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Combating Fungal Infections pp 327–346Cite as

Metabolic Pathways as Drug Targets: Targeting the Sulphur Assimilatory Pathways of Yeast and Fungi for Novel Drug Discovery

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Abstract

The incidence of fungal infections is increasing worldwide, and the management and treatment of fungal infections has become increasingly important. The antifungals which are currently available target only a few pathways, and their persistent use has resulted not only in increased drug resistance but also in the emergence of newer fungal pathogens with intrinsic resistance. There is thus an urgent need for novel antifungals. Among the metabolic pathways, the sulphur assimilatory pathways of the pathogenic yeasts and fungi appear to be suitable for antifungal development, due to the essential requirement of sulphur to the organism and the significant differences from the corresponding pathways in humans. In this chapter, we present the current understanding of the sulphur assimilatory pathways in different pathogenic yeast and fungi, and discuss several targets that are currently being investigated or have the potential for antifungal development.

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  1. Institute of Microbial Technology, Sector 39 A, Chandigarh, 160036, India

    Anand Kumar Bachhawat & Amit Kumar Yadav

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  1. Anand Kumar Bachhawat
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  2. Amit Kumar Yadav
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Correspondence to Anand Kumar Bachhawat .

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Editors and Affiliations

  1. Fac. Agricultural Sciences, Dept. Agricultural Microbiology, Aligarh Muslim University, Aligarh, 202002, India

    Iqbal Ahmad

  2. Dept. Biochemistry, Interdiciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202 002, India

    Mohammad Owais

  3. J. N. Medical College, Dept. Microbiology, Aligarh Muslim University, Aligarh, 202002, India

    Mohammed Shahid

  4. James Graham Brown Cancer Center, S. Preston Street 580, Louisville, 40202, USA

    Farrukh Aqil

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Bachhawat, A.K., Yadav, A.K. (2010). Metabolic Pathways as Drug Targets: Targeting the Sulphur Assimilatory Pathways of Yeast and Fungi for Novel Drug Discovery. In: Ahmad, I., Owais, M., Shahid, M., Aqil, F. (eds) Combating Fungal Infections. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12173-9_14

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