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Ischemic Optic Neuropathies pp 265–316Cite as

Pathogenesis of Classical Non-arteritic Anterior Ischemic Optic Neuropathy

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Abstract

Non-arteritic anterior ischemic optic neuropathy (NA-AION) is the most common type of ischemic optic neuropathy. Although findings of sudden onset of segmental visual field defect, initially with optic disc edema with a few peripapillary hemorrhages and later on optic atrophy were reported in the very early literature, the pathogenesis and management of NA-AION had been the focus of continuing controversy. To explain its pathogenesis, multiple theories have been postulated, varying from some degree of logic to some quite preposterous. NA-AION was referred to in the past as the “arteriosclerotic” variety, to distinguish it from arteritic AION associated with giant cell arteritis (GCA). It seems Uhthoff in 1924 first described three cases of the arteriosclerotic type [1]. The next major description seems to be by Francois et al. in 1956 [2]; they described this clinical entity under the title of “vascular pseudopapilitis”, and stressed the etiological importance of arteriosclerotic small vessel disease.

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  1. Department of Ophthalmology and Visual Science, University of Iowa Hospital and Clinics College of Medicine, Hawkins Dr. 200, Iowa City, IA, 52242–1091, USA

    Dr. Sohan Singh Hayreh

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Hayreh, S.S. (2011). Pathogenesis of Classical Non-arteritic Anterior Ischemic Optic Neuropathy. In: Ischemic Optic Neuropathies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11852-4_14

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