Abstract
Many cell types undergo dramatic changes in shape throughout the cell cycle. For individual cells, a tight control of cell shape is crucial during cell division, but also in interphase, for example during cell migration. Moreover, cell cycle-related cell shape changes have been shown to be important for tissue morphogenesis in a number of developmental contexts. Cell shape is the physical result of cellular mechanical properties and of the forces exerted on the cell. An understanding of the causes and repercussions of cell shape changes thus requires knowledge of both the molecular regulation of cellular mechanics and how specific changes in cell mechanics in turn effect global shape changes. In this chapter, we provide an overview of the current knowledge on the control of cell morphology, both in terms of general cell mechanics and specifically during the cell cycle.
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References
Aigouy B, Farhadifar R, Staple DB, Sagner A, Röper JC, Jülicher F, Eaton S (2010) Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila. Cell 142:773–786
Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P (1998) Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393:805–809
Arcuri F, Papa S, Meini A, Carducci A, Romagnoli R, Bianchi L, Riparbelli MG, Sanchez J-C, Palmi M, Tosi P, Cintorino M (2005) The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. Biol Reprod 73:745–751
Azoury J, Lee KW, Georget V, Rassinier P, Leader B, Verlhac MH (2008) Spindle positioning in mouse oocytes relies on a dynamic meshwork of actin filaments. Curr Biol 18:1514–1519
Baena-López LA, Baonza A, García-Bellido A (2005) The orientation of cell divisions determines the shape of Drosophila organs. Curr Biol 15:1640–1644
Baker J, Garrod D (1993) Epithelial cells retain junctions during mitosis. J Cell Sci 104:415–425
Bamburg JR, McGough A, Ono S (1999) Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol 9:364–370
Barros CS, Phelps CB, Brand AH (2003) Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport. Dev Cell 5:829–840
Bazile F, Pascal A, Arnal I, Le Clainche C, Chesnel F, Kubiak JZ (2009) Complex relationship between TCTP, microtubules and actin microfilaments regulates cell shape in normal and cancer cells. Carcinogenesis 30:555–565
Bereiter-Hahn J (2005) Mechanics of crawling cells. Med Eng Phys 27:743–753
Bereiter-Hahn J, Anderson OR, Reif WE (1987) Cytomechanics. The mechanical basis of cell form and structure. Springer, Berlin, Germany
Berlin RD, Oliver JM (1980) Surface functions during mitosis. II. Quantitation of pinocytosis and kinetic characterization of the mitotic cycle with a new fluorescence technique. J Cell Biol 85:660–671
Berlin RD, Oliver JM, Walter RJ (1978) Surface functions during mitosis I: phagocytosis, pinocytosis and mobility of surface-bound ConA. Cell 15:327–341
Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM (2005) Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 24:5333–5343
Bittig T, Wartlick O, González-Gaitán M, Jülicher F (2009) Quantification of growth asymmetries in developing epithelia. Eur Phys J E 30:93–99
Blanchard GB, Kabla AJ, Schultz NL, Butler LC, Sanson B, Gorfinkiel N, Mahadevan L, Adams RJ (2009) Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation. Nat Methods 6:458–464
Blot J, Chartrain I, Roghi C, Philippe M, Tassan J-P (2002) Cell cycle regulation of pEg3, a new Xenopus protein kinase of the KIN1/PAR-1/MARK family. Dev Biol 241:327–338
Bluemink JG, de Laat SW (1973) New membrane formation during cytokinesis in normal and cytochalasin B-treated eggs of Xenopus laevis. J Cell Biol 59:89–108
Boal D (2002) Mechanics of the cell. Cambridge University Press, Cambridge, UK
Borghi N, Nelson WJ (2009) Intercellular adhesion in morphogenesis: molecular and biophysical considerations. Curr Top Dev Biol 89:1–32
Bos JL (2005) Linking rap to cell adhesion. Curr Opin Cell Biol 17:123–128
Boucrot E, Kirchhausen T (2007) Endosomal recycling controls plasma membrane area during mitosis. Proc Natl Acad Sci USA 104:7939–7944
Boucrot E, Kirchhausen T (2008) Mammalian cells change volume during mitosis. PLoS One 3:e1477
Bradley R, Woods A, Carruthers L, Rees D (1980) Cytoskeleton changes in fibroblast adhesion and detachment. J Cell Sci 43:379–390
Bray D, White JG (1988) Cortical flow in animal cells. Science 239:883–888
Bretscher A, Edwards K, Fehon RG (2002) ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 3:586–599
Bringmann H, Hyman AA (2005) A cytokinesis furrow is positioned by two consecutive signals. Nature 436:731–734
Britch M, Allen TD (1980) The modulation of cellular contractility and adhesion by trypsin and EGTA. Exp Cell Res 125:221–231
Brochard-Wyart F, Borghi N, Cuvelier D, Nassoy P (2006) Hydrodynamic narrowing of tubes extruded from cells. Proc Natl Acad Sci USA 103:7660–7663
Brodland GW, Conte V, Cranston PG, Veldhuis J, Narasimhan S, Hutson MS, Jacinto A, Ulrich F, Baum B, Miodownik M (2010) Video force microscopy reveals the mechanics of ventral furrow invagination in Drosophila. Proc Natl Acad Sci USA 107:22111–22116
Brown MJ, Hallam JA, Colucci-Guyon E, Shaw S (2001) Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments. J Immunol 166:6640–6646
Burgess DR, Chang F (2005) Site selection for the cleavage furrow at cytokinesis. Trends Cell Biol 15:156–162
Burgess RW, Deitcher DL, Schwarz TL (1997) The synaptic protein Syntaxin1 is required for cellularization of Drosophila embryos. J Cell Biol 138:861–875
Butler LC, Blanchard GB, Kabla AJ, Lawrence NJ, Welchman DP, Mahadevan L, Adams RJ, Sanson B (2009) Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension. Nat Cell Biol 11:859–864
Cabernard C, Prehoda KE, Doe CQ (2010) A spindle-independent cleavage furrow positioning pathway. Nature 467:91–94
Caille N, Thoumine O, Tardy Y, Meister J-J (2002) Contribution of the nucleus to the mechanical properties of endothelial cells. J Biomech 35:177–187
Cao LG, Wang YL (1990b) Mechanism of the formation of contractile ring in dividing cultured animal cells. I. Recruitment of preexisting actin filaments into the cleavage furrow. J Cell Biol 110:1089–1095
Cao LG, Wang YL (1990a) Mechanism of the formation of contractile ring in dividing cultured animal cells. II. Cortical movement of microinjected actin filaments. J Cell Biol 111:1905–1911
Carlsson AE (2003) Growth velocities of branched actin networks. Biophys J 84:2907–2918
Carreno S, Kouranti I, Glusman ES, Fuller MT, Echard A, Payre F (2008) Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells. J Cell Biol 180:739–746
Chackalaparampil I, Shalloway D (1988) Altered phosphorylation and activation of PP60c-src during fibroblast mitosis. Cell 52:801–810
Charras G, Paluch E (2008) Blebs lead the way: how to migrate without lamellipodia. Nat Rev Mol Cell Biol 9:730–736
Charras GT, Yarrow JC, Horton MA, Mahadevan L, Mitchison TJ (2005) Non-equilibration of hydrostatic pressure in blebbing cells. Nature 435:365–369
Charras GT, Coughlin M, Mitchison TJ, Mahadevan L (2008) Life and times of a cellular bleb. Biophys J 94:1836–1853
Chartrain I, Couturier A, Tassan J-P (2006) Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. Biol Cell 98:253–263
Cheng NN, Kirby CM, Kemphues KJ (1995) Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3. Genetics 139:549–559
Chew T-L, Masaracchia RA, Goeckeler ZM, Wysolmerski RB (1998) Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (γ-PAK). J Muscle Res Cell Motil 19:839–854
Chou YH, Bischoff JR, Beach D, Goldman RD (1990) Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin. Cell 62:1063–1071
Chu YS, Dufour S, Thiery JP, Perez E, Pincet F (2005) Johnson-Kendall-Roberts theory applied to living cells. Phys Rev Lett 94:028102
Concha ML, Adams RJ (1998) Oriented cell divisions and cellular morphogenesis in the zebrafish gastrula and neurula: a time-lapse analysis. Development 125:983–994
Coniglio SJ, Zavarella S, Symons MH (2008) Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol 28:4162–4172
Cramer LP, Mitchison TJ (1997) Investigation of the mechanism of retraction of the cell margin and rearward flow of nodules during mitotic cell rounding. Mol Biol Cell 8:109–119
Cui C, Yang X, Chuai M, Glazier JA, Weijer CJ (2005) Analysis of tissue flow patterns during primitive streak formation in the chick embryo. Dev Biol 284:37–47
Cunningham CC, Gorlin JB, Kwiatkowski DJ, Hartwig JH, Janmey PA, Byers R, Stossel TP (1992) Actin-binding protein requirement for cortical stability and efficient locomotion. Science 255:325–327
Cuvelier D, Théry M, Chu Y-S, Dufour S, Thiéry J-P, Bornens M, Nassoy P, Mahadevan L (2007) The universal dynamics of cell spreading. Curr Biol 17:694–699
Dai J, Ting-Beall HP, Hochmuth RM, Sheetz MP, Titus MA (1999) Myosin I contributes to the generation of resting cortical tension. Biophys J 77:1168–1176
Dao VT, Dupuy AG, Gavet O, Caron E, de Gunzburg J (2009) Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis. J Cell Sci 122:2996–3004
David-Pfeuty T, Nouvian-Dooghe Y (1990) Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells. J Cell Biol 111:3097–3116
Davidson L, von Dassow M, Zhou J (2009) Multi-scale mechanics from molecules to morphogenesis. Int J Biochem Cell Biol 41:2147–2162
Dayel MJ, Akin O, Landeryou M, Risca V, Mogilner A, Mullins RD (2009) In silico reconstitution of actin-based symmetry breaking and motility. PLoS Biol 7:e1000201
DeBiasio RL, LaRocca GM, Post PL, Taylor DL (1996) Myosin II transport, organization, and phosphorylation: evidence for cortical flow/solation-contraction coupling during cytokinesis and cell locomotion. Mol Biol Cell 7:1259–1282
DiMilla PA, Barbee K, Lauffenburger DA (1991) Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophys J 60:15–37
Dinarina A, Pugieux C, Corral MM, Loose M, Spatz J, Karsenti E, Nédélec F (2009) Chromatin shapes the mitotic spindle. Cell 138:502–513
Diz-Muñoz A, Krieg M, Bergert M, Ibarlucea-Benitez I, Muller DJ, Paluch E, Heisenberg CP (2010) Control of directed cell migration in vivo by membrane-to-cortex attachment. PLoS Biol 8:e1000544
Drewes G, Ebneth A, Preuss U, Mandelkow E-M, Mandelkow E (1997) MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89:297–308
Effler JC, Kee Y-S, Berk JM, Tran MN, Iglesias PA, Robinson DN (2006) Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Curr Biol 16:1962–1967
Eppinga RD, Li Y, Lin JL-C, Mak AS, Lin JJ-C (2006) Requirement of reversible caldesmon phosphorylation at P21-activated kinase-responsive sites for lamellipodia extensions during cell migration. Cell Motil Cytoskeleton 63:543–562
Erickson CA, Trinkaus JP (1976) Microvilli and blebs as sources of reserve surface membrane during cell spreading. Exp Cell Res 99:375–384
Estecha A, Sánchez-Martín L, Puig-Kröger A, Bartolomé RA, Teixidó J, Samaniego R, Sánchez-Mateos P (2009) Moesin orchestrates cortical polarity of melanoma tumour cells to initiate 3D invasion. J Cell Sci 122:3492–3501
Evans E, Yeung A (1989) Apparent viscosity and cortical tension of blood granulocytes determined by micropipet aspiration. Biophys J 56:151–160
Fackler OT, Grosse R (2008) Cell motility through plasma membrane blebbing. J Cell Biol 181:879–884
Farhadifar R, Röper J-C, Aigouy B, Eaton S, Jülicher F (2007) The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing. Curr Biol 17:2095–2104
Fehon RG, McClatchey AI, Bretscher A (2010) Organizing the cell cortex: the role of ERM proteins. Nat Rev Mol Cell Biol 11:276–287
Fink J, Carpi N, Betz T, Bétard A, Chebah M, Azioune A, Bornens M, Sykes C, Fetler L, Cuvelier D, Piel M (2011) External forces control mitotic spindle positioning. Nat Cell Biol (in press)
Fishkind D, Wang YL (1993) Orientation and three-dimensional organization of actin filaments in dividing cultured cells. J Cell Biol 123:837–848
Fishkind D, Cao L, Wang YL (1991) Microinjection of the catalytic fragment of myosin light chain kinase into dividing cells: effects on mitosis and cytokinesis. J Cell Biol 114:967–975
Flemming W (1895) Zur Mechanik der Zelltheilung. Archiv für Mikroscopische Anatomie und Entwicklungsmechanik 46:696–701
Folkman J, Moscona A (1978) Role of cell shape in growth control. Nature 273:345–349
Foster DB, Shen L-H, Kelly J, Thibault P, Van Eyk JE, Mak AS (2000) Phosphorylation of Caldesmon by p21-activated kinase. J Biol Chem 275:1959–1965
Fujibuchi T, Abe Y, Takeuchi T, Imai Y, Kamei Y, Murase R, Ueda N, Shigemoto K, Yamamoto H, Kito K (2005) AIP1/WDR1 supports mitotic cell rounding. Biochem Biophys Res Commun 327:268–275
Gauthier NC, Rossier OM, Mathur A, Hone JC, Sheetz MP (2009) Plasma membrane area increases with spread area by exocytosis of a GPI-anchored protein compartment. Mol Biol Cell 20:3261–3272
Gavet O, Pines J (2010) Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. Dev Cell 18:533–543
Geldmacher-Voss B, Reugels AM, Pauls S, Campos-Ortega JA (2003) A 90˚ rotation of the mitotic spindle changes the orientation of mitoses of zebrafish neuroepithelial cells. Development 130:3767–3780
Giet O, Van Bockstaele DR, Di Stefano I, Huygen S, Greimers R, Beguin Y, Gothot A (2002) Increased binding and defective migration across fibronectin of cycling hematopoietic progenitor cells. Blood 99:2023–2031
Glotzer M (2001) Animal cell cytokinesis. Annu Rev Cell Dev Biol 17:351–386
Glotzer M (2004) Cleavage furrow positioning. J Cell Biol 164:347–351
Gong Y, Mo C, Fraser SE (2004) Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature 430:689–693
Gorfinkiel N, Blanchard GB, Adams RJ, Martinez Arias A (2009) Mechanical control of global cell behaviour during dorsal closure in Drosophila. Development 136:1889–1898
Goss JW, Toomre DK (2008) Both daughter cells traffic and exocytose membrane at the cleavage furrow during mammalian cytokinesis. J Cell Biol 181:1047–1054
Gotz M, Huttner WB (2005) The cell biology of neurogenesis. Nat Rev Mol Cell Biol 6:777–788
Graham JM, Sumner MCB, Curtis DH, Pasternak CA (1973) Sequence of events in plasma membrane assembly during the cell cycle. Nature 246:291–295
Gray D, Plusa B, Piotrowska K, Na J, Tom B, Glover DM, Zernicka-Goetz M (2004) First cleavage of the mouse embryo responds to change in egg shape at fertilization. Curr Biol 14:397–405
Habela CW, Sontheimer H (2007) Cytoplasmic volume condensation is and integral part of mitosis. Cell Cycle 6:1613–1620
Hanakam F, Albrecht R, Eckerskorn C, Matzner M, Gerisch G (1996) Myristoylated and non-myristoylated forms of the pH sensor protein hisactophilin II: intracellular shuttling to plasma membrane and nucleus monitored in real time by a fusion with green fluorescent protein. EMBO J 15:2935–2943
Hara K (1971) Cinematographic observation of “surface contraction waves” (SCW) during the early cleavage of axolotl eggs. Dev Genes Evol 167:183–186
Hara K, Tydeman P, Kirschner M (1980) A cytoplasmic clock with the same period as the division cycle in Xenopus eggs. Proc Natl Acad Sci USA 77:462–466
Haubensak W, Attardo A, Denk W, Huttner WB (2004) Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis. Proc Natl Acad Sci USA 101:3196–3201
Henderson D, Rohrschneider L (1987) Cytoskeletal association of pp 60src: the transforming protein of the rous sarcoma virus. Exp Cell Res 168:411–421
Hertzler PL, Clark WH Jr (1992) Cleavage and gastrulation in the shrimp Sicyonia ingentis: invagination is accompanied by oriented cell division. Development 116:127–140
Hilgenfeldt S, Erisken S, Carthew RW (2008) Physical modeling of cell geometric order in an epithelial tissue. Proc Natl Acad Sci USA 105:907–911
Hiramoto Y (1957) The thickness of the cortex and the refractive index of the protoplasm in Sea urchin eggs. Embryologia 3:361–374
Hochmuth RM (2000) Micropipette aspiration of living cells. J Biomech 33:15–22
Hoffman BD, Crocker JC (2009) Cell mechanics: dissecting the physical responses of cells to force. Annu Rev Biomed Eng 11:259–288
Hotulainen P, Paunola E, Vartiainen MK, Lappalainen P (2005) Actin-depolymerizing factor and Cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell 16:649–664
Hufnagel L, Teleman AA, Rouault H, Cohen SM, Shraiman BI (2007) On the mechanism of wing size determination in fly development. Proc Natl Acad Sci USA 104:3835–3840
Hutson MS, Tokutake Y, Chang MS, Bloor JW, Venakides S, Kiehart DP, Edwards GS (2003) Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. Science 300:145–149
Ingber DE (1993) The riddle of morphogenesis: a question of solution chemistry or molecular cell engineering? Cell 75:1249–1252
Ingber DE (2003) Tensegrity I. Cell structure and hierarchical systems biology. J Cell Sci 116:1157–1173
Iwamoto H, Nakamuta M, Tada S, Sugimoto R, Enjoji M, Nawata H (2000) A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth. J Hepatol 32:762–770
Iwasaki T, Shinkai K, Mukai M, Yoshioka K, Fujii Y, Nakahara K, Matsuda H, Akedo H (1995) Cell-cycle-dependent invasion in vitro by rat ascites hepatoma cells. Int J Cancer 63:282–287
Jaffe AB, Hall A (2005) Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21:247–269
Janmey PA, McCulloch CA (2007) Cell mechanics: integrating cell responses to mechanical stimuli. Annu Rev Biomed Eng 9:1–34
Janoueix-Lerosey I, Fontenay M, Tobelem G, Tavitian A, Polakis P, Degunzburg J (1994) Phosphorylation of Rap1GAP during the cell cycle. Biochem Biophys Res Commun 202:967–975
Janson ME, Loughlin R, Loïodice I, Fu C, Brunner D, Nédélec FJ, Tran PT (2007) Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast. Cell 128:357–368
Käfer J, Hayashi T, Marée AFM, Carthew RW, Graner F (2007) Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina. Proc Natl Acad Sci USA 104:18549–18554
Kaji N, Muramoto A, Mizuno K (2008) LIM kinase-mediated Cofilin phosphorylation during mitosis is required for precise spindle positioning. J Biol Chem 283:4983–4992
Kamasaki T, Osumi M, Mabuchi I (2007) Three-dimensional arrangement of F-actin in the contractile ring of fission yeast. J Cell Biol 178:765–771
Keren K, Pincus Z, Allen GM, Barnhart EL, Marriott G, Mogilner A, Theriot JA (2008) Mechanism of shape determination in motile cells. Nature 453:475–480
Kimmel CB, Warga RM, Kane DA (1994) Cell cycles and clonal strings during formation of the zebrafish central nervous system. Development 120:265–276
Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-Kinase). Science 273:245–248
King JS, Veltman DM, Georigiou M, Baum B, Insall RH (2010) SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis. J Cell Sci 123:2246–2255
Kiosses WB, Daniels RH, Otey C, Bokoch GM, Schwartz MA (1999) A role for P21-activated kinase in endothelial cell migration. J Cell Biol 147:831–844
Knutton S, Sumner MC, Pasternak CA (1975) Role of microvilli in surface changes of synchronized P815Y mastocytoma cells. J Cell Biol 66:568–576
Krieg M, Arboleda-Estudillo Y, Puech PH, Kafer J, Graner F, Muller DJ, Heisenberg CP (2008a) Tensile forces govern germ-layer organization in zebrafish. Nat Cell Biol 10:429–436
Krieg M, Helenius J, Heisenberg CP, Muller DJ (2008b) A bond for a lifetime: employing membrane nanotubes from living cells to determine receptor-ligand kinetics. Angew Chem Int Ed Engl 47:9775–9777
Kruse K, Joanny J-F, Jülicher F, Prost J, Sekimoto K (2004) Asters, vortices, and rotating spirals in active gels of polar filaments. Phys Rev Lett 92:078101
Kruse K, Joanny J-F, Jülicher F, Prost J, Sekimoto K (2005) Generic theory of active polar gels: a paradigm for cytoskeletal dynamics. Eur Phys J E 16:5–16
Kunda P, Pelling AE, Liu T, Baum B (2008) Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis. Curr Biol 18:91–101
Lamb NJC, Fernandez A, Watrin A, Labbé J-C, Cavadore J-C (1990) Microinjection of p34cdc2 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts. Cell 60:151–165
Landsberg KP, Farhadifar R, Ranft J, Umetsu D, Widmann TJ, Bittig T, Said A, Jülicher F, Dahmann C (2009) Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary. Curr Biol 19:1950–1955
Lecuit T, Lenne P-F (2007) Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis. Nat Rev Mol Cell Biol 8:633–644
Levi M, Maro B, Shalgi R (2010) The involvement of Fyn kinase in resumption of the first meiotic division in mouse oocytes. Cell Cycle 9:1577–1589
Lipowsky R, Sackmann E (1995) Structure and dynamics of membranes. Handbook of biological physics. Elsevier, Amsterdam, The Netherlands
Liu XH, Wang X (2004) The deformation of an adherent leukocyte under steady shear flow: a numerical study. J Biomech 37:1079–1085
Lomakina EB, Spillmann CM, King MR, Waugh RE (2004) Rheological analysis and measurement of neutrophil indentation. Biophys J 87:4246–4258
Lu B, Roegiers F, Jan LY, Jan YN (2001) Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409:522–525
Ma Q, Geng Y, Xu W, Wu Y, He F, Shu W, Huang M, Du H, Li M (2009) The role of translationally controlled tumor protein in tumor growth and metastasis of colon adenocarcinoma cells. J Proteome Res 9:40–49
Mabuchi I, Tsukita S, Sawai T (1988) Cleavage furrow isolated from newt eggs: contraction, organization of the actin filaments, and protein components of the furrow. Proc Natl Acad Sci USA 85:5966–5970
Maddox AS, Burridge K (2003) RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol 160:255–265
Maroto B, Ye MB, von Lohneysen K, Schnelzer A, Knaus UG (2008) P21-activated kinase is required for mitotic progression and regulates Plk1. Oncogene 27:4900–4908
Matzke R, Jacobson K, Radmacher M (2001) Direct, high-resolution measurement of furrow stiffening during division of adherent cells. Nat Cell Biol 3:607–610
Maugis B, Brugués J, Nassoy P, Guillen N, Sens P, Amblard F (2010) Dynamic instability of the intracellular pressure drives bleb-based motility. J Cell Sci 123:3884–3892
Maupin P, Pollard TD (1986) Arrangement of actin filaments and myosin-like filaments in the contractile ring and of actin-like filaments in the mitotic spindle of dividing HeLa cells. J Ultrastruct Mol Struct Res 94:92–103
Mayer M, Depken M, Bois JS, Jülicher F, Grill SW (2010) Anisotropies in cortical tension reveal the physical basis of cortical flow in polarising C. elegans zygotes. Nature 467:617–621
Mitchison JM, Swann MM (1954) The mechanical properties of the cell surface. I. The cell elastimeter. J Exp Biol 31:443–460
Mitchison TJ (1992) Actin based motility on retraction fibers in mitotic PtK2 cells. Cell Motil Cytoskeleton 22:135–151
Mitchison TJ, Charras GT, Mahadevan L (2008) Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Semin Cell Dev Biol 19:215–223
Mitsushima M, Aoki K, Ebisuya M, Matsumura S, Yamamoto T, Matsuda M, Toyoshima F, Nishida E (2010) Revolving movement of a dynamic cluster of actin filaments during mitosis. J Cell Biol 191:453–462
Miyata T, Kawaguchi A, Saito K, Kawano M, Muto T, Ogawa M (2004) Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells. Development 131:3133–3145
Montell DJ (2008) Morphogenetic cell movements: diversity from modular mechanical properties. Science 322:1502–1505
Moon A, Drubin DG (1995) The ADF/Cofilin proteins: stimulus-responsive modulators of actin dynamics. Mol Biol Cell 6:1423–1431
Morone N, Fujiwara T, Murase K, Kasai RS, Ike H, Yuasa S, Usukura J, Kusumi A (2006) Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography. J Cell Biol 174:851–862
Mukhina S, Wang YL, Murata-Hori M (2007) Alpha-actinin is required for tightly regulated remodeling of the actin cortical network during cytokinesis. Dev Cell 13:554–565
Nagasaki A, Kanada M, Uyeda TQP (2009) Cell adhesion molecules regulate contractile ring-independent cytokinesis in Dictyostelium discoideum. Cell Res 19:236–246
Nambiar R, McConnell RE, Tyska MJ (2009) Control of cell membrane tension by myosin-I. Proc Natl Acad Sci USA 106:11972–11977
Nelson CM, Jean RP, Tan JL, Liu WF, Sniadecki NJ, Spector AA, Chen CS (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Proc Natl Acad Sci USA 102:11594–11599
Neujahr R, Heizer C, Gerisch G (1997) Myosin II-independent processes in mitotic cells of Dictyostelium discoideum: redistribution of the nuclei, re-arrangement of the actin system and formation of the cleavage furrow. J Cell Sci 110:123–137
Norden C, Young S, Link BA, Harris WA (2009) Actomyosin is the main driver of interkinetic nuclear migration in the retina. Cell 138:1195–1208
O'Connell CB, Wang YL (2000) Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion. Mol Biol Cell 11:1765–1774
Ou G, Stuurman N, D’Ambrosio M, Vale RD (2010) Polarized myosin produces unequal-size daughters during asymmetric cell division. Science 330:677–680
Palecek SP, Loftus JC, Ginsberg MH, Lauffenburger DA, Horwitz AF (1997) Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature 385:537–540
Paluch E, Heisenberg C-P (2009) Biology and physics of cell shape changes in development. Curr Biol 19:R790–R799
Pasternak C, Spudich J, Elson E (1989) Capping of surface receptors and concomitant cortical tension are generated by conventional myosin. Nature 341:549–551
Perez-Mongiovi D, Chang P, Houliston E (1998) A propagated wave of MPF activation accompanies surface contraction waves at first mitosis in Xenopus. J Cell Sci 111:385–393
Pfaendtner J, De La Cruz EM, Voth GA (2010) Actin filament remodeling by actin depolymerization factor/cofilin. Proc Natl Acad Sci USA 107:7299–7304
Pollard TD (2010) Mechanics of cytokinesis in eukaryotes. Curr Opin Cell Biol 22:50–56
Pollard TD, Borisy GG (2003) Cellular motility driven by assembly and disassembly of actin filaments. Cell 112:453–465
Pollard TD, Wu JQ (2010) Understanding cytokinesis: lessons from fission yeast. Nat Rev Mol Cell Biol 11:149–155
Popowicz GM, Schleicher M, Noegel AA, Holak TA (2006) Filamins: promiscuous organizers of the cytoskeleton. Trends Biochem Sci 31:411–419
Pypaert M, Mundy D, Souter E, Labbé JC, Warren G (1991) Mitotic cytosol inhibits invagination of coated pits in broken mitotic cells. J Cell Biol 114:1159–1166
Qin Y, Meisen WH, Hao Y, Macara IG (2010) Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation. J Cell Biol 189:661–669
Rafelski SM, Alberts JB, Odell GM (2009) An experimental and computational study of the effect of ActA polarity on the speed of Listeria monocytogenes actin-based motility. PLoS Comput Biol 5:e1000434
Rand RP, Burton AC (1964) Mechanical properties of the red cell membrane. I. Membrane stiffness and intracellular pressure. Biophys J 4:115–135
Rankin S, Kirschner MW (1997) The surface contraction waves of Xenopus eggs reflect the metachronous cell-cycle state of the cytoplasm. Curr Biol 7:451–454
Rappaport R (1960) Cleavage of sand dollar eggs under constant tensile stress. J Exp Zool 144:225–231
Rappaport R (1961) Experiments concerning the cleavage stimulus in sand dollar eggs. J Exp Zool 148:81–89
Rappaport R (1996) Cytokinesis in animal cells. Cambridge University Press, Cambridge, UK
Ratner S, Jasti RK, Heppner GH (1988) Motility of murine lymphocytes during transit through cell cycle. Analysis by a new in vitro assay. J Immunol 140:583–588
Raucher D, Sheetz MP (1999) Membrane expansion increases endocytosis rate during mitosis. J Cell Biol 144:497–506
Rauzi M, Verant P, Lecuit T, Lenne P-F (2008) Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis. Nat Cell Biol 10:1401–1410
Reichl EM, Effler JC, Robinson DN (2005) The stress and strain of cytokinesis. Trends Cell Biol 15:200–206
Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock RS, Robinson DN (2009) Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I. Curr Biol 19:1421–1428
Riabowol K, Draetta G, Brizuela L, Vandre D, Beach D (1989) The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57:393–401
Riveline D, Zamir E, Balaban NQ, Schwarz US, Ishizaki T, Narumiya S, Kam Z, Geiger B, Bershadsky AD (2001) Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol 153:1175–1186
Robinson DN, Spudich JA (2004) Mechanics and regulation of cytokinesis. Curr Opin Cell Biol 16:182–188
Roche S, Fumagalli S, Courtneidge SA (1995) Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division. Science 269:1567–1569
Rodriguez-Fraticelli AE, Vergarajauregui S, Eastburn DJ, Datta A, Alonso MA, Mostov K, Martín-Belmonte F (2010) The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. J Cell Biol 189:725–738
Roux W (1894) Einleitung zum Archiv für Entwickelungsmechanik. Arch Embryol 1:1–42
Rubinfeld B, Crosier WJ, Albert I, Conroy L, Clark R, McCormick F, Polakis P (1992) Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis. Mol Cell Biol 12:4634–4642
Salbreux G (2008) Modélisation des instabilités du cortex d’actine. PhD thesis. Université Pierre et Marie Curie - Paris 6
Salbreux G, Prost J, Joanny JF (2009) Hydrodynamics of cellular cortical flows and the formation of contractile rings. Phys Rev Lett 103:058102
Sanger JW, Sanger JM (1980) Surface and shape changes during cell division. Cell Tissue Res 209:177–186
Sausedo RA, Smith JL, Schoenwolf GC (1997) Role of nonrandomly oriented cell division in shaping and bending of the neural plate. J Comp Neurol 381:473–488
Sawai T (1979) Cyclic changes in the cortical layer of non-nucleated fragments of the newt’s egg. J Embryol Exp Morphol 51:183–193
Sawai T, Yoneda M (1974) Wave of stiffness propagating along the surface of the newt egg during cleavage. J Cell Biol 60:1–7
Schenk J, Wilsch-Bräuninger M, Calegari F, Huttner WB (2009) Myosin II is required for interkinetic nuclear migration of neural progenitors. Proc Natl Acad Sci USA 106:16487–16492
Schoenwolf GC, Alvarez IS (1989) Roles of neuroepithelial cell rearrangement and division in shaping of the avian neural plate. Development 106:427–439
Schroeder TE (1990) The contractile ring and furrowing in dividing cells. Ann N Y Acad Sci 582:78–87
Schuh M, Ellenberg J (2008) A new model for asymmetric spindle positioning in mouse oocytes. Curr Biol 18:1986–1992
Schwarz EC, Neuhaus EM, Kistler C, Henkel AW, Soldati T (2000) Dictyostelium myosin IK is involved in the maintenance of cortical tension and affects motility and phagocytosis. J Cell Sci 113:621–633
Schweitzer JK, Burke EE, Goodson HV, D'Souza-Schorey C (2005) Endocytosis resumes during late mitosis and is required for cytokinesis. J Biol Chem 280:41628–41635
Seasholtz TM, Majumdar M, Kaplan DD, Brown JH (1999) Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res 84:1186–1193
Sedzinski J, Biro M, Oswald A, Tinevez JY, Salbreux G, Paluch E (2011) Polar acto-myosin contractility destabilises the position of the cleavage furrow during cytokinesis. Nature (in press)
Sells MA, Boyd JT, Chernoff J (1999) p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J Cell Biol 145:837–849
Selman GG, Waddington CH (1955) The mechanism of cell division in the cleavage of the newt’s egg. J Exp Biol 32:700–733
Sheetz MP (2001) Cell control by membrane-cytoskeleton adhesion. Nat Rev Mol Cell Biol 2:392–396
Sheetz MP, Sable JE, Döbereiner H-G (2006) Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics. Annu Rev Biophys Biomol Struct 35:417–434
Shuster CB, Burgess DR (2002) Targeted new membrane addition in the cleavage furrow is a late, separate event in cytokinesis. Proc Natl Acad Sci USA 99:3633–3638
Siegrist SE, Doe CQ (2006) Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts. Development 133:529–536
Skop AR, Bergmann D, Mohler WA, White JG (2001) Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex. Curr Biol 11:735–746
Smith LG (2001) Plant cell division: building walls in the right places. Nat Rev Mol Cell Biol 2:33–39
Solon J, Kaya A, Colombelli J, Brunner D (2009) Pulsed forces timed by a ratchet-like mechanism drive directed tissue movement during dorsal closure. Cell 137:1331–1342
Staple DB, Farhadifar R, Röper JC, Aigouy B, Eaton S, Jülicher F (2010) Mechanics and remodelling of cell packings in epithelia. Eur Phys J E 33:117–127
Steinman RM, Mellman IS, Muller WA, Cohn ZA (1983) Endocytosis and the recycling of plasma membrane. J Cell Biol 96:1–27
Stephens L, Hardin J, Keller R, Wilt F (1986) The effects of aphidicolin on morphogenesis and differentiation in the sea urchin embryo. Dev Biol 118:64–69
Stewart MP, Helenius J, Toyoda Y, Ramanathan SP, Muller DJ, Hyman AA (2011) Opposing activities of hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding. Nature 469:226–230
Strangeways T (1922) Observations on the changes seen in living cells during growth and division. Proc R Soc B 94:137–141
Strauss B, Adams RJ, Papalopulu N (2006) A default mechanism of spindle orientation based on cell shape is sufficient to generate cell fate diversity in polarised Xenopus blastomeres. Development 133:3883–3893
Suzuki K, Takahashi K (2003) Reduced cell adhesion during mitosis by threonine phosphorylation of beta1 integrin. J Cell Physiol 197:297–305
Szczepanowska J, Korn ED, Brzeska H (2006) Activation of myosin in HeLa cells causes redistribution of focal adhesions and F-actin from cell center to cell periphery. Cell Motil Cytoskeleton 63:356–374
Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ (2001) Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones. Nat Struct Mol Biol 8:701–704
Théry M, Bornens M (2006) Cell shape and cell division. Curr Opin Cell Biol 18:648–657
Théry M, Bornens M (2008) Get round and stiff for mitosis. HSFP J 2:65–71
Théry M, Racine V, Pépin A, Piel M, Chen Y, Sibarita J-B, Bornens M (2005) The extracellular matrix guides the orientation of the cell division axis. Nat Cell Biol 7:947–953
Théry M, Jiménez-Dalmaroni A, Racine V, Bornens M, Jülicher F (2007) Experimental and theoretical study of mitotic spindle orientation. Nature 447:493–496
Thompson DAW (1917) On growth and form. Cambridge University Press, Cambridge, UK
Thoumine O, Cardoso O, Meister JJ (1999) Changes in the mechanical properties of fibroblasts during spreading: a micromanipulation study. Euro Biophys J 28:222–234
Tinevez JY, Schulze U, Salbreux G, Roensch J, Joanny JF, Paluch E (2009) Role of cortical tension in bleb growth. Proc Natl Acad Sci USA 106:18581–18586
Tsai MA, Waugh RE, Keng PC (1996) Cell cycle-dependence of HL-60 cell deformability. Biophys J 70:2023–2029
Tsai J-W, Lian W-N, Kemal S, Kriegstein AR, Vallee RB (2010) Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Nat Neurosci 13:1463–1471
Tsou M-FB, Ku W, Hayashi A, Rose LS (2003) PAR-dependent and geometry-dependent mechanisms of spindle positioning. J Cell Biol 160:845–855
Tuomikoski T, Felix M-A, Dorée M, Gruenberg J (1989) Inhibition of endocytic vesicle fusion in vitro by the cell-cycle control protein kinase cdc2. Nature 342:942–945
Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW (2009) Cell growth and size homeostasis in proliferating animal cells. Science 325:167–171
Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, Kumar R (2002) Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 4:681–690
Van Eyk JE, Arrell DK, Foster DB, Strauss JD, Heinonen TYK, Furmaniak-Kazmierczak E, Côté GP, Mak AS (1998) Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle. J Biol Chem 273:23433–23439
Vogel SK, Raabe I, Dereli A, Maghelli N, Tolić-Nørrelykke IM (2007) Interphase microtubules determine the initial alignment of the mitotic spindle. Curr Biol 17:438–444
Walmod PS, Hartmann-Petersen R, Prag S, Lepekhin EL, Röpke C, Berezin V, Bock E (2004) Cell-cycle-dependent regulation of cell motility and determination of the role of Rac1. Exp Cell Res 295:407-420
Wang SW, Hertzler PL, Clark WH Jr (2008) Mesendoderm cells induce oriented cell division and invagination in the marine shrimp Sicyonia ingentis. Dev Biol 320:175–184
Wang YL (2001) The mechanism of cytokinesis: reconsideration and reconciliation. Cell Struct Funct 26:633–638
Wang YL, Taylor DL (1979) Distribution of fluorescently labeled actin in living sea urchin eggs during early development. J Cell Biol 81:672–679
Warren G, Davoust J, Cockcroft A (1984) Recycling of transferrin receptors in A431 cells is inhibited during mitosis. EMBO J 3:2217–2225
Warren SL, Nelson WJ (1987) Nonmitogenic morphoregulatory action of pp 60(v-src) on multicellular epithelial structures. Mol Cell Biol 7:1326–1337
Wei Y, Mikawa T (2000) Formation of the avian primitive streak from spatially restricted blastoderm: evidence for polarized cell division in the elongating streak. Development 127:87–96
Werner M, Glotzer M (2008) Control of cortical contractility during cytokinesis. Biochem Soc Trans 36:371–377
White JG, Borisy GG (1983) On the mechanisms of cytokinesis in animal cells. J Theor Biol 101:289–316
Yamakita Y, Totsukawa G, Yamashiro S, Fry D, Zhang X, Hanks S, Matsumura F (1999) Dissociation of FAK/p130CAS/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK. J Cell Biol 144:315–324
Yamashiro S, Matsumura F (1991) Mitosis-specific phosphorylation of caldesmon: possible molecular mechanism of cell rounding during mitosis. BioEssays 13:563–568
Yamashiro S, Yamakita Y, Ishikawa R, Matsumura F (1990) Mitosis-specific phosphorylation causes 83K non-muscle caldesmon to dissociate from microfilaments. Nature 344:675–678
Yamashiro S, Chern H, Yamakita Y, Matsumura F (2001) Mutant Caldesmon lacking cdc2 phosphorylation sites delays M-phase entry and inhibits cytokinesis. Mol Biol Cell 12:239–250
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998) Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 393:809–812
Yeung A, Evans E (1989) Cortical shell-liquid core model for passive flow of liquid-like spherical cells into micropipets. Biophys J 56:139–149
Zeng Q, Lagunoff D, Masaracchia R, Goeckeler Z, Côté G, Wysolmerski R (2000) Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II. J Cell Sci 113:471–482
Zhao Z, Rivkees SA (2003) Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation. Dev Dyn 226:24–32
Zumdieck A, Kruse K, Bringmann H, Hyman AA, Jülicher F (2007) Stress generation and filament turnover during actin ring constriction. PLoS One 2:e696
Acknowledgments
We thank B. Baum, J.S. Bois, S.W. Grill, C. Norden, and G. Salbreux for their comments on the manuscript, A. Rudnick for assistance with the illustrations, and The Polish Ministry for Science and Higher Education, the Max Planck Society, and the Human Frontier Science Program for financial support.
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Clark, A.G., Paluch, E. (2011). Mechanics and Regulation of Cell Shape During the Cell Cycle. In: Kubiak, J. (eds) Cell Cycle in Development. Results and Problems in Cell Differentiation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19065-0_3
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