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Optimization and Numerical Modeling in Irreversible Electroporation Treatment Planning

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Book cover Irreversible Electroporation

Part of the book series: Series in Biomedical Engineering ((BIOMENG))

Abstract

When you overhear someone mention treatment planning, you can bet the conversation is about one of the forms of radiation therapy (RT). In the 1960s, when high powered x-ray delivery systems were readily available to radiation oncologists, the biggest challenge remained to improve the accuracy in locating the tumor and in directing the beams of charged particles. This changed when the first computed tomography (CT) scanners were invented (Lampert et al, 1974). Availability of 3D anatomical data and ever increasing computer processing power gave rise to numerical treatment planning. Together with improved beam generation and delivery technology, treatment planning has enabled RT to better target the tumor and to reduce adverse effects on vital organs (Jaffray et al, 2007). This is exactly what researchers would also like to achieve with irreversible electroporation (IRE): ablate the target tissue and spare as much healthy tissue as possible. Just as treatment planning in RT provides radiation oncologist with the radiation beam intensities and directions that cover the tumor without causing extensive damage to healthy tissue, so can treatment planning in IRE provide physicians with electrode configurations and amplitudes of electric pulses that result in adequate electric field distribution in and around the target tissue.

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  1. Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, SI-1000, Slovenia

    Anže Županič & Damijan Miklavčič

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  1. Anže Županič
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  1. University of California at Berkeley, Berkeley, CA, USA

    Boris Rubinsky

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Županič, A., Miklavčič, D. (2010). Optimization and Numerical Modeling in Irreversible Electroporation Treatment Planning. In: Rubinsky, B. (eds) Irreversible Electroporation. Series in Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05420-4_8

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