Wrapper Drugs for Personalized Medicine

Abstract

Personalized molecular therapy (“the right drug for the right person”) is regarded as a major imperative of post-genomic medicine. This perception is reinforced almost daily as promising therapeutic agents are recalled because of idiosyncratic side effects detected in small subpopulations of patients. However pressing the need, rational approaches to personalized drug therapy will ultimately and pivotally depend on our ability to translate genomic individualities and variations into molecular biomarkers that can guide a patient-tailored design. This chapter addresses this issue and describes how the wrapping design concept can be brought to fruition in this area. The chapter introduces plausible scenarios in which genomic idiosyncrasies and oncogenic variations may promote targetable differences in the wrapping patterns of the gene products.