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The Remarkable Mitochondrion of Trypanosomes and Related Flagellates

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Structures and Organelles in Pathogenic Protists

Part of the book series: Microbiology Monographs ((MICROMONO,volume 17))

Abstract

While the single mitochondrion of trypanosomatid flagellates contains many of the hallmarks that are known from mitochondria in other conventional model organisms, it also possesses several unique features, making it a subject of intense research. Here, we summarize current knowledge of the (1) structure, maintenance and replication of the extensive kinetoplastid DNA network, (2) byzantine organellar RNA metabolism, including insertion/deletion RNA editing, (3) translation of mitochondrial-encoded proteins, and, finally, (4) distinctive aspects of energy metabolism of the organelle. While we focus on the mitochondrion of Trypanosoma brucei, particularly in the context of its radical physiological and biochemical changes during the life cycle of the parasite, in order to get a more complete picture of the workings of this fascinating organelle, we also discuss significant findings obtained from other trypanosomatids.

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Authors and Affiliations

  1. Biology Centre, Institute of Parasitology, Czech Academy of Science and Faculty of Science, University of South Bohemia, České Budějovice (Budweis), Czech Republic

    Julius Lukeš, Hassan Hashimi, Zdeněk Verner & Zdeňka Čičová

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  1. Julius Lukeš
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  2. Hassan Hashimi
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  3. Zdeněk Verner
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  4. Zdeňka Čičová
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Correspondence to Julius Lukeš .

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  1. Inst. Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, 21949-900, Rio de Janeiro, Brazil

    W. de Souza

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Lukeš, J., Hashimi, H., Verner, Z., Čičová, Z. (2010). The Remarkable Mitochondrion of Trypanosomes and Related Flagellates. In: de Souza, W. (eds) Structures and Organelles in Pathogenic Protists. Microbiology Monographs, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12863-9_10

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