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Bone Marrow Infections

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Abstract

Definition. Bone marrow infections are specific and non-specific cytopathological and histopathological changes produced in the hematopoietic tissue by various infectious agents.

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References

  • Abdalla S, Weatherall DJ, Wickramasinghe SN, Hughes M (1980) The anaemia of P. falciparum malaria. Br J Haematol 46:171–183

    Article  PubMed  CAS  Google Scholar 

  • Almeida-Porada GD, Ascensao JL (1996) Cytomegalovirus as a cause of pancytopenia. Leuk Lymphoma 21:217–223

    Article  PubMed  CAS  Google Scholar 

  • Aoyagi K, Ohhara N, Okamura S, Otsuka T, Shibuya T, Yamano Y, Tsuda Y, Niho Y (1987) Aplastic anemia associated with type A viral hepatitis — possible role of T-lymphocytes. Jpn J Med 26:348–532

    Article  PubMed  CAS  Google Scholar 

  • Apperley JF, Goldman JM (1988) Cytomegalovirus: biology, clinical features and methods for diagnosis. Bone Marrow Transplant 3:253–264

    PubMed  CAS  Google Scholar 

  • Ash LR, Orihel TC (eds) (1997) Atlas of Human Parasitology. American Academy of Clinical Pathology, Chicago, IL

    Google Scholar 

  • Bachwich D, Dienstag J (1993) Aplastic anemia and hepatitis C: molecular biology exonerates another suspect. Hepatology 17:340–342

    Article  PubMed  CAS  Google Scholar 

  • Bain BJ (1997) The haematological features of HIV infection [see comments]. Br J Haematol 99:1–8

    Article  PubMed  CAS  Google Scholar 

  • Bakken JS (1998) The discovery of human granulocytotropic ehrlichiosis. J Lab Clin Med 132:175–180

    Article  PubMed  CAS  Google Scholar 

  • Baranski B, Armstrong G, Truman JT, Quinnan GV, Jr, Straus SE, Young NS (1988) Epstein-Barr virus in the bone marrow of patients with aplastic anemia. Ann Intern Med 109:695–704

    PubMed  CAS  Google Scholar 

  • Bayer WL, Sherman FE, Michaels RH, Szeto IL, Lewis JH (1965) Purpura in congenital and acquired rubella. N Engl J Med 273:1362–1366

    Article  PubMed  CAS  Google Scholar 

  • Bhamarapravati N (1989) Hemostatic defects in dengue hemorrhagic fever. Rev Infect Dis 11 Suppl 4:8826–829

    Google Scholar 

  • Bierman H, Nelson E (1965) Hematodepressive virus in Thailand. Ann Intern Med 62:867–884

    PubMed  CAS  Google Scholar 

  • Bogucki MS, August DA, Andriole VT (1990) Clostridial infection of a locally recurrent renal cell carcinoma with sepsis. Cancer 66:601–603

    Article  PubMed  CAS  Google Scholar 

  • Bolger GB, Sullivan KM, Storb R, Witherspoon RP, Weiden PL, Stewart P, Sanders J, Meyers JD, Martin PJ, Doney KC, et al. (1986) Second marrow infusion for poor graft function after allogeneic marrow transplantation. Bone Marrow Transplant 1:21–30

    PubMed  CAS  Google Scholar 

  • Broliden K, Tolfvenstam T, Ohlsson S, Henter JI (1998) Persistent B19 parvovirus infection in pediatrie malignancies. Med Pediatr Oncol 31:66–72

    Article  PubMed  CAS  Google Scholar 

  • Brown KE, Anderson SM, Young NS (1993) Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science 262:114–117

    Article  PubMed  CAS  Google Scholar 

  • Brown KE, Tisdale J, Barrett AJ, Dunbar CE, Young NS (1997) Hepatitis-associated aplastic anemia [see comments]. N Engl J Med 336:1059–1064

    Article  PubMed  CAS  Google Scholar 

  • Buchanan GR (1985) The mild anemia of acute infection. Pediatr Infect Dis 4:225–228

    Article  PubMed  CAS  Google Scholar 

  • Bulvik S, Aronson I, Ress S, Jacobs P (1995) Extensive bone marrow necrosis associated with antiphospholipid antibodies. Am J Med 98:572–574

    Article  PubMed  CAS  Google Scholar 

  • Burkhardt R (1988) Bone marrow in megakaryocytic disorders. Hematol Oncol Clin North Am 2:695–733

    PubMed  CAS  Google Scholar 

  • Camitta BM, Nathan DG, Forman EN, Parkman R, Rappeport JM, Orellana TD (1974) Posthepatitic severe aplastic anemia — an indication for early bone marrow transplantation. Blood 43:473–483

    PubMed  CAS  Google Scholar 

  • Carrigan DR, Knox KK (1994) Human herpesvirus 6 (HHV-6) isolation from bone marrow: HHV-6-associated bone marrow suppression in bone marrow transplant patients [see comments]. Blood 84:3307–3310

    PubMed  CAS  Google Scholar 

  • Casciato DA, Klein CA, Kaplowitz N, Scott JL (1978) Aplastic anemia associated with type B viral hepatitis. Arch Intern Med 138:1557–1558

    Article  PubMed  CAS  Google Scholar 

  • Cassinotti P, Schultze D, Schlageter P, Chevili S, Siegl G (1993) Persistent human parvovirus B19 infection following an acute infection with meningitis in an immunocompetent patient. Eur J Clin Microbiol Infect Dis 12:701–704

    Article  PubMed  CAS  Google Scholar 

  • Chandler F, Watts J (1987) Pathologic Diagnosis of Fungal Infections. ASCP Press, Chicago, IL

    Google Scholar 

  • Chesney PJ, Taher A, Gilbert EM, Shahidi NT (1978) Intranuclear inclusions in megakaryocytes in congenital cytomegalovirus infection. J Pediatr 92:957–958

    Article  PubMed  CAS  Google Scholar 

  • Coffey AJ, Brooksbank RA, Brandau O, Oohashi T, Howell GR, Bye JM, Cahn AP, Durham J, Heath P, Wray P, Pavitt R, Wilkinson J, Leversha M, Huckle E, Shaw-Smith CJ, Dunham A, Rhodes S, Schuster V, Porta G, Yin L, Serafini P, Sylla B, Zoilo M, Franco B, Bentley DR, et al. (1998) Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene [see comments]. Nat Genet 20:129–135

    Article  PubMed  CAS  Google Scholar 

  • Diebold J, Molina T, Camilleri-Broet S, Le Tourneau A, Audouin J (2000) Bone marrow manifestations of infections and systemic diseases observed in bone marrow trephine biopsy review. Histopathology 37:199–211

    Article  PubMed  CAS  Google Scholar 

  • Dominguez A, Gamallo G, Garcia R, Lopez-Pastor A, Pena JM, Vazquez JJ (1994) Pathophysiology of HIV related thrombocytopenia: an analysis of 41 patients. J Clin Pathol 47:999–1003

    Article  PubMed  CAS  Google Scholar 

  • Dumler JS, Brouqui P, Aronson J, Taylor JP, Walker DH (1991) Identification of Ehrlichia in human tissue [letter]. N Engl J Med 325:1109–1110

    Article  PubMed  CAS  Google Scholar 

  • Dumler JS, Dawson JE, Walker DH (1993) Human ehrlichiosis: hematopathology and immunohistologic detection of Ehrlichia chaffeensis. Hum Pathol 24:391–396

    Article  PubMed  CAS  Google Scholar 

  • Ellaurie M, Burns ER, Rubinstein A (1990) Hematologie manifestations in pédiatrie HIV infection: severe anemia as a prognostic factor. Am J Pediatr Hematol Oncol 12:449–453

    Article  PubMed  CAS  Google Scholar 

  • Facer CA, Bray RS, Brown J (1979) Direct Coombs antiglobulin reactions in Gambian children with Plasmodium falciparum malaria. I. Incidence and class specificity. Clin Exp Immunol 35:119–127

    PubMed  CAS  Google Scholar 

  • Ferry JA, Pettit CK, Rosenberg AE, Harris NL (1991) Fungi in megakaryocytes. An unusual manifestation of fungal infection of the bone marrow. Am J Clin Pathol 96:577–581

    PubMed  CAS  Google Scholar 

  • Gascon P, Sathe SS, Rameshwar P (1993) Impaired erythropoiesis in the acquired immunodeficiency syndrome with disseminated Mycobacterium avium complex. Am J Med 94:41–48

    Article  PubMed  CAS  Google Scholar 

  • Gluckman E, Devergie A, Faille A, Bussel A, Benbunan M, Bernard J (1979) Antilymphocyte globulin treatment in severe aplastic anemia — comparison with bone marrow transplantation. Report of 60 cases. Hamatol Bluttransfus 24:171–179

    CAS  Google Scholar 

  • Gombos MM, Bienkowski RS, Gochman RF, Billett HH (1998) The absolute neutrophil count: is it the best indicator for occult bacteremia in infants. Am J Clin Pathol 109:221–225

    PubMed  CAS  Google Scholar 

  • Hadchouel M, Prieur AM, Griscelli C (1985) Acute hemorrhagic, hepatic, and neurologic manifestations in juvenile rheumatoid arthritis: possible relationship to drugs or infection. J Pediatr 106:561–566

    Article  PubMed  CAS  Google Scholar 

  • Herrod HG, Dow LW, Sullivan JL (1983) Persistent epsteinbarr virus infection mimicking juvenile chronic myelogenous leukemia: immunologie and hematologie studies. Blood 61:1098–1104

    PubMed  CAS  Google Scholar 

  • Horsburgh CR, Jr, Caldwell MB, Simonds RJ (1993) Epidemiology of disseminated nontuberculous mycobacterial disease in children with acquired immunodeficiency syndrome. Pediatr Infect Dis J 12:219–222

    Article  PubMed  Google Scholar 

  • Ingram CW, Cooper JN (1989) Clostridial bloodstream infections. South Med J 82:29–31

    Article  PubMed  CAS  Google Scholar 

  • Isomura H, Yoshida M, Namba H, Fujiwara N, Ohuchi R, Uno F, Oda M, Seino Y, Yamada M (2000) Suppressive effects of human herpesvirus-6 on thrombopoietin-inducible megakaryocytic colony formation in vitro. J Gen Virol 81 Pt 3:663–673

    Google Scholar 

  • Jacobs RF, Schütze GE (1997) Ehrlichiosis in children. J Pediatr 131:184–192

    Article  PubMed  CAS  Google Scholar 

  • Jordan A, Penchansky L (1995) Diagnosis of parvovirus Bi9-induced anemia: correlation of bone marrow morphology with molecular diagnosis using PCR and immunohistochemistry. Cell Vision 2:279–282

    CAS  Google Scholar 

  • Kaloutsi V, Kohlmeyer U, Maschek H, Nafe R, Choritz H, Amor A, Georgii A (1994) Comparison of bone marrow and hematologie findings in patients with human immunodeficiency virus infection and those with myelodysplastic syndromes and infectious diseases. Am J Clin Pathol 101:123–129

    PubMed  CAS  Google Scholar 

  • Kaneko Y, Maseki N, Sakurai M, Ido M, Tsunematsu Y, Mizutani S, Hattori T, Shimizu H, Eguchi H, Oka T, et al. (1995) Clonal and non-clonal karyotypically abnormal cells in haemophagocytic lymphohistiocytosis. Br J Haematol 90:48–55

    Article  PubMed  CAS  Google Scholar 

  • Kawaguchi H, Miyashita T, Herbst H, Niedobitek G, Asada M, Tsuchida M, Hanada R, Kinoshita A, Sakurai M, Kobayashi N, et al. (1993) Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome. J Clin Invest 92:1444–1450

    Article  PubMed  CAS  Google Scholar 

  • Keller FG, Kurtzberg J (1994) Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome. Am J Pediatr Hematol Oncol 16:368–371

    PubMed  CAS  Google Scholar 

  • Kikuta H (1995) Epstein-Barr virus-associated hemophagocytic syndrome. Leuk Lymphoma 16:425–429

    Article  PubMed  CAS  Google Scholar 

  • Koeppen H, Newell K, Baunoch DA, Vardiman JW (1998) Morphologie bone marrow changes in patients with posttransplantation lymphoproliferative disorders. Am J Surg Pathol 22:208–214

    Article  PubMed  CAS  Google Scholar 

  • Korppi M, Kroger L, Laitinen M (1993) White blood cell and differential counts in acute respiratory viral and bacterial infections in children. Scand J Infect Dis 25:435–440

    Article  PubMed  CAS  Google Scholar 

  • Kosugi S, Imai Y, Kurata Y, Tomiyama Y, Shiraga M, Honda S, Nishikawa M, Yonezawa T, Kanakura Y, Matsuzawa Y (1997) Platelet-associated IgM elevated in patients with chronic hepatitis C contains no anti-platelet autoantibodies. Liver 17:230–237

    PubMed  CAS  Google Scholar 

  • Kreuzer KA, Rockstroh JK (1997) Pathogenesis and pathophysiology of anemia in HIV infection. Ann Hematol 75:179–187

    Article  PubMed  CAS  Google Scholar 

  • Kuppermann N, Walton EA (1999) Immature neutrophils in the blood smears of young febrile children. Arch Pediatr Adolesc Med 153:261–266

    PubMed  CAS  Google Scholar 

  • Kurtin PJ, McKinsey DS, Gupta MR, Driks M (1990) Histoplasmosis in patients with acquired immunodeficiency syndrome. Hématologie and bone marrow manifestations. Am J Clin Pathol 93:367–372

    PubMed  CAS  Google Scholar 

  • Kurtzhals JA, Rodrigues O, Addae M, Commey JO, Nkrumah FK, Hviid L (1997) Reversible suppression of bone marrow response to erythropoietin in Plasmodium falciparum malaria. Br J Haematol 97:169–174

    Article  PubMed  CAS  Google Scholar 

  • Landesman SH, Kalish LA, Burns DN, Minkoff H, Fox HE, Zorrilla C, Garcia P, Fowler MG, Mofenson L, Tuomala R (1996) Obstetrical factors and the transmission of human immunodeficiency virus type 1 from mother to child. The Women and Infants Transmission Study [see comments]. N Engl J Med 334:1617–1623

    Article  PubMed  CAS  Google Scholar 

  • Lazarus KH, Baehner RL (1981) Aplastic anemia complicating infectious mononucleosis: a case report and review of the literature. Pediatrics 67:907–910

    PubMed  CAS  Google Scholar 

  • Lisse IM, Aaby P, Whittle H, Knudsen K (1994) A community study of T lymphocyte subsets and malaria parasitaemia. Trans R Soc Trop Med Hyg 88:709–710

    Article  PubMed  CAS  Google Scholar 

  • Liu W, Ittmann M, Liu J, Schoentag R, Tierno P, Greco MA, Sidhu G, Nierodzik M, Wieczorek R (1997) Human parvovirus B19 in bone marrows from adults with acquired immunodeficiency syndrome: a comparative study using in situ hybridization and immunohistochemistry. Hum Pathol 28:760–766

    Article  PubMed  CAS  Google Scholar 

  • Mandell G (1985) Principles and Practice of Infectious Diseases, 2nd edn. Wiley, New York

    Google Scholar 

  • McDade JE (1990) Ehrlichiosis — a disease of animals and humans. J Infect Dis 161:609–617

    Article  PubMed  CAS  Google Scholar 

  • Miller LH, Good MF, Milon G (1994) Malaria pathogenesis. Science 264:1878–1883

    Article  PubMed  CAS  Google Scholar 

  • Miranda-Novales MG, Solorzano-Santos F, Diaz-Ponce H, Ruiz-Rodriguez A, Cabrera-Munoz L (1993) [Disseminated histoplasmosis in pediatrics. Report of a case]. Bol Med Hosp Infant Mex 50:272–275

    PubMed  CAS  Google Scholar 

  • Morey AL, O’Neill HJ, Coyle PV, Fleming KA (1992) Immunohistological detection of human parvovirus B19 in formalin-fixed, paraffin-embedded tissues. J Pathol 166:105–108

    Article  PubMed  CAS  Google Scholar 

  • Moriyama K, Okamura T, Nakano S (1997) Hepatitis GB virus C genome in the serum of aplastic anaemia patients receiving frequent blood transfusions [see comments]. Br J Haematol 96:864–867

    Article  PubMed  CAS  Google Scholar 

  • Mueller BU, Tannenbaum S, Pizzo PA (1996) Bone marrow aspirates and biopsies in children with human immunodeficiency virus infection. J Pediatr Hematol Oncol 18:266–271

    Article  PubMed  CAS  Google Scholar 

  • Nagamine T, Ohtuka T, Takehara K, Arai T, Takagi H, Mori M (1996) Thrombocytopenia associated with hepatitis C viral infection [see comments]. J Hepatol 24:135–140

    Article  PubMed  CAS  Google Scholar 

  • Nair JM, Bellevue R, Bertoni M, Dosik H (1988) Thrombotic thrombocytopenic purpura in patients with the acquired immunodeficiency syndrome (AIDS)-related complex. A report of two cases. Ann Intern Med 109:209–212

    PubMed  CAS  Google Scholar 

  • Neame PB, Kelton JG, Walker IR, Stewart IO, Nossel HL, Hirsh J (1980) Thrombocytopenia in septicemia: the role of disseminated intravascular coagulation. Blood 56:88–92

    PubMed  CAS  Google Scholar 

  • Nelson E, Bierman H, Chulajara R (1964) Hématologie findings in the i960 hemorrhagic fever epidemic (dengue) in Thailand. Am J Trop Med Hyg 12:642–649Onorato J, Esposito S, Scovena E, Morandi B, Morelli M, Pizzi M, Zisa G, Marchisio P, Principi N (1999) Eosinophil involvement and serum IgE level in HIV-i-infected children. J Allergy Clin Immunol 104:245-247

    Google Scholar 

  • Pappolla MA, Mehta VT (1984) PAS reaction stains phagocytosed atypical mycobacteria in paraffin sections. Arch Pathol Lab Med 108:372–373

    PubMed  CAS  Google Scholar 

  • Pattison JR, Jones SE, Hodgson J, Davis LR, White JM, Stroud CE, Murtaza L (1981) Parvovirus infections and hypoplastic crisis in sickle-cell anaemia [letter]. Lancet 1:664–665

    Article  PubMed  CAS  Google Scholar 

  • Penchansky L, Jordan JA (1997) Transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant B. Am J Clin Pathol 108:127–132

    PubMed  CAS  Google Scholar 

  • Penchansky L, Krause JR (1979) Identification of cytomegalovirus in bone marrow biopsy. South Med J 72:500–501

    Article  PubMed  CAS  Google Scholar 

  • Risdall RJ, McKenna RW, Nesbit ME, Krivit W, Balfour HH, Jr, Simmons RL, Brunning RD (1979) Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. Cancer 44:993–1002

    Article  PubMed  CAS  Google Scholar 

  • Rosenfeld CS, Rybka WB, Weinbaum D, Carrigan DR, Knox KK, Andrews DF, Shadduck RK (1995) Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus-6. Exp Hematol 23:626–629

    PubMed  CAS  Google Scholar 

  • Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B, et al. (1986) Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596–601

    Article  PubMed  CAS  Google Scholar 

  • Samuels P, Bussel JB, Braitman LE, Tomaski A, Druzin ML, Mennuti MT, Cines DB (1990) Estimation of the risk of thrombocytopenia in the offspring of pregnant women with presumed immune thrombocytopenic purpura [see comments]. N Engl J Med 323:229–235

    Article  PubMed  CAS  Google Scholar 

  • Sandhaus LM, Scudder R (1989) Hématologie and bone marrow abnormalities in pédiatrie patients with human immunodeficiency virus (HIV) infection. Pediatr Pathol 9:277–288

    Article  PubMed  CAS  Google Scholar 

  • Santoro F, Kennedy PE, Locatelli G, Malnati MS, Berger EA, Lusso P (1999) CD46 is a cellular receptor for human herpesvirus 6. Cell 99:817–827

    Article  PubMed  CAS  Google Scholar 

  • Simmons P, Kaushansky K, Torok-Storb B (1990) Mechanisms of cytomegalovirus-mediated myelosuppression: perturbation of stromal cell function versus direct infection of myeloid cells. Proc Nati Acad Sei U S A 87:1386–1390

    Article  CAS  Google Scholar 

  • Slagel DD, Lager DJ, Dick FR (1994) Howell-Jolly body-like inclusions in the neutrophils of patients with acquired immunodeficiency syndrome [see comments]. Am J Clin Pathol 101:429–431

    PubMed  CAS  Google Scholar 

  • Stephan JL, Zeller J, Hubert P, Herbelin C, Dayer JM, Prieur AM (1993) Macrophage activation syndrome and rheumatic disease in childhood: a report of four new cases. Clin Exp Rheumatol 11:451–456

    PubMed  CAS  Google Scholar 

  • Sumaya CV, Ench Y (1985) Epstein-Barr virus infectious mononucleosis in children. II. Heterophil antibody and viral-specific responses. Pediatrics 75:1011–1019

    PubMed  CAS  Google Scholar 

  • Tzakis AG, Arditi M, Whitington PF, Yanaga K, Esquivel C, Andrews WA, Makowka L, Malatak J, Freese DK, Stock PG, et al. (1988) Aplastic anemia complicating orthotopic liver transplantation for non-A, non-B hepatitis. N Engl J Med 319:393–396

    Article  PubMed  CAS  Google Scholar 

  • Verdonck L, de Gast G, van Heugten H, Nieuwenhuis H, Dekker A (1991) Cytomegalovirus infection causes delayed platelet recovery after bone marrow transplantation. (Clinical Trial. Journal Article). Blood 78:844–848

    PubMed  CAS  Google Scholar 

  • Woodroff A, Andsell V, Pettitt L (1979) Causes of anaemia in malaria. Lancet 1:1055–1057

    Article  Google Scholar 

  • Young NS, Alter BP (1994) Aplastic Anemia Acquired and Inherited. WB Saunders, Philadelphia, PA, chap 8

    Google Scholar 

  • Zinkham WH, Medearis DN, Jr, Osborn JE (1967) Blood and bone-marrow findings in congenital rubella. J Pediatr 71:512–524

    Article  PubMed  CAS  Google Scholar 

  • Zoumbos NC, Ferris WO, Hsu SM, Goodman S, Griffith P, Sharrow SO, Humphries RK, Nienhuis AW, Young N (1984) Analysis of lymphocyte subsets in patients with aplastic anaemia. Br J Haematol 58:95–105

    Article  PubMed  CAS  Google Scholar 

  • Zoumbos NC, Gascon P, Djeu JY, Trost SR, Young NS (1985) Circulating activated suppressor T lymphocytes in aplastic anemia. N Engl J Med 312:257–265

    Article  PubMed  CAS  Google Scholar 

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Penchansky, L. (2004). Bone Marrow Infections. In: Pediatric Bone Marrow. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18799-5_4

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