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Neuropeptide Y and Related Peptides pp 221–249Cite as

NPY: A Novel On/Off Switch for Control of Appetite and Reproduction

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 162))

Abstract

The information collated here supports the concept that neuropeptide Y (NPY) is an essential messenger molecule in integration of the innate appetitive drive and the urge to reproduce. There is a spatial and temporal specificity of NPY action in the hypothalamus wherein two distinct NPY pathways receive and transduce external and internal environmental information to sustain nutritional homeostasis and reproductive functions. A distinct subset of NPY expressing neurons serves as the on/off switch to stimulate appetite but inhibit reproduction when unfavorable nutritional environments and hormonal, neural, metabolic and genetic disturbances persist. This capability of NPYergic signaling to reciprocally modify the two instinctual urges with the aid of distinct NPY receptor subtypes and intricate connectivities with varied peptidergic pathways, and with the cooperation of chemically diverse coexpressed neurotransmitters, has uncovered multiple loci vulnerable to therapeutic interventions to treat eating disorders and obesity without adversely affecting fertility.

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References

  • Ahima RS, Saper CB, Flier JS, Elmquist JK (2000) Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21:263–307

    PubMed  CAS  Google Scholar 

  • Allen LG, Crowley WR, Kalra SP (1987) Interactions between neuropeptide Y and adrenergic systems in the stimulation of luteinizing hormone release in steroid-primed ovariectomized rats. Endocrinology 121:1953–1959

    PubMed  CAS  Google Scholar 

  • Allen LG, Kalra PS, Crowley WR, Kalra SP (1985) Comparison of the effects of neuropeptide Y and adrenergic transmitters on LH release and food intake in male rats. Life Sci 37:617–623

    PubMed  CAS  Google Scholar 

  • Allen LG, Kalra SP (1986) Evidence that a decrease in opioid tone may evoke preovulatory luteinizing hormone release in the rat. Endocrinology 118:2375–2381

    PubMed  CAS  Google Scholar 

  • Bagnasco M, Dube MG, Kalra PS, Kalra SP (2002a) Evidence for the existence of distinct central appetite and energy expenditure pathways and stimulation of ghrelin as revealed by hypothalamic site-specific leptin gene therapy. Endocrinology 143:4409–4421

    PubMed  CAS  Google Scholar 

  • Bagnasco M, Kalra PS, Kalra SP (2002b) Ghrelin and leptin pulse discharge in fed and fasted rats. Endocrinology 143:726–729.

    PubMed  CAS  Google Scholar 

  • Bagnasco M, Kalra PS, Kalra SP (2002c) Plasma leptin levels are pulsatile in adult rats: effects of gonadectomy. Neuroendocrinology 75:257–263.

    PubMed  CAS  Google Scholar 

  • Bai FL, Yamano M, Shiotani Y, Emson PC, Smith AD, Powell JF, Tohyama M (1985) An arcuato-paraventricular and-dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res 331:172–175

    PubMed  CAS  Google Scholar 

  • Balasubramaniam AA (1997) Neuropeptide Y family of hormones: receptor subtypes and antagonists. Peptides 18:445–457

    PubMed  CAS  Google Scholar 

  • Bannon AW, Seda J, Carmouche M, Francis JM, Norman MH, Karbon B, McCaleb ML (2000) Behavioral characterization of neuropeptide Y knockout mice. Brain Res 868:79–87

    PubMed  CAS  Google Scholar 

  • Bauer-Dantoin AC, McDonald JK, Levine JE (1992) Neuropeptide Y potentiates luteinizing hormone (LH)-releasing hormone-induced LH secretion only under conditions leading to preovulatory LH surges. Endocrinology 131:2946–2952

    PubMed  CAS  Google Scholar 

  • Beretta E, Dube MG, Kalra PS, Kalra SP (2002) Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: Effects on serum ghrelin and appetite-regulating genes. Pediatr Res 52:189–198

    PubMed  CAS  Google Scholar 

  • Bergendahl M, Veldhuis JD (1995) Altered pulsatile gonadotropin signaling in nutiritional efficieny in the male. Trends Endocrinol Metab 6:145–159

    PubMed  CAS  Google Scholar 

  • Billington CJ, Briggs JE, Harker S, Grace M, Levine AS (1994) Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am J Physiol 266: R1765–R1770

    PubMed  CAS  Google Scholar 

  • Bonavera J J, Dube MG, Kalra PS, Kalra SP (1994a) Anorectic effects of estrogen may be mediated by decreased neuropeptide-Y release in the hypothalamic paraventricular nucleus. Endocrinology 134:2367–2370

    PubMed  CAS  Google Scholar 

  • Bonavera JJ, Sahu A, Kalra PS, Kalra SP (1993) Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: involvement of excitatory amino acids. Endocrinology 133:2481–2487

    PubMed  CAS  Google Scholar 

  • Bonavera JJ, Sahu A, Kalra PS, Kalra SP (1994b) Evidence in support of nitric oxide (NO) involvement in the cyclic release of prolactin and LH surges. Brain Res 660:175–179

    PubMed  CAS  Google Scholar 

  • Bray GA (1984) Syndromes of hypothalamic obesity in man. Pediatr Ann 13:525–536

    PubMed  CAS  Google Scholar 

  • Bray GA (1998) Historical framework for the development of ideas about obesity. In: Bray GA, Bouchard C, James WPT (eds) Handbook of obesity, vol 1. New York, Marcel Dekker, pp 1–29

    Google Scholar 

  • Broberger C, Hokfelt T (2001) Hypothalamic and vagal neuropeptide circuitries regulating food intake. Physiol Behav 74:669–682

    PubMed  CAS  Google Scholar 

  • Broberger C, Landry M, Wong H, Walsh JN, Hokfelt T (1997) Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin-and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 66:393–408

    PubMed  CAS  Google Scholar 

  • Campbell RE, Ffrench-Mullen JM, Cowley MA, Smith MS, Grove KL (2001) Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype. Neuroendocrinology 74:106–119

    PubMed  CAS  Google Scholar 

  • Campbell RE, Smith MS, Allen SE, Grayson BE, French-Mullen JM, Grove KL (2003) Orexin neurons express a functional pancreatic polypeptide Y4 receptor. J Neurosci 23:1487–1497

    PubMed  CAS  Google Scholar 

  • Caprio M, Fabbrini E, Isidori AM, Aversa A, Fabbri A (2001) Leptin in reproduction. Trends Endocrinol Metab 12:65–72

    PubMed  CAS  Google Scholar 

  • Catzeflis C, Pierroz DD, Rohner-Jeanrenaud F, Rivier JE, Sizonenko PC, Aubert ML (1993) Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats. Endocrinology 132:224–234

    PubMed  CAS  Google Scholar 

  • Chaffer CL, Morris MJ (2002) The feeding response to melanin-concentrating hormone is attenuated by antagonism of the NPY Y(1)-receptor in the rat. Endocrinology 143:191–197

    PubMed  CAS  Google Scholar 

  • Chehab FF (1997) The reproductive side of leptin. Nature Med 3:952–953

    PubMed  CAS  Google Scholar 

  • Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, Maclntyre DE, Chen HY, Van Der Ploeg LH (2000) Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nature Genet 26:97–102

    PubMed  CAS  Google Scholar 

  • Chen XM, Hosono T, Yoda T, Fukuda Y, Kanosue K (1998) Efferent projection from the preoptic area for the control of non-shivering thermogenesis in rats. J Physiol 512:883–892

    PubMed  CAS  Google Scholar 

  • Cheung CC, Clifton DK, Steiner RA (2000) Perspectives on leptin’s role as a metabolic signal for the onset of puberty. Front Horm Res. 26:87–105

    PubMed  CAS  Google Scholar 

  • Choi S, Sparks R, Clay M, Dallman MF (1999) Rats with hypothalamic obesity are insensitive to central leptin injections. Endocrinology 140:4426–4433

    PubMed  CAS  Google Scholar 

  • Chronwall BB (1988) Anatomical distribution of NPY and NPY messenger RNA in the brain. In: Mutt V, Fuxe K, Hokfelt T, Lundberg JD (eds) Neuropeptide Y. New York, Raven Press, pp 51–60

    Google Scholar 

  • Clark JT, Gist RS, Kalra SP, Kalra PS (1988) Alpha 2-adrenoceptor blockade attenuates feeding behavior induced by neuropeptide Y and epinephrine. Physiol Behav 43:417–422

    PubMed  CAS  Google Scholar 

  • Clark JT, Kalra PS, Crowley WR, Kalra SP (1984) Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115:427–429

    PubMed  CAS  Google Scholar 

  • Clark JT, Kalra PS, Kalra SP (1985) Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats. Endocrinology 117:2435–2442

    PubMed  CAS  Google Scholar 

  • Clark JT, Kalra SP, Kalra PS (1987a) Effects of a selective alpha 1-adrenoceptor agonist, methoxamine, on sexual behavior and penile reflexes. Physiol Behav 40:747–753

    PubMed  CAS  Google Scholar 

  • Clark JT, Sahu A, Kalra PS, Balasubramaniam A, Kalra SP (1987b) Neuropeptide Y (NPY)-induced feeding behavior in female rats: comparison with human NPY ([Metl7]NPY), NPY analog ([norLeu4]NPY) and peptide YY. Regul Pept 17:31–39

    PubMed  CAS  Google Scholar 

  • Corp ES, Greco B, Powers JB, Bivens CL, Wade GN (2001) Neuropeptide Y inhibits estrous behavior and stimulates feeding via separate receptors in Syrian hamsters. Am J Physiol Regul Integr Comp Physiol 280: R1061–R1068.

    PubMed  CAS  Google Scholar 

  • Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD (1999) Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24:155–163

    PubMed  CAS  Google Scholar 

  • Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, Low MJ (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480–484

    PubMed  CAS  Google Scholar 

  • Crowley WR (1999) Toward Multifactorial Hypothalamic Regulation of Anterior Pituitary Hormone Secretion. News Physiol Sci 14:54–58

    PubMed  CAS  Google Scholar 

  • Crowley WR, Hassid A, Kalra SP (1987) Neuropeptide Y enhances the release of luteinizing hormone (LH) induced by LH-releasing hormone. Endocrinology 120:941–945

    PubMed  CAS  Google Scholar 

  • Crowley WR, Kalra SP (1987) Neuropeptide Y stimulates the release of luteinizing hormone-releasing hormone from medial basal hypothalamus in vitro: modulation by ovarian hormones. Neuroendocrinology 46:97–103

    PubMed  CAS  Google Scholar 

  • Crowley WR, Kalra SP (1988) Regulation of luteinizing hormone secretion by neuropeptide Y in rats: hypothalamic and pituitary actions. Synapse 2:276–281

    PubMed  CAS  Google Scholar 

  • Crowley WR, Ramoz G, Hurst B (2003) Evidence for involvement of neuropeptide Y and melanocortin systems in the hyperphagia of lactation in rats. Pharmacol Biochem Behav 74:417–424

    PubMed  CAS  Google Scholar 

  • Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714–1719

    PubMed  CAS  Google Scholar 

  • Daniels AJ, Grizzle MK, Wiard RP, Matthews JE, Heyer D (2002) Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept 106:47–54

    PubMed  CAS  Google Scholar 

  • Daniels AJ, Matthews JE, Slepetis RJ, Jansen M, Viveros OH, Tadepalli A, Harrington W, Heyer D, Landavazo A, Leban JJ, Spaltenstein A (1995) High-affinity neuropeptide Y receptor antagonists. Proc Natl Acad Sci USA 92:9067–9071

    PubMed  CAS  Google Scholar 

  • Dhillon H, Kalra SP, Kalra PS (2001a) Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus. Mol Ther 4:139–145

    PubMed  CAS  Google Scholar 

  • Dhillon H, Kalra SP, Prima V, Zolotukhin S, Scarpace PJ, Moldawer LL, Muzyczka N, Kalra PS (2001b) Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study. Regul Pept 99:69–77

    PubMed  CAS  Google Scholar 

  • Diano S, Kalra SP, Sakamoto H, Horvath TL (1998) Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus. Brain Res 812:256–259

    PubMed  CAS  Google Scholar 

  • Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS, Kalra SP (2002) Central leptin gene therapy blocks high fat diet-induced weight gain, hyperleptinemia and hyperinsulinemia: effects on serum ghrelin levels. Diabetes 51:1729–1736

    PubMed  CAS  Google Scholar 

  • Dube MG, Horvath TL, Kalra PS, Kalra SP (2000a) Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides 21:1557–1560

    PubMed  CAS  Google Scholar 

  • Dube MG, Kalra PS, Crowley WR, Kalra SP (1995) Evidence of a physiological role for neuropeptide Y in ventromedial hypothalamic lesion-induced hyperphagia. Brain Res 690:275–278

    PubMed  CAS  Google Scholar 

  • Dube MG, Kalra SP, Kalra PS (1999a) Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res 842:473–477

    PubMed  CAS  Google Scholar 

  • Dube MG, Pu S, Kalra SP, Kalra PS (2000b) Melanocortin signaling is decreased during neurotoxin-induced transient hyperphagia and increased body-weight gain. Peptides 21:793–801

    PubMed  CAS  Google Scholar 

  • Dube MG, Sahu A, Kalra PS, Kalra SP (1992) Neuropeptide Y release is elevated from the microdissected paraventricular nucleus of food-deprived rats: an in vitro study. Endocrinology 131:684–688

    PubMed  CAS  Google Scholar 

  • Dube MG, Xu B, Crowley WR, Kalra PS, Kalra SP (1994) Evidence that neuropeptide Y is a physiological signal for normal food intake. Brain Res 646:341–344

    PubMed  CAS  Google Scholar 

  • Dube MG, Xu B, Kalra PS, Sninsky CA, Kalra SP (1999b) Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats. Brain Res 816:38–46

    PubMed  CAS  Google Scholar 

  • Dumont T, Jacques D, St. Pierre JA, Quirion R (1997) Neuropeptide Y receptor types in the mammalian brain: species differences and status in the human central nervous system. In: Grundermar L, Bloom S (eds) Neuropeptide Y and drug development. Academic Press, New York, pp 57–86

    Google Scholar 

  • El Majdoubi M, Sahu A, Ramaswamy S, Plant TM (2000) Neuropeptide Y: A hypothalamic brake restraining the onset of puberty in primates. Proc Natl Acad Sci USA 97:6179–6184

    PubMed  CAS  Google Scholar 

  • Erickson JC, Hollopeter G, Palmiter RD (1996) Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274:1704–1707

    PubMed  CAS  Google Scholar 

  • Everitt BJ, Hokfelt T (1989) The coexistence of neuropeptide Y with other peptides and amines in the central nervous system. In: Mutt V, Fuxe K, Hokfelt T, Lundberg J (eds) Neuropeptide Y. New York, Raven Press, pp 61–72

    Google Scholar 

  • Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395:763–770

    PubMed  CAS  Google Scholar 

  • Fuxe K, Tinner B, Caberlotto L, Bunnemann B, Agnati LF (1997) NPY Y1 receptor like immunoreactivity exists in a subpopulation of beta-endorphin immunoreactive nerve cells in the arcuate nucleus: a double immunolabelling analysis in the rat. Neurosci Lett 225:49–52

    PubMed  CAS  Google Scholar 

  • Hahn TM, Breininger JF, Baskin DG, Schwartz MW (1998) Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nature Neurosci 1:271–272

    PubMed  CAS  Google Scholar 

  • Hokfelt T, Broberger C, Xu ZQ, Sergeyev V, Ubink R, Diez M (2000) Neuropeptides—an overview. Neuropharmacology 39:1337–1356

    PubMed  CAS  Google Scholar 

  • Hokfelt T, Broberger C, Zhang X, Diez M, Kopp J, Xu Z, Landry M, Bao L, Schalling M, Koistinaho J, DeArmond SJ, Prusiner S, Gong J, Walsh JH (1998) Neuropeptide Y: some viewpoints on a multifaceted peptide in the normal and diseased nervous system. Brain Res Brain Res Rev 26:154–166

    PubMed  CAS  Google Scholar 

  • Hollopeter G, Erickson JC, Seeley RJ, Marsh DJ, Palmiter RD (1998) Response of neuropeptide Y-deficient mice to feeding effectors. Regul Pept 75/76:383–389

    Google Scholar 

  • Horvath TL, Bechmann I, Naftolin F, Kalra SP, Leranth C (1997) Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res 756:283–286

    PubMed  CAS  Google Scholar 

  • Horvath TL, Diano S, Sotonyi P, Heiman M, Tschop M (2001a) Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology 142:4163–4169

    PubMed  CAS  Google Scholar 

  • Horvath TL, Diano S, van den Pol AN (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 19:1072–1087

    PubMed  CAS  Google Scholar 

  • Horvath TL, Diano S, van den Pol AN (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 19:1072–1087

    PubMed  CAS  Google Scholar 

  • Horvath TL, Kalra SP, Naftolin F, Leranth C (1995) Morphological evidence for a galaninopiate interaction in the rat mediobasal hypothalamus. J Neuroendocrinol 7:579–588

    PubMed  CAS  Google Scholar 

  • Horvath TL, Naftolin F, Kalra SP, Leranth C (1992a) Neuropeptide-Y innervation of betaendorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis. Endocrinology 131:2461–2467

    PubMed  CAS  Google Scholar 

  • Horvath TL, Naftolin F, Leranth C (1992b) GABAergic and catecholaminergic innervation of mediobasal hypothalamic beta-endorphin cells projecting to the medial preoptic area. Neuroscience 51:391–399

    PubMed  CAS  Google Scholar 

  • Horvath TL, Naftolin F, Leranth C, Sahu A, Kalra SP (1996) Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Endocrinology 137:3069–3078

    PubMed  CAS  Google Scholar 

  • Horvath TL, Pu S, Dube MG, Diano S, Kalra SP (2001b) A GABA-neuropeptide Y (NPY) interplay in LH release. Peptides 22:473–481

    PubMed  CAS  Google Scholar 

  • Inui A (1999) Neuropeptide Y feeding receptors: Are multiple subtypes involved? Trends Pharmacol Sci 20:43–46

    PubMed  CAS  Google Scholar 

  • Inui A (2000) Transgenic approach to the study of body weight regulation. Pharmacol Rev 52:35–61

    PubMed  CAS  Google Scholar 

  • Jain MR, Dube MG, Kalra SP, Kalra PS (1998) Neuropeptide Y release in the paraventricular nucleus is decreased during transient hyperphagia induced by microinjection of colchicine into the ventromedial nucleus of rats. Neurosci Lett 256:21–24

    PubMed  CAS  Google Scholar 

  • Jain MR, Horvath TL, Kalra PS, Kalra SP (2000) Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regul Pept 87:19–24

    PubMed  CAS  Google Scholar 

  • Jain MR, Pu S, Kalra PS, Kalra SP (1999) Evidence that stimulation of two modalities of pituitary luteinizing hormone release in ovarian steroid-primed ovariectomized rats may involve neuropeptide Y Y1 and Y4 receptors. Endocrinology 140:5171–5177

    PubMed  CAS  Google Scholar 

  • Kalra PS, Bonavera JJ, Kalra SP (1995a) Central administration of antisense oligodeoxynucleotides to neuropeptide Y (NPY) mRNA reveals the critical role of newly synthesized NPY in regulation of LHRH release. Regul Pept 59:215–220

    PubMed  CAS  Google Scholar 

  • Kalra PS, Dube MG, Kalra SP (2000a) Effects of centrally administered antisense oligodeoxynucleotides on feeding behavior and hormone secretion. Methods Enzymol 314:184–200

    PubMed  CAS  Google Scholar 

  • Kalra PS, Dube MG, Xu B, Farmerie WG, Kalra SP (1998a) Evidence that dark-phase hyperphagia induced by neurotoxin 6-hydroxydopamine may be due to decreased leptin and increased neuropeptide Y signaling. Physiol Behav 63:829–835

    PubMed  CAS  Google Scholar 

  • Kalra PS, Dube MG, Xu B, Farmerie WG, Kalra SP (1998b) Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain: evidence for a hypothalamic site for concurrent development of leptin resistance. J Neuroendocrinol 10:43–49

    PubMed  CAS  Google Scholar 

  • Kalra PS, Dube MG, Xu B, Kalra SP (1997a) Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain. Regul Pept 72:121–130

    PubMed  CAS  Google Scholar 

  • Kalra PS, Kalra SP (2002) Obesity and metabolic syndrome: long-term benefits of central leptin gene therapy. In: Prous JR (ed) Drugs of Today. Barcelona, Prous Science 38:745–757

    Google Scholar 

  • Kalra PS, Norlin M, Kalra SP (1995b) Neuropeptide Y stimulates beta-endorphin release in the basal hypothalamus: role of gonadal steroids. Brain Res 705:353–356

    PubMed  CAS  Google Scholar 

  • Kalra PS, Pu S, Edwards TG, Dube MG (1998c) Hypothalamic galanin is upregulated during hyperphagia. Ann N Y Acad Sci 863:432–434

    PubMed  CAS  Google Scholar 

  • Kalra S (1996) Is neuropeptide Ya naturally occuring appetite transducer? Curr Opin Endocrinol Diabetes 3:157–163

    CAS  Google Scholar 

  • Kalra SP (1993) Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endocrinol Rev 14:507–538

    CAS  Google Scholar 

  • Kalra SP (1997) Appetite and body weight regulation: is it all in the brain? Neuron 19:227–230

    PubMed  CAS  Google Scholar 

  • Kalra SP (2001) Circumventing leptin resistance for weight control. Proc Natl Acad Sci USA 98:4279–4281

    PubMed  CAS  Google Scholar 

  • Kalra SP, Bagnasco M, Otukonyong EE, Dube MG, Kalra PS (2003) Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul Pept 111:1–11.

    PubMed  CAS  Google Scholar 

  • Kalra SP, Clark JT, Sahu A, Dube MG, Kalra PS (1988a) Control of feeding and sexual behaviors by neuropeptide Y: physiological implications. Synapse 2:254–257

    PubMed  CAS  Google Scholar 

  • Kalra SP, Clark JT, Sahu A, Kalra PS, Crowley WR (1989) Hypothalamic NPY: A local circuit is the control of reproduction and behavior. In: Hokfelt T, Lundberg JD, Mutt V, Fuxe K (eds) Neuropeptide Y. New York, Raven Press, pp 229–242

    Google Scholar 

  • Kalra SP, Crowley WR (1984a) Differential effects of pancreatic polypeptide on luteinizing hormone release in female rats. Neuroendocrinology 38:511–513

    PubMed  CAS  Google Scholar 

  • Kalra SP, Crowley WR (1984b) Norepinephrine-like effects of neuropeptide Y on LH release in the rat. Life Sci 35:1173–1176

    PubMed  CAS  Google Scholar 

  • Kalra SP, Dube MG, Fournier A, Kalra PS (1991a) Structure-function analysis of stimulation of food intake by neuropeptide Y: effects of receptor agonists. Physiol Behav 50:5–9

    PubMed  CAS  Google Scholar 

  • Kalra SP, Dube MG, Kalra PS (1988b) Continuous intraventricular infusion of neuropeptide Y evokes episodic food intake in satiated female rats: effects of adrenalectomy and cholecystokinin. Peptides 9:723–728

    PubMed  CAS  Google Scholar 

  • Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS (1999) Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrinol Rev 20:68–100

    CAS  Google Scholar 

  • Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS (1991b) Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA 88:10931–10935

    PubMed  CAS  Google Scholar 

  • Kalra SP, Fuentes M, Fournier A, Parker SL, Crowley WR (1992) Involvement of the Y-1 receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats. Endocrinology 130:3323–3330

    PubMed  CAS  Google Scholar 

  • Kalra SP, Horvath T, Naftolin F, Xu B, Pu S, Kalra PS (1997b) The interactive language of the hypothalamus for the gonadotropin releasing hormone (GNRH) system. J Neuroendocrinol 9:569–576

    PubMed  CAS  Google Scholar 

  • Kalra SP, Horvath TL (1998) Neuroendocrine interactions between galanin, opioids, and neuropeptide Y in the control of reproduction and appetite. Ann N Y Acad Sci 863:236–240

    PubMed  CAS  Google Scholar 

  • Kalra SP, Kalra PS (1983) Neural regulation of luteinizing hormone secretion in the rat. Endocrinol Rev 4:311–351

    CAS  Google Scholar 

  • Kalra SP, Kalra PS (1984) Opioid-adrenergic-steroid connection in regulation of luteinizing hormone secretion in the rat. Neuroendocrinology 38:418–426

    PubMed  CAS  Google Scholar 

  • Kalra SP, Kalra PS (1990) Neuropeptide Y: A novel peptidergic signal for the control of feeding behavior. In: Pfaff DW, Ganten D (eds) Current topics in neuroendocrinology, vol 10. Berlin, Springer-Verlag, pp 192–197

    Google Scholar 

  • Kalra SP, Kalra PS (1996) Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network. Front Neuroendocrinol 17:371–401

    PubMed  CAS  Google Scholar 

  • Kalra SP, Kalra PS (2003) Neuropeptide Y. In: Henry HL, Norman AW (eds) Encyclopedia of hormones, vol 3. San Diego, Academic Press, pp 37–45

    Google Scholar 

  • Kalra SP, Pu S, Horvath TL, Kalra PS (2000b) Leptin and NPY regulation of GnRH secretion and energy homeostasis. In: Bourguignon J, Pap TM (eds) The onset of puberty in perspective. Amsterdam, Elsevier Science, pp 317–327

    Google Scholar 

  • Kalra SP, Sahu A, Dube MG, Bonavera JJ, Kalra PS (1996a) Neuropeptide Y and its neural conections in the etiology of obesity and associated neuroendocrine and behavioral disorders. In: Bray GA, Ryan DH (eds) Molecular and genetic aspects of obesity, vol 5. Baton Rouge, Louisiana State University Press, pp 219–232

    Google Scholar 

  • Kalra SP, Sahu A, Kalra PS (1993) Ageing of the neuropeptidergic signals in rats. J Reprod Fertil Suppl 46:11–19

    PubMed  CAS  Google Scholar 

  • Kalra SP, Sahu A, Kalra PS, Crowley WR (1990) Hypothalamic neuropeptide Y: a circuit in the regulation of gonadotropin secretion and feeding behavior. Ann N Y Acad Sci 611:273–283

    PubMed  CAS  Google Scholar 

  • Kalra SP, Xu B, Dube M, Kaibara A, Martin D, Moldawer LL (1996b) Ciliary neurotropic factor is a potent anorectic cytokine acting through hypothalamic neuropeptide Y. 26th Annual Society for Neuroscience. Washington DC, November 1996 (abstract p 1352)

    Google Scholar 

  • Kalra SP, Xu B, Dube MG, Moldawer LL, Martin D, Kalra PS (1998d) Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y. Neurosci Lett 240:45–49

    PubMed  CAS  Google Scholar 

  • King PJ, Williams G, Doods H, Widdowson PS (2000) Effect of a selective neuropeptide Y Y(2) receptor antagonist, BIIE0246 on neuropeptide Y release. Eur J Pharmacol 396: R1–R3

    PubMed  CAS  Google Scholar 

  • Kushi A, Sasai H, Koizumi H, Takeda N, Yokoyama M, Nakamura M (1998) Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proc Natl Acad Sci USA 95:15659–15664

    PubMed  CAS  Google Scholar 

  • Larhammar D, Wraith A, Berglund MM, Holmberg SK, Lundell I (2001) Origins of the many NPY-family receptors in mammals. Peptides 22:295–307

    PubMed  CAS  Google Scholar 

  • Leupen SM, Besecke LM, Levine JE (1997) Neuropeptide Y Y1-receptor stimulation is required for physiological amplification of preovulatory luteinizing hormone surges. Endocrinology 138:2735–2739

    PubMed  CAS  Google Scholar 

  • Lopez M, Seoane LM, Garcia Mdel C, Dieguez C, Senaris R (2002) Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus. Neuroendocrinology 75:34–44

    PubMed  CAS  Google Scholar 

  • Magni P (2003) Hormonal control of the neuropeptide y system. Curr Protein Pept Sci 4:45–57

    PubMed  CAS  Google Scholar 

  • Marin-Bivens CL, Kalra SP, Olster DH (1998) Intraventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female rats. Regul Pept 75/76:327–334

    Google Scholar 

  • Marsh DJ, Hollopeter G, Kafer KE, Palmiter RD (1998) Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nature Med 4:718–721

    PubMed  CAS  Google Scholar 

  • Naveilhan P, Hassani H, Canals JM, Ekstrand AJ, Larefalk A, Chhajlani V, Arenas E, Gedda K, Svensson L, Thoren P, Ernfors P (1999) Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nature Med 5:1188–1193.

    PubMed  CAS  Google Scholar 

  • Naveilhan P, Svensson L, Nystrom S, Ekstrand AJ, Ernfors P (2002) Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation. Peptides 23:1087–1091

    PubMed  CAS  Google Scholar 

  • Ovesjo ML, Gamstedt M, Collin M, Meister B (2001) GABAergic nature of hypothalamic leptin target neurones in the ventromedial arcuate nucleus. J Neuroendocrinol 13:505–516

    PubMed  CAS  Google Scholar 

  • Pedrazzini T, Seydoux J, Kunstner P, Aubert JF, Grouzmann E, Beermann F, Brunner HR (1998) Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nature Med 4:722–726

    PubMed  CAS  Google Scholar 

  • Poggioli R, Vergoni AV, Marrama D, Giuliani D, Bertolini A (1990) NPY-induced inhibition of male copulatory activity is a direct behavioural effect. Neuropeptides 16:169–172

    PubMed  CAS  Google Scholar 

  • Pralong FP, Gonzales C, Voirol MJ, Palmiter RD, Brunner HR, Gaillard RC, Seydoux J, Pedrazzini T (2002) The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions. FASEB J 16:712–714

    PubMed  CAS  Google Scholar 

  • Pronchuk N, Beck-Sickinger AG, Colmers WF (2002) Multiple NPY receptors Inhibit GABA(A) synaptic responses of rat medial parvocellular effector neurons in the hypothalamic paraventricular nucleus. Endocrinology 143:535–543

    PubMed  CAS  Google Scholar 

  • Pu S, Dhillon H, Moldawer LL, Kalra PS, Kalra SP (2000a) Neuropeptide Y counteracts the anorectic and weight reducing effects of ciliary neurotropic factor. J Neuroendocrinol 12:827–832

    PubMed  CAS  Google Scholar 

  • Pu S, Dube MG, Edwards TG, Kalra SP, Kalra PS (1999a) Disruption of neural signaling within the hypothalamic ventromedial nucleus upregulates galanin gene expression in association with hyperphagia: an in situ hybridization analysis. Brain Res Mol Brain Res 64:85–91

    PubMed  CAS  Google Scholar 

  • Pu S, Dube MG, Kalra PS, P. KS (2000b) Regulation of leptin secretion: Effects of aging on daily patterns of serum leptin and food consumption. Regul Pept 92:107–111

    PubMed  CAS  Google Scholar 

  • Pu S, Dube MG, Xu B, Kalra SP, Kalra PS (1998a) Induction of neuropeptide Y (NPY) gene expression in novel hypothalamic sites in association with transient hyperphagia and body weight gain. 80th Annual Meeting of the Endocrine Society. New Orleans, June 1998 (abstract p301)

    Google Scholar 

  • Pu S, Horvath TL, Diano S, Naftolin F, Kalra PS, Kalra SP (1997a) Evidence showing that beta-endorphin regulates cyclic guanosine 3’,5’-monophosphate (cGMP) efflux: anatomical and functional support for an interaction between opiates and nitric oxide. Endocrinology 138:1537–1543

    PubMed  CAS  Google Scholar 

  • Pu S, Jain MR, Horvath TL, Diano S, Kalra PS, Kalra SP (1999) Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology 140:933–940

    PubMed  CAS  Google Scholar 

  • Pu S, Jain MR, Horvath TL, Diano S, Kalra PS, Kalra SP (1999b) Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology 140:933–940

    PubMed  CAS  Google Scholar 

  • Pu S, Kalra PS, Kalra SP (1999c) Energy homeostasis and reproduction are regulated by different subpopulations of neuropeptide Y (NPY) neurons in the arcuate nucleus. 81st Annual Meeting of the Endocrine Society. San Diego, June 1999 (abstract p236)

    Google Scholar 

  • Pu S, Jain MR, Kalra PS, Kalra SP (1998b) Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroiddependent manner. Regul Pept 78:133–136

    PubMed  CAS  Google Scholar 

  • Pu S, Kalra PS, Kalra SP (1998c) Diurnal rhythm in cyclic GMP/nitric oxide efflux in the medial preoptic area of male rats. Brain Res 808:310–312

    PubMed  CAS  Google Scholar 

  • Pu S, Dube MG, Kalra, SP and Kalra PS (2003) Permanent interruption of information flow between hypothalamus and hindbrain produces obesity accompanied by a selective dark-phase hyperphagia and hyperinsulinemia. 33rd Annual Society for Neuroscience Meeting, New Orleans. November 2003 (abstract in press)

    Google Scholar 

  • Raposinho PD, White RB, Aubert ML (2003) The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. J Neuroendocrinol 15:173–181

    PubMed  CAS  Google Scholar 

  • Sahu A (2002) Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats. Brain Res 944:232–238

    PubMed  CAS  Google Scholar 

  • Sahu A, Crowley WR, Kalra PS, Kalra SP (1992a) A selective sexually dimorphic response in the median eminence neuropeptide Y. Brain Res 573:235–242

    PubMed  CAS  Google Scholar 

  • Sahu A, Crowley WR, Kalra SP (1990a) An opioid-neuropeptide-Y transmission line to luteinizing hormone (LH)-releasing hormone neurons: a role in the induction of LH surge. Endocrinology 126:876–883

    PubMed  CAS  Google Scholar 

  • Sahu A, Crowley WR, Kalra SP (1994a) Hypothalamic neuropeptide-Y gene expression increases before the onset of the ovarian steroid-induced luteinizing hormone surge. Endocrinology 134:1018–1022

    PubMed  CAS  Google Scholar 

  • Sahu A, Crowley WR, Kalra SP (1995) Evidence that hypothalamic neuropeptide Y gene expression increases before the onset of the preovulatory LH surge. J Neuroendocrinol 7:291–296

    PubMed  CAS  Google Scholar 

  • Sahu A, Crowley WR, Tatemoto K, Balasubramaniam A, Kalra SP (1987a) Effects of neuropeptide Y, NPY analog (norleucine4-NPY), galanin and neuropeptide K on LH release in ovariectomized (ovx) and ovx estrogen, progesterone-treated rats. Peptides 8:921–926

    PubMed  CAS  Google Scholar 

  • Sahu A, Dube MG, Kalra SP, Kalra PS (1988a) Bilateral neural transections at the level of mesencephalon increase food intake and reduce latency to onset of feeding in response to neuropeptide Y. Peptides 9:1269–1273

    PubMed  CAS  Google Scholar 

  • Sahu A, Jacobson W, Crowley WR, Kalra SP (1989) Dynamic changes in neuropeptide Y concentrations in the median eminence in neuropeptide Y concentrations in the median eminence in association with preovulatory luteinizing hormone (LH) release in the rat. J Neuroendo 1:83–87

    CAS  Google Scholar 

  • Sahu A, Kalra PS, Crowley WR, Kalra SP (1988b) Evidence that hypothalamic neuropeptide Y secretion decreases in aged male rats: implications for reproductive aging. Endocrinology 122:2199–2203

    PubMed  CAS  Google Scholar 

  • Sahu A, Kalra PS, Kalra SP (1988c) Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 9:83–86

    PubMed  CAS  Google Scholar 

  • Sahu A, Kalra SP (1998) Absence of increased neuropeptide Y neuronal activity before and during the luteinizing hormone (LH) surge may underlie the attenuated preovulatory LH surge in middle-aged rats. Endocrinology 139:696–702

    PubMed  CAS  Google Scholar 

  • Sahu A, Kalra SP, Crowley WR, Kalra PS (1988d) Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior. Brain Res 457:376–378

    PubMed  CAS  Google Scholar 

  • Sahu A, Kalra SP, Crowley WR, O’Donohue TL, Kalra PS (1987b) Neuropeptide Y levels in microdissected regions of the hypothalamus and in vitro release in response to KCl and prostaglandin E2: effects of castration. Endocrinology 120:1831–1836

    PubMed  CAS  Google Scholar 

  • Sahu A, Phelps CP, White JD, Crowley WR, Kalra SP, Kalra PS (1992b) Steroidal regulation of hypothalamic neuropeptide Y release and gene expression. Endocrinology 130:3331–3336

    PubMed  CAS  Google Scholar 

  • Sahu A, Sninsky CA, Kalra PS, Kalra SP (1990b) Neuropeptide-Y concentration in microdissected hypothalamic regions and in vitro release from the medial basal hypothalamus-preoptic area of streptozotocin-diabetic rats with and without insulin substitution therapy. Endocrinology 126:192–198

    PubMed  CAS  Google Scholar 

  • Sahu A, Sninsky CA, Kalra SP (1997) Evidence that hypothalamic neuropeptide Y gene expression and NPY levels in the paraventricular nucleus increase before the onset of hyperphagia in experimental diabetes. Brain Res 755:339–342

    PubMed  CAS  Google Scholar 

  • Sahu A, Sninsky CA, Phelps CP, Dube MG, Kalra PS, Kalra SP (1992c) Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats. Endocrinology 131:2979–2985

    PubMed  CAS  Google Scholar 

  • Sahu A, White JD, Kalra PS, Kalra SP (1992d) Hypothalamic neuropeptide Y gene expression in rats on scheduled feeding regimen. Brain Res Mol Brain Res 15:15–18

    PubMed  CAS  Google Scholar 

  • Sahu A, Xu B, Kalra SP (1994b) Role of galanin in stimulation of pituitary luteinizing hormone secretion as revealed by a specific receptor antagonist, galantide. Endocrinology 134:529–536

    PubMed  CAS  Google Scholar 

  • Sainsbury A, Schwarzer C, Couzens M, Fetissov S, Furtinger S, Jenkins A, Cox HM, Sperk G, Hokfelt T, Herzog H (2002a) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc Natl Acad Sci USA 99:8938–8943

    PubMed  CAS  Google Scholar 

  • Sainsbury A, Schwarzer C, Couzens M, Jenkins A, Oakes SR, Ormandy CJ, Herzog H (2002b) Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev 16:1077–1088

    PubMed  CAS  Google Scholar 

  • Sar M, Sahu A, Crowley WR, Kalra SP (1990) Localization of neuropeptide-Y immunoreactivity in estradiol-concentrating cells in the hypothalamus. Endocrinology 127:2752–2756

    PubMed  CAS  Google Scholar 

  • Silva AP, Cavadas C, Grouzmann E (2002) Neuropeptide Y and its receptors as potential therapeutic drug targets. Clin Chim Acta 326:3–25.

    PubMed  CAS  Google Scholar 

  • Smith MS (1993) Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat. Endocrinology 133:1258–1265

    PubMed  CAS  Google Scholar 

  • Smith MS, Grove KL (2002) Integration of the regulation of reproductive function and energy balance: lactation as a model. Front Neuroendocrinol 23:225–256

    PubMed  CAS  Google Scholar 

  • Toufexis DJ, Kyriazis D, Woodside B (2002) Chronic neuropeptide Y Y5 receptor stimulation suppresses reproduction in virgin female and lactating rats. J Neuroendocrinol 14:492–497

    PubMed  CAS  Google Scholar 

  • Tschop M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407:908–913

    PubMed  CAS  Google Scholar 

  • Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C (2001) Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 24:RC19–RC21

    PubMed  CAS  Google Scholar 

  • Turnbull AV, Ellershaw L, Masters DJ, Birtles S, Boyer S, Carroll D, Clarkson P, Loxham SJ, McAulay P, Teague JL, Foote KM, Pease JE, Block MH (2002) Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 51:2441–2449

    PubMed  CAS  Google Scholar 

  • Woller MJ, McDonald JK, Reboussin DM, Terasawa E (1992) Neuropeptide Y is a neuromodulator of pulsatile luteinizing hormone-releasing hormone release in the gonadectomized rhesus monkey. Endocrinology 130:2333–2342

    PubMed  CAS  Google Scholar 

  • Xu B, Kalra PS, Farmerie WG, Kalra SP (1999) Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: effects of food restriction. Endocrinology 140:2868–2875

    PubMed  CAS  Google Scholar 

  • Xu B, Kalra PS, Kalra SP (1996a) Food restriction upregulates hypothalamic NPY gene expression: loss of daily rhythmicity. 26th Annual Meeting of the Society for Neuroscience. Washington, DC, November 1996 (abstract p 1685)

    Google Scholar 

  • Xu B, Kalra PS, Moldawer LL, Kalra SP (1998) Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factor. Regul Pept 75/76:391–395

    Google Scholar 

  • Xu B, Pu S, Kalra PS, Hyde JF, Crowley WR, Kalra SP (1996b) An interactive physiological role of neuropeptide Y and galanin in pulsatile pituitary luteinizing hormone secretion. Endocrinology 137:5297–5302

    PubMed  CAS  Google Scholar 

  • Xu B, Sahu A, Crowley WR, Leranth C, Horvath T, Kalra SP (1993) Role of neuropeptide-Y in episodic luteinizing hormone release in ovariectomized rats: an excitatory component and opioid involvement. Endocrinology 133:747–754

    PubMed  CAS  Google Scholar 

  • Xu B, Sahu A, Kalra PS, Crowley WR, Kalra SP (1996c) Disinhibition from opioid influence augments hypothalamic neuropeptide Y (NPY) gene expression and pituitary luteinizing hormone release: effects of NPY messenger ribonucleic acid antisense oligodeoxynucleotides. Endocrinology 137:78–84

    PubMed  CAS  Google Scholar 

  • Xu M, Hill JW, Levine JE (2000a) Attenuation of luteinizing hormone surges in neuropeptide Y knockout mice. Neuroendocrinology 72:263–271

    PubMed  CAS  Google Scholar 

  • Xu M, Urban JH, Hill JW, Levine JE (2000b) Regulation of hypothalamic neuropeptide Y Y1 receptor gene expression during the estrous cycle: role of progesterone receptors. Endocrinology 141:3319–3327

    PubMed  CAS  Google Scholar 

  • Yokosuka M, Dube MG, Kalra PS, Kalra SP (2001) The mPVN mediates blockade of NPY-induced feeding by a Y5 receptor antagonist: a c-FOS analysis. Peptides 22:507–514

    PubMed  CAS  Google Scholar 

  • Yokosuka M, Kalra PS, Kalra SP (1999) Inhibition of neuropeptide Y (NPY)-induced feeding and c-Fos response in magnocellular paraventricular nucleus by a NPY receptor antagonist: a site of NPY action. Endocrinology 140:4494–4500

    PubMed  CAS  Google Scholar 

  • Yokosuka M, Xu B, Pu S, Kalra PS, Kalra SP (1998) Neural substrates for leptin and neuropeptide Y (NPY) interaction: hypothalamic sites associated with inhibition of NPY-induced food intake. Physiol Behav 64:331–338

    PubMed  CAS  Google Scholar 

  • Zammaretti F, Panzica G, Eva C (2001) Fasting, leptin treatment, and glucose administration differentially regulate Y(1) receptor gene expression in the hypothalamus of transgenic mice. Endocrinology 142:3774–3782

    PubMed  CAS  Google Scholar 

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  1. Departments of Neuroscience and Physiology and Functional Genomics, College of Medicine, University of Florida McKnight Brain Institute, 100 S. Newell Drive, Gainesville, FL, 32610-0244, USA

    S. P. Kalra & P. S. Kalra

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  1. Afd. Farmacologie & Farmacotherapie, Academisch Medisch Centrum, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    Martin C. Michel

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Kalra, S.P., Kalra, P.S. (2004). NPY: A Novel On/Off Switch for Control of Appetite and Reproduction. In: Michel, M.C. (eds) Neuropeptide Y and Related Peptides. Handbook of Experimental Pharmacology, vol 162. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18764-3_8

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