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Adventure in Asymmetric Hydrogenation: Synthesis of Chiral Phosphorus Ligands and Asymmetric Hydrogenation of Heteroaromatics

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Asymmetric Catalysis from a Chinese Perspective

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 36))

Abstract

Catalytic asymmetric hydrogenations of prochiral unsaturated compounds, such as olefins, ketones, and imines, have been intensively studied and are considered as a versatile method of the synthesis of chiral compounds due to atom economy and operational simplicity. Since 2002, we mainly focused on synthesis of new phosphorus ligands, asymmetric hydrogenation of heteroaromatic compounds and palladium-catalyzed asymmetric hydrogenation. Significant contribution was made in the Dalian Institute of Chemical Physics. In this chapter, we hope to share our experience and adventure in the development of chiral monophosphite ligands and phosphine–phosphoramidite ligands, asymmetric hydrogenation of heteroaromatic compounds, and the development of new homogeneous palladium catalytic hydrogenation system, which have a wide range of applications in synthesis of chiral compounds.

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Authors and Affiliations

  1. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, P.R. China

    Xiang-Ping Hu, Duo-Sheng Wang, Chang-Bin Yu, Yong-Gui Zhou & Zhuo Zheng

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  1. Xiang-Ping Hu
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  2. Duo-Sheng Wang
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  3. Chang-Bin Yu
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  4. Yong-Gui Zhou
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  5. Zhuo Zheng
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Correspondence to Yong-Gui Zhou .

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Editors and Affiliations

  1. Shanghai Institute of Organic Chemistry, State Key Laboratory of Organometallic, Chinese Academy of Sciences, Fenglin Lu 354, Shanghai, 200032, China, People's Republic

    Shengming Ma

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Hu, XP., Wang, DS., Yu, CB., Zhou, YG., Zheng, Z. (2011). Adventure in Asymmetric Hydrogenation: Synthesis of Chiral Phosphorus Ligands and Asymmetric Hydrogenation of Heteroaromatics. In: Ma, S. (eds) Asymmetric Catalysis from a Chinese Perspective. Topics in Organometallic Chemistry, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19472-6_10

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