreras R, Cornell M, Coutinho PM, Danchin EGJ, Debets AJM, Dekker P, van Dijck PWM, van Dijk A, Dijkhuizen L, Driessen AJM, d'Enfert C, Geysens S, Goosen C, Groot GSP, de Groot PWJ, Guillemette T, Henrissat B, Herweijer M, van den Hombergh JPTW, van den Hondel CAMJJ, van der Heijden RTJM, van der Kaaij RM, Klis FM, Kools HJ, Kubicek CP, van Kuyk PA, Lauber J, Lu X, van der Maarel MJEC, Meulenberg R, Menke H, Mortimer MA, Nielsen J, Oliver SG, Olsthoorn M, Pal K, van Peij NNME, Ram AFJ, Rinas U, Roubos JA, Sagt CMJ, Schmoll M, Sun J, Ussery D, Varga J, Vervecken W, van de Vondervoort PJJ, Wedler H, Wosten HAB, Zeng A-P, van Ooyen AJJ, Visser J, Stam H (2007) Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat Biotech 25:221–231

    Article  Google Scholar 

  • Penalva MA, Moya A, Dopazo J, Ramón D (1990) Sequences of isopenicillin N synthetase genes suggest horizontal gene transfer from prokaryotes to eukaryotes. Proc Biol Sci 241:164–169

    Article  PubMed  CAS  Google Scholar 

  • Perpetua NS, Kubo Y, Takano Y, Furusawa I (1996) Cloning and characterization of a melanin biosynthetic THR1 reductase gene essential for appressorial penetration of Colletotrichum lagenarium. Mol Plant Microbe Interact 9:323–329

    Article  PubMed  CAS  Google Scholar 

  • Perrin RM, Fedorova ND, Bok JW, Cramer RA, Wortman JR, Kim HS, Nierman WC, Keller NP (2007) Transcriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA. PLoS Pathog 3:e50

    Article  PubMed  CAS  Google Scholar 

  • Pihet M, Vandeputte P, Tronchin G, Renier G, Saulnier P, Georgeault S, Mallet R, Chabasse D, Symoens F, Bouchara JP (2009) Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia. BMB Microbiol 9:177

    Article  CAS  Google Scholar 

  • Polacheck I, Kwon-Chung KJ (1988) Melanogenesis in Cryptococcus neoformans. J Gen Microbiol 134:1037–1041

    PubMed  CAS  Google Scholar 

  • Prade RA, Cruz AK, Terenzi HF (1984) Regulation of tyrosinase during the vegetative and sexual life-cycles of Neurospora crassa. Archives of Microbiology 140:236–242

    Article  CAS  Google Scholar 

  • Proctor RH, Hohn TM, McCormick SP (1995) Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene. Mol Plant Microbe Interact 8:593–601

    Article  PubMed  CAS  Google Scholar 

  • Proctor RH, McCormick SP, Alexander NJ, Desjardins AE (2009) Evidence that a secondary metabolic biosynthetic gene cluster has grown by gene relocation during evolution of the filamentous fungus Fusarium. Mol Microbiol 74:1128–1142

    Article  PubMed  CAS  Google Scholar 

  • Ragnelli AM, Pacioni G, Aimola P, Lanza B, Miranda M (1992) Truffle melanogenesis: correlation with reproductive differentiation and ascocarp ripening. Pigment Cell Research 5:205–212

    Article  PubMed  CAS  Google Scholar 

  • Ranocha P, Chabannes M, Chamayou S, Danoun S, Jauneau A, Boudet AM, Goffner D (2002) Laccase down-regulation causes alterations in phenolic metabolism and cell wall structure in poplar. Plant Physiol 129:145–155

    Article  PubMed  CAS  Google Scholar 

  • Reverberi M, Ricelli A, Zjalic S, Fabbri AA, Fanelli C (2010) Natural functions of mycotoxins and control of their biosynthesis in fungi. Appl Microbiol Biotechnol 87:899–911

    Article  PubMed  CAS  Google Scholar 

  • Reyes-Dominguez Y, Bok JW, Berger H, Shwab EK, Basheer A, Gallmetzer A, Scazzocchio C, Keller N, Strauss J (2010) Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans. Mol Microbiol in press:

    Google Scholar 

  • Riley PA (1997) Melanin. Int J Biochem Cell Biol 29:1235–1239

    Article  PubMed  CAS  Google Scholar 

  • Rohlfs M, Albert M, Keller NP, Kempken F (2007) Secondary chemicals protect mould from fungivory. Biol Lett 3:523–525

    Article  PubMed  Google Scholar 

  • Romero-Martinez R, Wheeler M, Guerrero-Plata A, Rico G, Torres-Guerrero H (2000) Biosynthesis and functions of melanin in Sporothrix schenckii. Infect Immun 68:3696–3703

    Article  PubMed  CAS  Google Scholar 

  • Rose MS, Yun S-H, Asvarak T, Lu S-W, Yoder OC, Turgeon BG (2002) A decarboxylase encoded at the Cochliobolus heterostrophus translocation-associated Tox1B locus is required for polyketide (T-toxin) biosynthesis and high virulence on T-cytoplasm maize. Mol Plant Microbe Interact 15:883–893

    Article  PubMed  CAS  Google Scholar 

  • Rosewich UL, Kistler HC (2000) Role of horizontal gene transfer in the evolution of fungi. Annu Rev Phytopathol 38:326–363

    Article  Google Scholar 

  • Saika S, Nicholson MJ, Young C, Parker EJ, Scott B (2008) The genetic basis for indole-diterpene chemical diversity in filamentous fungi. Mycol Res 112:184–199

    Article  CAS  Google Scholar 

  • Saikia S, Parker EJ, Koulman A, Scott B (2006) Four gene products are required for the fungal synthesis of the indole-diterpene, paspaline. FEBS Lett 580:1625–1630

    Article  PubMed  CAS  Google Scholar 

  • Sanchez-Ferrer A, Rodriguez-Lopez JN, Garcia-Canovas F, Garcia-Carmona F (1995) Tyrosinase: a comprehensive review of its mechanism. Biochim Biophys Acta 1247:1–11

    Article  PubMed  Google Scholar 

  • Sandmann G (1994) Carotenoid biosynthesis in microorganisms and plants. Eur J Biochem 223:7–24

    Article  PubMed  CAS  Google Scholar 

  • Schardl CL (2001) Epichloë festucae and related mutualistic symbionts of grasses. Fungal Genet Biol 33:69–82

    Article  PubMed  CAS  Google Scholar 

  • Schardl CL, Panaccione DG, Tudzynski P (2006) Ergot alkaloids – biology and molecular biology. Alkaloids Chem Biol 63:45–86

    Article  PubMed  CAS  Google Scholar 

  • Schimek C, Wöstermeyer J (2009) Carotene derivatives in sexual communictaion of zygomycete fungi. Phytochemistry 70:1867–1875

    Article  PubMed  CAS  Google Scholar 

  • Schrettl M, Winkelmann G, Haas H (2004) Ferrichrome in Schizosaccharomyces pombe – an iron transport and iron storage compound. Biometals 17:647–654

    Article  PubMed  CAS  Google Scholar 

  • Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst HN, Jr., Haynes K, Haas H (2007) Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog 3:e128

    Article  CAS  Google Scholar 

  • Seshime Y, Juvvadi PR, Fujii I, Kitamoto K (2005) Discovery of a novel superfamily of type III polyketide synthases in Aspergillus oryzae. Biochem Biophys Res Commun 331:253–260

    Article  PubMed  CAS  Google Scholar 

  • Shaaban M, Palmer JM, El-Naggar WA, El-Sokkary MA, Habib ELSE, Keller NP (2010) Involvement of transposon-like elements in penicillin gene cluster regulation. Fungal Genet Biol 47:423–432

    Article  PubMed  CAS  Google Scholar 

  • Shwab EK, Bok JW, Tribus M, Galehr J, Graessle S, Keller NP (2007) Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot Cell 6:1656–1664

    Article  PubMed  CAS  Google Scholar 

  • Singaravelan N, Grishkan I, Beharav A, Wakamatsu K, Ito S, Nevo E (2008) Adaptive melanin response of the soil fungus Aspergillus niger to UV radiation stress at “Evolution Canyon”, Mount Carmel, Israel. PLoS One 3:e2993

    Article  CAS  Google Scholar 

  • Soler-Rivas C, Jolivet S, Arpin N, Olivier JM, Wichers HJ (1999) Biochemical and physiological aspects of brown blotch disease of Agaricus bisporus. FEMS Microbiol Rev 23:591–614

    Article  PubMed  CAS  Google Scholar 

  • Song Z, Cox RJ, Lazarus CM, Simpson TJ (2004) Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum. Chembiochem 5:1196–1203

    Article  PubMed  CAS  Google Scholar 

  • Spiering MJ, Moon CD, Wilkinson HH, Schardl CL (2005) Gene clusters for insecticidal loline alkaloids in the grass-endophytic fungus Neotyphodium uncinatum. Genetics 169:1403–1414

    Article  PubMed  CAS  Google Scholar 

  • Starratt AN, Ross LM, Lazarovits G (2002) 1,8-Dihydroxynaphthalene monoglucoside, a new metabolite of Sclerotinia sclerotiorum, and the effect of tricyclazole on its production. Can J Microbiol 48:320–325

    Article  PubMed  CAS  Google Scholar 

  • Staunton J, Weissman KJ (2001) Polyketide biosynthesis: a millenium review. Nat Prod Rep 18:380–416

    Article  PubMed  CAS  Google Scholar 

  • Steffan N, Grundmann A, Yin WB, Kremer A, Li SM (2009) Indole prenyltransferases from fungi: a new enzyme group with high potential for the production of prenylated indole derivatives. Curr Med Chem 16:218–231

    Article  PubMed  CAS  Google Scholar 

  • Stipanovic RD, Bell AA (1976) Pentaketide metabolites of Verticillium dahliae. 3. Identification of (−−)-3,4-dihydro-3,8-dihydroxy-1(2h)-naphtalenone[(−−)-vermelone] as a precursor to melanin. J Org Chem 41:2468–2469

    Article  PubMed  CAS  Google Scholar 

  • Sturley SL (2000) Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast. Biochim Biophys Acta 1529:155–163

    Article  PubMed  CAS  Google Scholar 

  • Stüssi H, Rast DM (1981) The biosynthesis and possible function of gamma-glutaminyl-4-hydroxybenzene in Agaricus bisporus. Phytochemistry 20:2347–2352

    Article  Google Scholar 

  • Sugareva V, Hartl A, Brock M, Hubner K, Rohde M, Heinekamp T, Brakhage AA (2006) Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus. Arch Microbiol 186:345–355

    Article  PubMed  CAS  Google Scholar 

  • Suryanarayanan TS, Ravishankar JP, Venkatesan G, Murali TS (2004) Characterization of the melanin pigment of a cosmopolitan fungal endophyte. Mycol Res 108:974–978

    Article  PubMed  CAS  Google Scholar 

  • Taborda CP, da Silva MB, Nosanchuk JD, Travassos LR (2008) Melanin as a virulence factor of Paracoccidioides brasiliensis and other dimorphic pathogenic fungi: a minireview. Mycopathologia 165:331–339

    Article  PubMed  CAS  Google Scholar 

  • Takano Y, Kubo Y, Shimizu K, Mise K, Okuno T, Furusawa I (1995) Structural analysis of PKS1, a polyketide synthase gene involved in melanin biosynthesis in Colletotrichum lagenarium. Mol Gen Genet 249:162–167

    Article  PubMed  CAS  Google Scholar 

  • Takano Y, Kubo Y, Kawamura C, Tsuge T, Furusawa I (1997) The Alternaria alternata melanin biosynthesis gene restores appressorial melanization and penetration of cellulose membranes in the melanin-deficient albino mutant of Colletotrichum lagenarium. Fungal Genet Biol 21:131–140

    Article  CAS  Google Scholar 

  • Tanabe K, Nishimura S, Kohmoto K (1988) Pathogenicity of pectic enzymes and melanin-deficient mutants of Alternaria alternata Japanese pear pathotype. Ann Phytopath Soc Jpn 54:364

    Google Scholar 

  • Tanaka A, Tapper BA, Popay A, Parker EJ, Scott B (2005) A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory. Mol Microbiol 57:1036–1050

    Article  PubMed  CAS  Google Scholar 

  • Tanguay P, Bozza S, Breuil C (2006) Assessing RNAi frequency and efficiency in Ophiostoma floccosum and O. piceae. Fungal Genet Biol 43:804–812

    Article  PubMed  CAS  Google Scholar 

  • Taylor BE, Wheeler MH, Szaniszlo PJ (1987) Evidence for pentaketide melanin biosynthesis in dematiaceous human pathogenic fungi. Mycologia 79:320–322

    Article  CAS  Google Scholar 

  • Thompson JE, Fahnestock S, Farrall L, Liao DI, Valent B, Jordan DB (2000) The second naphthol reductase of fungal melanin biosynthesis in Magnaporthe grisea – Tetrahydroxynaphthalene reductase. J Biol Chem 275:34867–34872

    Article  PubMed  CAS  Google Scholar 

  • Thurston CF (1994) The structure and function of fungal laccases. Microbiology 140:19–26

    Article  CAS  Google Scholar 

  • Tokousbalides MC, Sisler HD (1979) Site of inhibition by tricyclazole in the melanin biosynthetic pathway of Verticillium dahliae. Pest Biochem Phys 11:64–73

    Article  CAS  Google Scholar 

  • Tsai HF, Wang H, Gebler JC, Poulter CD, Schardl CL (1995) The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the commited step for ergot alkaloid biosynthesis. Biochem Biophys Res Commun 216:119–125

    Article  PubMed  CAS  Google Scholar 

  • Tsai HF, Chang YC, Washburn RG, Wheeler MH, Kwon-Chung KJ (1998) The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence. J Bacteriol 180:3031–3038

    PubMed  CAS  Google Scholar 

  • Tsai HF, Wheeler MH, Chang YC, Kwon-Chung KJ (1999) A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus. J Bacteriol 181:6469–6477

    PubMed  CAS  Google Scholar 

  • Tsai HF, Fujii I, Watanabe A, Wheeler MH, Chang YC, Yasuoka Y, Ebizuka Y, Kwon-Chung KJ (2001) Pentaketide melanin biosynthesis in Aspergillus fumigatus requires chain-length shortening of a heptaketide precursor. J Biol Chem 276:29292–29298

    Article  PubMed  CAS  Google Scholar 

  • Tudzynski B, Hölter K (1998) Gibberellin biosynthetic pathway in Gibberella fujikuroi: evidence for a gene cluster. Fungal Genet Biol 25:157–170

    Article  PubMed  CAS  Google Scholar 

  • Tudzynski B, Kawaide H, Kamiya Y (1998) Gibberellin biosynthesis in Gibberella fujikuroi: cloning and characterization of the copalyl diphosphate synthase gene. Curr Genet 34:234–240

    Article  PubMed  CAS  Google Scholar 

  • Tudzynski B (2005) Gibberellin biosynthesis in fungi: genes, enzymes, evolution and impact on biotechnology. Appl Microbiol Biotechnol 66:597–611

    Article  PubMed  CAS  Google Scholar 

  • Tudzynski P, Hölter K, Correira T, Arntz C, Grammel N, Keller U (1999) Evidence for an ergot alkaloid gene cluster in Claviceps purpurea. Mol Gen Genet 261:133–141

    Article  PubMed  CAS  Google Scholar 

  • Unsöld IA, Li S-M (2005) Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus. Microbiology 151:1499–1505

    Article  PubMed  CAS  Google Scholar 

  • Uthandi S, Saad B, Humbard MA, Maupin-Furlow JA (2010) LccA, an archaeal laccase secreted as a highly stable glycoprotein into the extracellular medium by Haloferax volcanii. Appl Environ Microbiol 76:733–743

    Article  PubMed  CAS  Google Scholar 

  • van den Berg MA, Albang R, Albermann K, Badger JH, Daran J-M, M Driessen AJ, Garcia-Estrada C, Fedorova ND, Harris DM, Heijne WHM, Joardar V, W Kiel JAK, Kovalchuk A, Martin JF, Nierman WC, Nijland JG, Pronk JT, Roubos JA, van der Klei IJ, van Peij NNME, Veenhuis M, von Dohren H, Wagner C, Wortman J, Bovenberg RAL (2008) Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum. Nat Biotech 26:1161–1168

    Google Scholar 

  • van der Does HC, Rep M (2007) Virulence genes and the evolution of host specificity in plant-pathogenic fungi. Mol Plant Microbe Interact 20:1175–1182

    Article  PubMed  CAS  Google Scholar 

  • Velasco AM, Leguina JI, Laczcano A (2002) Molecular evolution of the lysine biosynthetic pathways. J Mol Evol 55:445–459

    Article  PubMed  CAS  Google Scholar 

  • Vershinin A (1999) Biological functions of carotenoids – diversity and evolution. Biofactors 10:99–104

    Article  PubMed  CAS  Google Scholar 

  • Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M (1994) Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing. Eur J Biochem 219:985–992

    Article  PubMed  CAS  Google Scholar 

  • Vining LC (1990) Functions of secondary metabolites. Annu Rev Microbiol 44:395–427

    Article  PubMed  CAS  Google Scholar 

  • Walton JD (2000) Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: an hypothesis. Fungal Genet Biol 30:167–171

    Article  PubMed  CAS  Google Scholar 

  • Wang YL, Aisen P, Casadevall A (1996) Melanin, melanin “ghosts,” and melanin composition in Cryptococcus neoformans. Infect Immun 64:2420–2424

    PubMed  CAS  Google Scholar 

  • Wapinski I, Pfeffer A, Friedman N, Regev A (2007) Natural history and evolutionary principles of gene duplication in fungi. Nature 449:54–61

    Article  PubMed  CAS  Google Scholar 

  • Wheeler MH, Tolmsoff WJ, Bell AA, Mollenhauer HH (1978) Ultrastructural and chemical distinction of melanins formed by Verticillium dahliae from (+)-scytalone,1,8-dihydroxynaphthalene, catechol, and L-3,4-dihydroxyphenylalanine. Can J Microbiol 24:289–297

    Article  PubMed  CAS  Google Scholar 

  • Wheeler MH (1983) Comparisons of fungal melanin biosynthesis in ascomycetous, imperfect and basidiomycetous fungi. Trans Br Mycol Soc 81:29–36

    Article  CAS  Google Scholar 

  • Wheeler MH, Bell AA (1988) Melanins and their importance in pathogenic fungi. Curr Top Med Mycol 2:338–387

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson HH, Siegel MR, Blankenship JD, Mallory AC, Bush LP, Schardl C (2000) Contribution of fungal loline alkaloids to protection from aphids in a grass-endophyte mutualism. Mol Plant Microbe Interact 13:1027–1033

    Article  PubMed  CAS  Google Scholar 

  • Williamson PR, Wakamatsu K, Ito S (1998) Melanin biosynthesis in Cryptococcus neoformans. J Bacteriol 180:1570–1572

    PubMed  CAS  Google Scholar 

  • Wolf JC, Mirocha CJ (1973) Regulation of sexual reproduction in Gibberella zeae (Fusarium roseum “Graminearum”) by F-2 (Zearalenone). Can J Microbiol 19:725–734

    Article  PubMed  CAS  Google Scholar 

  • Woloshuk CP, Foutz KR, Brewer JF, Bhatnagar D, Cleveland TE, Payne GA (1994) Molecular characterization of aflR, a regulatory locus for aflatoxin biosynthesis. Appl Env Microbiol 60:2408–2414

    CAS  Google Scholar 

  • Woo PCY, Tam EWT, Chong KTK, Cai JJ, Tung ETK, Ngan AHY, Lau SKP, Yuen KY (2010) High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei. FEBS J 277:3750–3758

    Article  PubMed  CAS  Google Scholar 

  • Xu J, Saunders CW, Hu P, Grant RA, Boekhout T, Kuramae EE, Kronstad JW, DeAngelis YM, Reeder NL, Johnstone KR, Leland M, Fieno AM, Begley WM, Sun Y, Lacey MP, Chaudhary T, Keough T, Chu L, Sears R, Yuan B, Dawson TL (2007) Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Proc Nat Acad Sci USA 104:18730–18735

    Article  PubMed  CAS  Google Scholar 

  • Yamaguchi S (2008) Gibberellin metabolism and its regulation. Annu Rev Plant Biol 59:225–251

    Article  PubMed  CAS  Google Scholar 

  • Yang G, Rose MS, Turgeon BG, Yoder OC (1996) A polyketide synthase is required for fungal virulence and production of the polyketide T-toxin. Plant Cell 8:2139–2150

    PubMed  CAS  Google Scholar 

  • Young C, McMillan L, Telfer E, Scott B (2001) Molecular cloning and genetic analysis of an indole-diterpene gene cluster from Penicillium paxilli. Mol Microbiol 39:754–764

    Article  PubMed  CAS  Google Scholar 

  • Young CA, Bryant MK, Christensen MJ, Tapper BA, Bryan GT, Scott B (2005) Molecular cloning and genetic analysis of a symbiosis-expressed gene cluster for lolitrem biosynthesis from a mutualistic endophyte of perennial ryegrass. Mol Genet Genomics 274:13–29

    Article  PubMed  CAS  Google Scholar 

  • Young CA, Felitti S, Shields K, Spangenberg G, Johnson RD, Bryan GT, Saikia S, Scott B (2006) A complex gene cluster for indole-diterpene biosynthesis in the grass endophyte Neotyphodium lolii. Fungal Genet Biol 43:679–693

    Article  PubMed  CAS  Google Scholar 

  • Young CA, Tapper BA, May K, Moon CD, Schardl CL, Scott B (2009) Indole-diterpene biosynthetic capability of Epichloe endophytes as predicted by ltm gene analysis. Appl Environ Microbiol 75:2200–2211

    Article  PubMed  CAS  Google Scholar 

  • Youngchim S, Hay RJ, Hamilton AJ (2005) Melanization of Penicillium marneffei in vitro and in vivo. Microbiology 151:291–299

    Article  PubMed  CAS  Google Scholar 

  • Zhang A, Lu P, Dahl-Roshak AM, Paress PS, Kennedy S, Tkacz JS, An Z (2003) Efficient disruption of a polyketide synthase gene ( pks1) required for melanin synthesis through Agrobacterium-mediated transformation of Glarea lozoyensis. Mol Genet Genomics 268:645–655

    PubMed  CAS  Google Scholar 

  • Zhang S, Monahan BJ, Tkacz JS, Scott B (2004) Indole-diterpene gene cluster from Aspergillus flavus. Appl Env Microbiol 70:6875–6883

    Article  CAS  Google Scholar 

  • Zhdanova NN, Lashko TN, Redchits TI, Vasilevskaia AI, Borisiuk LG, Siniavskaia OI, Gavriliuk VI, Muzalev PN (1991) The interaction of soil micromycetes with “hot” particles in a model system. Mikrobiol Zh 53:9–17

    PubMed  CAS  Google Scholar 

  • Zhu X, Williamson PR (2004) Role of laccase in the biology and virulence of Cryptococcus neoformans. FEMS Yeast Res 5:1–10

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman WC, Blanchette RA, Burnes TA, Farrell RL (1995) Melanin and perithecial development in Ophiostoma piliferum. Mycologia 87:857–863

    Article  CAS  Google Scholar 

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Acknowledgements

We would like to thank Prof. Dr. Ulrich Kück for his support. Funding for our work comes from the German Science Foundation (Deutsche Forschungsgemeinschaft, DFG, grant NO 407/2-1) and the Protein Research Department of the Ruhr-University Bochum.

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  1. Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, 44780, Bochum, Germany

    Ines Teichert & Minou Nowrousian

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  1. Ines Teichert
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  1. , Institut für Mikrobiologie und Genetik, Georg-August-Universität Göttingen, Grisebachstr. 8, Göttingen, 37077, Germany

    Stefanie Pöggeler

  2. , Institut für Allgemeine Mikrobiologie, Friedrich-Schiller-Universität Jena, Neugasse 24, Jena, 07743, Germany

    Johannes Wöstemeyer

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Teichert, I., Nowrousian, M. (2011). 10 Evolution of Genes for Secondary Metabolism in Fungi. In: Pöggeler, S., Wöstemeyer, J. (eds) Evolution of Fungi and Fungal-Like Organisms. The Mycota, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19974-5_10

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