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Biological Roles of the STAT Family in Cytokine Signaling

  • Chapter
Book cover Transcription Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 166))

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Abstract

The JAK-STAT pathway, originally identified in the interferon signaling pathway, has been shown to play an essential role in cytokine-mediated biological responses mainly through the analysis of knockout mice. The JAK family consists of four members (Jak1-3 and Tyk2), and the STAT family consists of seven members (Stat1–4, Stat5a, Stat5b, and Stat6). The JAK family of proteins plays an essential role mediated by cytokine receptors, whereas STAT proteins are responsible for their specific cytokines. In addition, there is a considerable body of evidence demonstrating that activity of the JAK-STAT pathway is regulated by several mechanisms, including the sacs family of proteins induced by activation of the JAK-STAT pathway. Gene targeting of the SOCS family revealed that individual sacs proteins negatively regulate some cytokine-mediated signaling pathways.

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  1. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka, 565-0871, Japan

    K. Takeda & S. Akira

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  1. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Strasse 10, 13125, Berlin, Germany

    Manfred Gossen

  2. atugen AG, Robert-Rössle-Strasse 10, 13125, Berlin, Germany

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  3. Department of Biochemistry and Molecular Biology, Michigan State University, 510 Biochemistry Building, East Lansing, MI, 48824-1319, USA

    Steven J. Triezenberg (Associate Director) (Associate Director)

  4. Graduate Program in Cell and Molecular Biology, Michigan State University, 510 Biochemistry Building, East Lansing, MI, 48824-1319, USA

    Steven J. Triezenberg (Associate Director) (Associate Director)

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Takeda, K., Akira, S. (2004). Biological Roles of the STAT Family in Cytokine Signaling. In: Gossen, M., Kaufmann, J., Triezenberg, S.J. (eds) Transcription Factors. Handbook of Experimental Pharmacology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18932-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-18932-6_4

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