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Biochemical and Microbial Aspects of Oral Malodor Production

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Breath Odors

Abstract

There is ample evidence that in the large majority of cases, oral malodor derives from bacterial activity within the oral cavity. It is also likely that most cases of odor deriving from the nasal passages and tonsils are also bacterial in origin. One indication for this is the transient reduction of oral malodor observed following local antiseptic treatment (e.g., mouthwash), and the elimination of many non-oral cases of halitosis following ­systemic antibiotic treatment.

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References

  • Amano, A., Yoshida, Y., Oho, T., Koga, T.: Monitoring ammonia to assess halitosis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 94(6), 692–696 (2002)

    Article  PubMed  Google Scholar 

  • Berg, M., Fosdick, L.S.: Studies in periodontal disease: II. Putrefactive organisms in the mouth. J. Dent. Res. 25, 73–81 (1946)

    Article  PubMed  Google Scholar 

  • Berg, M., Burrill, D.Y., Fosdick, L.S.: Chemical studies in periodontal disease III: putrefaction of salivary proteins. J. Dent. Res. 25, 231–246 (1946)

    Article  PubMed  Google Scholar 

  • Claus, D., Geypens, B., Rutgeerts, P., Ghyselen, J., Hoshi, K., Van Steenberghe, D., Ghoos, Y.: Where gastroenterology and periodontology meets: determination of oral volatile organic ­compounds using closed loop trapping and high resolution gas chromatography ion trap detection. In: Van Steenberghe, D., Rosenberg, M. (eds.) Bad breath a multidisciplinary approach, pp. 15–27. Leuven University Press, Leuven (1996)

    Google Scholar 

  • Codipilly, D.P., Kaufman, H.W., Kleinberg, I.: Use of a novel group of oral malodor measurements to evaluate an anti-oral malodor mouthrinse (TriOralTM) in humans. J. Clin. Dent. 15(4), 98–104 (2004)

    PubMed  Google Scholar 

  • Cooke, M., Leeves, N., White, C.: Time profile of putrescine, cadaverine, indole and skatole in human saliva. Arch. Oral Biol. 48(4), 323–327 (2003)

    Article  PubMed  Google Scholar 

  • Fosdick, L.S., Piez, K.A.: Chemical studies in periodontal disease. X. Pap. chromatographic investigation putrefaction associated periodontitis. J. Dent. Res. 32(1), 87–100 (1953)

    Article  PubMed  Google Scholar 

  • Gochman, N., Meyer, R.K., Blackwell, R.Q., Fosdick, L.S.: The amino acid decarboxylase of salivary sediment. J. Dent. Res. 38, 998–1003 (1959)

    Article  PubMed  Google Scholar 

  • Goldberg, S., Kozlovsky, A., Gordon, D., Gelernter, I., Sintov, A., Rosenberg, M.: Cadaverine as a putative component of oral malodor. J. Dent. Res. 73(6), 1168–1172 (1994)

    PubMed  Google Scholar 

  • Greenstein, R.B., Goldberg, S., Marku-Cohen, S., Sterer, N., Rosenberg, M.: Reduction of oral malodor by oxidizing lozenges. J. Periodontol. 68(12), 1176–1181 (1997)

    Article  PubMed  Google Scholar 

  • Haraszthy, V.I., Zambon, J.J., Sreenivasan, P.K., Zambon, M.M., Gerber, D., Rego, R., Parker, C.: Identification of oral bacterial species associated with halitosis. J. Am. Dent. Assoc. 138(8), 1113–1120 (2007)

    PubMed  Google Scholar 

  • Hartley, M.G., El Maaytah, M.A., McKenzie, C., Greenman, J.: The tongue microbiota of low odour and malodourous individuals. Microb. Ecol. Health Dis. 9, 215–223 (1996)

    Article  Google Scholar 

  • Kato, H., Yoshida, A., Awano, S., Ansai, T., Takehara, T.: Quantitative detection of volatile sulfur compound- producing microorganisms in oral specimens using real-time PCR. Oral Dis. 11(Suppl 1), 67–71 (2005)

    Article  PubMed  Google Scholar 

  • Kazor, C.E., Mitchell, P.M., Lee, A.M., Stokes, L.N., Loesche, W.J., Dewhirst, F.E., Paster, B.J.: Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients. J. Clin. Microbiol. 41(2), 558–563 (2003)

    Article  PubMed  Google Scholar 

  • Kleinberg, I., Codipilly, D.M.: The biological basis of oral malodor formation. In: Rosenberg, M. (ed.) Bad breath: research perspectives, pp. 13–39. Ramot publishing Tel Aviv University, Tel Aviv (1997)

    Google Scholar 

  • Kleinberg, I., Wolff, M.S., Codipilly, D.M.: Role of saliva in oral dryness, oral feel and oral malodour. Int. Dent. J. 52(Suppl 3), 236–240 (2002)

    PubMed  Google Scholar 

  • Kostelc, J.G., Preti, G., Zelson, P.R., Stoller, N.H., Tonzetich, J.: Salivary volatiles as indicators of periodontitis. J. Periodontal Res. 15(2), 185–192 (1980)

    Article  PubMed  Google Scholar 

  • Kurata, H., Awano, S., Yoshida, A., Ansai, T., Takehara, T.: The prevalence of periodontopathogenic bacteria in saliva is linked to periodontal health status and oral malodour. J. Med. Microbiol. 57(Pt 5), 636–642 (2008)

    Article  PubMed  Google Scholar 

  • Mackie, R.I., Stroot, P.G., Varel, V.H.: Biochemical identification and biological origin of key odor components in livestock waste. J. Anim. Sci. 76(5), 1331–1342 (1998)

    PubMed  Google Scholar 

  • McNamara, T.F., Alexander, J.F., Lee, M.: The role of microorganisms in the production of oral malodor. Oral Surg. Oral Med. Oral Pathol. 34(1), 41–48 (1972)

    Article  PubMed  Google Scholar 

  • Persson, S., Edlund, M.B., Claesson, R., Carlsson, J.: The formation of hydrogen sulfide and methyl mercaptan by oral bacteria. Oral Microbiol. Immunol. 5(4), 195–201 (1990)

    Article  PubMed  Google Scholar 

  • Riggio, M.P., Lennon, A., Rolph, H.J., Hodge, P.J., Donaldson, A., Maxwell, A.J., Bagg, J.: Molecular identification of bacteria on the tongue dorsum of subjects with and without halitosis. Oral Dis. 14(3), 251–258 (2008)

    Article  PubMed  Google Scholar 

  • Ross, B.M., Dadgostar, N., Bloom, M., McKeown, L.: The analysis of oral air using selected ion flow tube mass spectrometry in persons with and without a history of oral malodour. Int. J. Dent. Hyg. 7(2), 136–143 (2009)

    Article  PubMed  Google Scholar 

  • Shiota, T., Kunkel Jr., M.F.: In vitro chemical and bacterial changes in saliva. J. Dent. Res. 37(5), 780–787 (1958)

    Article  PubMed  Google Scholar 

  • Sterer, N., Rosenberg, M.: Streptococcus salivarius promotes mucin putrefaction and malodor production by Porphyromonas gingivalis. J. Dent. Res. 85(10), 910–914 (2006)

    Article  PubMed  Google Scholar 

  • Sterer, N., Greenstein, R.B., Rosenberg, M.: Beta-galactosidase activity in saliva is associated with oral malodor. J. Dent. Res. 81(3), 182–185 (2002)

    Article  PubMed  Google Scholar 

  • Sterer N, Shaharabany M, Rosenberg M: β-Galactosidase activity and H2S production in an experimental oral biofilm. J. Breath Res. 3, 4pp (2009). doi:10.1088/1752-7155/3/1/016006

    Google Scholar 

  • Tanaka, M., Yamamoto, Y., Kuboniwa, M., Nonaka, A., Nishida, N., Maeda, K., Kataoka, K., Nagata, H., Shizukuishi, S.: Contribution of periodontal pathogens on tongue dorsa analyzed with real-time PCR to oral malodor. Microbes Infect. 6(12), 1078–1083 (2004)

    Article  PubMed  Google Scholar 

  • Tonzetich, J.: Direct gas chromatographic analysis of sulphur compounds in mouth air in man. Arch. Oral Biol. 16(6), 587–597 (1971)

    Article  PubMed  Google Scholar 

  • Tonzetich, J., Richter, V.J.: Evaluation of volatile odoriferous components of saliva. Arch. Oral Biol. 16, 39–46 (1964)

    Article  Google Scholar 

  • Tonzetich, J., Eigen, E., King, W.J., Weiss, S.: Volatility as a factor in the inability of certain amines and indole to increase the odour of saliva. Arch. Oral Biol. 12(10), 1167–1175 (1967)

    Article  PubMed  Google Scholar 

  • Torresyap, G., Haffajee, A.D., Uzel, N.G., Socransky, S.S.: Relationship between periodontal pocket sulfide levels and subgingival species. J. Clin. Periodontol. 30(11), 1003–1010 (2003)

    Article  PubMed  Google Scholar 

  • van den Velde, S., Quirynen, M., van Hee, P., van Steenberghe, D.: Halitosis associated volatiles in breath of healthy subjects. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 853(1–2), 54–61 (2007)

    PubMed  Google Scholar 

  • Van den Velde, S., van Steenberghe, D., Van Hee, P., Quirynen, M.: Detection of odorous compounds in breath. J. Dent. Res. 88(3), 285–289 (2009)

    Article  PubMed  Google Scholar 

  • Washio, J., Sato, T., Koseki, T., Takahashi, N.: Hydrogen sulfide-producing bacteria in tongue biofilm and their relationship with oral malodour. J. Med. Microbiol. 54(9), 889–895 (2005)

    Article  PubMed  Google Scholar 

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Correspondence to Nir Sterer DMD, PhD .

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Sterer, N., Rosenberg, M. (2011). Biochemical and Microbial Aspects of Oral Malodor Production. In: Breath Odors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19312-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-19312-5_3

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