Chapter

Structures and Organelles in Pathogenic Protists

Volume 17 of the series Microbiology Monographs pp 299-318

Date:

Calcium Homeostasis and Acidocalcisomes in Trypanosoma cruzi

  • Paul UlrichAffiliated withCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia
  • , Roxana CintrónAffiliated withCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia
  • , Roberto DocampoAffiliated withCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia Email author 

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Calcium ion (Ca2+) is an important second messenger in Trypanosoma cruzi and is essential for invasion of host cells by this parasite. A number of transporters and channels in the plasma membrane, endoplasmic reticulum, and mitochondria regulate cytosolic calcium concentration. Additionally, the T. cruzi genome contains a wide variety of signaling and regulatory proteins that bind calcium as well as many putative calcium-binding proteins that await further characterization. In T. cruzi, acidic organelles known as acidocalcisomes are the primary reservoir of intracellular calcium and mediate polyphosphate metabolism, osmoregulation, and calcium and pH homeostasis.