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Lymphotoxin/Tumour Necrosis Factor Family Members as Morphogenic Factors

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Book cover Developmental Biology of Peripheral Lymphoid Organs
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Abstract

Initially described as potent soluble mediators involved in inflammation, Tumour Necrosis Factor (TNF) and lymphotoxin alpha and beta (LTα/β) are now also appreciated as cardinal morphogenic regulators in secondary lymphoid organ formation, in addition to related activities of other members of the same TNF/LT family. Their developmental effects simultaneously show both substantial overlaps and remarkable tissue-specific differences. This part details the receptor–ligand relationship and developmental roles of those members of this large group of soluble or membrane-bound cytokines that have been associated with secondary lymphoid organ formation.

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Balogh, P. (2011). Lymphotoxin/Tumour Necrosis Factor Family Members as Morphogenic Factors. In: Balogh, P. (eds) Developmental Biology of Peripheral Lymphoid Organs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14429-5_3

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