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Induction Chemotherapy pp 59–69Cite as

The Role of Hypoxia and Hyperthermia in Chemotherapy

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Abstract

Tumor hypoxia is the condition where cancer cells have been deprived of oxygen. As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. Hypoxic tumor cells are usually resistant to chemotherapy and radiotherapy, but they can be made more susceptible to treatment by increasing the amount of oxygen in them. Cancer physiology can be a new significant target for therapy.

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Author information

Authors and Affiliations

  1. Department of Oncology, “San Giuseppe” General City Hospital, Empoli (FI), Italy

    Giammaria Fiorentini, Francesco Montagnani & Michelina D’Alessandro

  2. Department of Oncology, Carrara City Hospital, Massa-Carrara, Italy

    Maurizio Cantore & Andrea Mambrini

  3. Department of Surgical Sciences, University of L’Aquila, L’Aquila, Italy

    Stefano Guadagni

Authors
  1. Giammaria Fiorentini
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  2. Maurizio Cantore
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  3. Francesco Montagnani
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  4. Andrea Mambrini
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  5. Michelina D’Alessandro
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  6. Stefano Guadagni
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Corresponding author

Correspondence to Giammaria Fiorentini .

Editor information

Editors and Affiliations

  1. Abt. Onkologische Chirurgie, Medias Klinikum GmbH & Co. KG, Krankenhausstr. 1, Burghausen, 84489, Germany

    Karl Reinhard Aigner

  2. Inkerman Street 16, Mosman, 2088, New South Wales, Australia

    Frederick O. Stephens

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© 2011 Springer-Verlag Berlin Heidelberg

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Fiorentini, G., Cantore, M., Montagnani, F., Mambrini, A., D’Alessandro, M., Guadagni, S. (2011). The Role of Hypoxia and Hyperthermia in Chemotherapy. In: Aigner, K., Stephens, F. (eds) Induction Chemotherapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18173-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-18173-3_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-18172-6

  • Online ISBN: 978-3-642-18173-3

  • eBook Packages: MedicineMedicine (R0)

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