Abstract
Mosquito-borne diseases are the number-one killers of humans worldwide. A major obstacle in controlling these diseases is that mosquitoes have developed resistance to insecticides, including pyrethroids, which are currently the most widely used insecticides for the indoor control of mosquitoes and are the only chemicals recommended for the treatment of mosquito nets, the main tool for preventing malaria in Africa. A large number of studies have shown that multiple, complex resistance mechanisms or genes are likely to be responsible for insecticide resistance and gene overexpression, amplification, and structural mutations have frequently been linked to insecticide resistance in mosquitoes. Among them, the two major mechanisms involved in the development of insecticide resistance are: (1) increased metabolic detoxification of the insecticides and (2) decreased sensitivity of the target sites to the insecticides (i.e., target site insensitivity). In this chapter, we will summarize our current research and knowledge on the molecular mechanisms governing insecticide resistance development in mosquitoes.
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© 2011 Higher Education Press, Beijing and Springer-Verlag Berlin Heidelberg
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Xu, Q., Liu, N. (2011). The Development of Pyrethroid Resistance in the Mosquito Culex quinquefasciatus . In: Liu, T., Kang, L. (eds) Recent Advances in Entomological Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17815-3_17
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DOI: https://doi.org/10.1007/978-3-642-17815-3_17
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