Abstract
Lipids play a central role in biology. As pointed out earlier (Chap. 2), one of the most important biological structures, biological membranes, is composed of lipids. In addition, lipids are important players in the storage of energy-rich compounds and many hormones and vitamins are lipids.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Brady L, Brzozowski AM, Derewenda ZS, Dodson E, Dodson G, Tolley S, Turkenburg JP, ChristiansonL Huge-Jensen B, Norskov L, Thim L, Menge U (1990) A serine protease triad forms the catalytic centre of a triacylglycerol lipase. Nature 343:767–770
Knoop F (1904) Der Abbau Aromatischer Fettsauren im Tierkoper. Beitr Chem Physiol Pathol 6:150–162
Dakin HD (1909) The mode of oxidation in the animal organism of phenyl derivatives of fatty acids. IV Further studies on the fate of phenylpropionic acid and some of its derivatives. J Biol Chem 6:203–219
Lynen F, Reichert E (1951) The chemical structure of activated acetic acid. Angew Chem 63:47–48
Hisanaga Y, Ago H, Nakagania J, Hanada K, Ida K, Yamamoto M, Hori T, Arii Y, Sugahara M, Kuramitsu S, Yokoyama S, Miyano M (2004) Structural basis of the substrate-specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer. J Biol Chem 279:31717–31726
Bieber LL (1988) Carnitine. Annu Rev Biochem 88:261–283
Lynen F, Ochoa S (1953) Enzymes of fatty acid metabolism. Biochim Biophys Acta 12:299–314
Langdon RG (1957) The biosynthesis of fatty acids in rat liver. J Biol Chem 226:615–629
Majerus PW, Alberts AW, Vagelos PR (1964) The acyl carrier protein of fatty acid synthesis: purification, physical properties, and substrate binding site. Proc Natl Acad Sci USA 51:1231–1238
Stetten DW Jr, Schoenheimer R (1940) The conversion of palmitic acid into stearic and palmitoleic acids in rats. J Biol Chem 133:329–345
Wells TN (1991) ATP-Citate lyase from rat liver. Characterization of the citryl-enzyme complexes. Eur J Biochem 199:163–168
Zhang S, Kim K-H (1995) Glucose activation of acetyl-CoA carboxylase in association with insulin sectrtion in a pancreatic β-cell line. J Endocrinol 147:33–41
Witters LA, Watts TD, Daniels DL, Evans JL (1988) Insulin stimulates the dephosphorylation and activation of acetyl-CoA carboxylase. Proc Natl Acad Sci USA 85:5473–5477
Weinhouse S, Medes G, Floyd NF (1944) Fatty acid metabolism. The mechanism of ketone body synthesis from fatty acids with isotopic carbon as tracer. J Biol Chem 155:143–151
Brown MS, and Goldstein JL (1985) A receptor mediated pathway for cholesterol homeostatis. Nobel Lecture, 9 December 1985, 284–324
Little HN, Bloch K (1950) Studies on the utilization of acetic acid for biological synthesis of cholesterol. J Biol Chem 183:33–46
Rudney H (1957) The biosynthesis of β-hydroxy-β-methylglutaric acid. J Biol Chem 227:363–377
Ruzicka L (1953) The isoprene rule and the biogenesis of terpenic compounds. Experientia 9:357–367
Maudgal RK, Tchen TT, Bloch K (1958) 1,2-methyl shifts in the cyclization of squalene to cholesterol. J Am Chem Soc 80:2589–2590
Bloch K (1964) The biological synthesis of cholesterol. Nobel Lecture, 11 December 1964, 78–100
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Fromm, H.J., Hargrove, M.S. (2012). Lipid Metabolism. In: Essentials of Biochemistry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19624-9_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-19624-9_12
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-19623-2
Online ISBN: 978-3-642-19624-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)