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Innate Immunity in Pathogenesis and Treatment of Dermatomycosis

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Combating Fungal Infections

Abstract

Innate and cell-mediated immunity are considered as the principal defense lines against fungal infections in humans. Most opportunistic mycoses occur in individuals with defective innate and/or adaptive cellular immunity. Skin and nail infections caused by dermatophyte fungi have become more common in recent years. The capacity of the skin (mainly stratum corneum) to resist infection depends on the innate, cutaneous production of molecules known as antimicrobial peptides (AMPs), and expression of some AMPs further increases in response to microbial invasion. Emerging evidence suggests that some of these peptides are important to immune defense by acting not only as natural antibiotics but also as cell-signaling molecules. Cathelicidins are unique AMPs that protect the skin. Therapies targeting control of cathelicidin and other AMPs might provide new approaches in the management of infectious skin diseases. A better understanding of reciprocal regulation between innate, humoral, and adaptive immune responses in the development of an optimal antifungal immunity may lead to a clarification of the mechanisms involved in host immunity to fungal infections. In this chapter, we review some of the dermatomycosis diseases, their casual agents, the role of innate immunity in pathogenesis, and treatment.

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Authors and Affiliations

  1. Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202002, UP, India

    Mohammad Owais, Mairaj Ahmed Ansari, Qamar Zia & Arun Chauhan

  2. Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh, 202002, India

    Iqbal Ahmad

  3. Dermatopathology Department, University Hospital of Liège, Liège, Belgium

    Gerald Pierard

Authors
  1. Mohammad Owais
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  2. Mairaj Ahmed Ansari
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  3. Iqbal Ahmad
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  4. Qamar Zia
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  5. Gerald Pierard
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  6. Arun Chauhan
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Corresponding author

Correspondence to Mohammad Owais .

Editor information

Editors and Affiliations

  1. Fac. Agricultural Sciences, Dept. Agricultural Microbiology, Aligarh Muslim University, Aligarh, 202002, India

    Iqbal Ahmad

  2. Dept. Biochemistry, Interdiciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202 002, India

    Mohammad Owais

  3. J. N. Medical College, Dept. Microbiology, Aligarh Muslim University, Aligarh, 202002, India

    Mohammed Shahid

  4. James Graham Brown Cancer Center, S. Preston Street 580, Louisville, 40202, USA

    Farrukh Aqil

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Owais, M., Ansari, M.A., Ahmad, I., Zia, Q., Pierard, G., Chauhan, A. (2010). Innate Immunity in Pathogenesis and Treatment of Dermatomycosis. In: Ahmad, I., Owais, M., Shahid, M., Aqil, F. (eds) Combating Fungal Infections. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12173-9_15

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