Abstract
Hyperthermia is a rise in core body temperature above the physiological norm. Used for centuries as a remedy for a range of afflictions, heat therapy is now recognised as an effective adjunct in the treatment of many cancers. Hyperthermia maybe induced locally in tissues to target a specific disease focus, or regionally in an extremity or body cavity. Its usefulness stems from its ability to damage malignant cells whilst relatively sparing normal tissues, and from its synergism with chemotherapy and radiotherapy. This chapter describes the rationale and uses for local and regional hyperthermia in the treatment of malignant disease.
Keywords
- Isolate Limb Perfusion
- Pseudomyxoma Peritonei
- Isolate Limb Infusion
- Local Hyperthermia
- Regional Hyperthermia
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Aphorisms by Hippocrates. Translated by Francis Adams. Available at http://classics.mit.edu/Hippocrates/aphorisms.html. accessed 8 February 2010.
Coley WB. The treatment of malignant tumours by repeated inoculations of erysipelas with a report of ten original cases. Am J Med Sci. 1893;104:487–511.
Byrne J. A digest of 20 years’ experience in the treatment of cancer of the uterus by galvanocautery. Am J Obstet Gynecol. 1899;22:1052.
Percy JF. Heat the most practical and promising treatment in uterine carcinoma. Calif State J Med. 1921;19:78–81.
Cavaliere R, Ciocatto EC, Giovanella BP, Heidelberger C, Johnson RO, Margottini M, et al. Selective heat sensitivity of cancer cells – biochemical and clinical studies. Cancer. 1967;20:1351–81.
Overgaard J. Effect of hyperthermia on malignant cells in vivo: a review and a hypothesis. Cancer. 1977;39:2637–46.
Dudar TE, Jain RK. Differential response of normal and tumour microcirculation to hyperthermia. Cancer Res. 1984;44:605–12.
Dickson JA, Calderwood SK. Temperature range and selective sensitivity of tumours to hyperthermia: a critical review. Ann NY Acad Sci. 1980;335:180–205.
Urano M. Kinetics of thermotolerance in normal and tumour tissue: a review. Cancer Res. 1986;46:474–82.
Song CW, Park HJ, Lee CK, Griffin R. Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment. Int J Hyperthermia. 2005;21:761–7.
Vernon CC, Hand JW, Field SB, Machin D, Whaley JB, van der Zee J, et al. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials – International Collaborative Hyperthermia Group. Int J Radiat Oncol Biol Phys. 1996;35:731–44.
Sneed PK, Stauffer PR, McDermott MW, Diederich CJ, Lamborn KR, Prados MD, et al. Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/− hyperthermia for glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 1998;40:287–95.
De Haas-Kock DFM, Buijsen J, Pijls-Johannesma M, Lutgens L, Lammering G, Mastrigt GAPGV, De Ruysscher DKM, Lambin P, van der Zee J. Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer. Cochrane Database Syst Rev. 2009, 3.
Hahn GM, Strande DP. Cytotoxic effects of hyperthermia and adriamycin on Chinese hamster cell. J Natl Cancer Inst. 1976;37:1063–7.
Hahn GM. Potential for therapy of drugs and hyperthermia. Cancer Res. 1979;39:2264–8.
Goldfeder A, Newport S. Thermally-enhanced tumour regression in mice treated with melphalan. Anticancer Res. 1984;4:17–22.
Barlogie B, Corry PM, Drewinko B. In vitro thermochemotherapy of human colon cancer cells with cis-dichlordiammineplatinum(II) and mitomycin C. Cancer Res. 1980;40:1165–8.
Zwischenberger JB, Vertrees RA, Bedell EA, McQuitty CK, Chernin JM, Woodson LC. Percutaneous venovenous perfusion-induced systemic hyperthermia for lung cancer: a phase I safety study. Ann Thorac Surg. 2004;77:1916–25.
Larkin JM, Edwards WS, Smith DE, Clark PJ. Systemic thermotherapy: description of a method and physiological tolerance in clinical subjects. Cancer. 1977;40:3155–9.
Pettigrew RT, Galt JM, Ludgate CM, Smith AN. Clinical effects of whole body hyperthermia in advanced malignancy. Br Med J. 1974;4:679–82.
Creech O, Krementz ET, Ryan RF, Winblad JN. Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg. 1958;148:616–32.
Urano M, Ling CC. Thermal enhancement of melphalan and oxaliplatin cytotoxicity in vitro. Int J Hyperthermia. 2002;18:307–15.
Minor DR, Allen RE, Alberts D, Peng YM, Tardelli G, Hutchinson J. A clinical and pharmacokinetic study of isolated limb perfusion with heat and melphalan for melanoma. Cancer. 1985;55:2638–44.
Thompson JF, Kam PC, Waugh RC, Harman CR. Isolated limb infusion with cytotoxic agents: a simple alternative to isolated limb perfusion. Semin Surg Oncol. 1998;14:238–47.
Grünhagen DJ, de Wilt JHW, van Geel AN, Eggermont AMM. Isolated limb perfusion for melanoma patients – a review of its indications and the role of tumour necrosis factor-α. Eur J Surg Oncol. 2006;32:371–80.
de Wilt JH, Manusama ER, van Tiel ST, van Ijken MG, ten Hagen TL, Eggermont AM. Prerequisites for effective isolated limb perfusion using tumour necrosis factor alpha and melphalan in rats. Br J Cancer. 1999;80:161–6.
Esquivel J, Sticca R, Sugarbaker P, Levine E, Yan TD, Alexander R, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Ann Surg Oncol. 2007;14:128–33.
Yan TD, Black D, Savady R, Sugarbaker PH. A systematic review on the efficacy of cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei. Ann Surg Oncol. 2007;14:484–92.
Yano H, Moran BJ, Cecil TD, Murphy EM. Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal mesothelioma. Eur J Surg Oncol. 2009;35:980–5.
Yan TD, Deraco M, Baratti D, Kusamura S, Elias D, Glehen O, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience. J Clin Oncol. 2009;27:6237–42.
Spratt JS, Adcock RA, Muscovin M, Sherril W, McKeown J. Clinical delivery system for intraperitoneal hyperthermic chemotherapy. Cancer Res. 1980;40:256–60.
Los G, Mutsaers PH, van der Vijgh WJ, Baldew GS, de Graaf PW, McVie JG. Direct diffusion of cis-diamminedichloroplatinum(II) in intraperitoneal rat tumours after intraperitoneal chemotherapy: a comparison with systemic chemotherapy. Cancer Res. 1989;49:3380–4.
Van de Vaart PJ, van der Vange N, Zoetmulder FA, van Goethem AR, van Tellingen O, ten Bokkel Huinink WW, et al. Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines. Eur J Cancer. 1998;34:148–54.
Witkamp AJ, de Bree E, Kaag MM, van Slooten GW, van Coevorden F, Zoetmulder FAN. Extensive surgical cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in patients with pseudomyxoma pertonei. Br J Surg. 2001;88:458–63.
Jaquet P, Averbach A, Stuart OA, Chang D, Sugarbaker PH. Hyperthermic intraperitoneal doxorubicin: pharmacokinetics, metabolism and tissue distribution in a art model. Cancer Chemother Pharmacol. 1998;41:147–54.
Izzo F. New approaches to hepatic malignancies: other thermal ablation techniques: microwave and interstitial laser ablation of liver tumors. Ann Surg Oncol. 2002;10:491–7.
Walther W, Stein U. Heat-responsive gene expression for gene therapy. Adv Drug Deliv Rev. 2009;61:641–9.
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Habib, M.R., Morris, D.L. (2011). Local and Regional Hyperthermia. In: Aigner, K., Stephens, F. (eds) Induction Chemotherapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18173-3_5
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