Skip to main content

Evidence-Based Decisions in Human Immunodeficiency Virus Infection and Cardiac Disease

  • Chapter
  • First Online:
Book cover Evidence-Based Practice: Toward Optimizing Clinical Outcomes
  • 2365 Accesses

Abstract

This chapter is devoted to the spectrum of cardiac diseases seen in HIV-infected patients. The purpose of this chapter is to review the cardiovascular diseases associated with HIV infections and provide guidelines for the prevention and treatment of cardiac disease in HIV patients. Clinicians should be aware of the various cardiovascular manifestations of HIV infection, especially coronary artery disease, and should aggressively treat all risk factors in their patients with HIV infection. Patients with advanced HIV infection can have a variety of cardiovascular manifestations. The most common are: Pericarditis Coronary artery disease Myocardial disease: left ventricular dysfunction, myocarditis, cardiomyopathy Pulmonary hypertension Valvular disease AIDS-related malignancy Metabolic abnormalities associated with antiretroviral therapy Long QT syndrome Autonomic dysfunction Peripheral arterial disease

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Alonso-Villaverde C, Coll B, Parra S, Montero M, Calvo N, Tous N, Joven J, Masana L (2004) Atherosclerosis in patients infected with HIV is influenced by a mutant monocyte chemoattractant protein-1 allele. Circulation 110:2204–2209

    PubMed  CAS  Google Scholar 

  2. Anderson DW, Virmani R, Reilly JM et al (1988) Prevalent myocarditis at necropsy in the acquired immunodeficiency syndrome. J Am Coll Cardiol 11:792

    PubMed  CAS  Google Scholar 

  3. Anderson DW et al (1988) Prevalent myocarditis at necropsy in the acquired immunodeficiency syndrome. J Am Coll Cardiol 11:792–799

    PubMed  CAS  Google Scholar 

  4. Anson BD, Weaver JG, Ackerman MJ et al (2005) Blockade of HERG channels by HIV protease inhibitors. Lancet 365:682

    PubMed  CAS  Google Scholar 

  5. Aukrust P, Bjornsen S, Lunden B, Otterdal K, Ng EC, Ameln W, Ueland T, Muller F, Solum NO, Brosstad F, Froland SS (2000) Persistently elevated levels of von Willebrand factor antigen in HIV infection: downregulation during highly active antiretroviral therapy. Thromb Haemost 84:183–187

    PubMed  CAS  Google Scholar 

  6. Aupeix K et al (1997) The significance of shed membrane particles during programmed cell death in vitro, in HIV-1 infection. L Clin Invest 99:1546–1554

    CAS  Google Scholar 

  7. Badiou S, Merle De Boever C, Dupuy AM, Baillat V, Cristol JP, Reynes J (2004) Fenofibrate improves the atherogenic lipid profile and enhances LDL resistance to oxidation in HIV-positive adults. Atherosclerosis 172:273–279

    PubMed  CAS  Google Scholar 

  8. Bernal E, Masia M, Padilla S et al (2008) Low prevalence of peripheral arterial disease in HIV-infected patients with multiple cardiovascular risk factors. J Acquir Immune Defic Syndr 47:126

    PubMed  Google Scholar 

  9. Cammarosano C et al (1985) Cardiac lesion in acquired immune deficiency syndrome (AIDS). J Am Coll Cardiol 5:703–706

    PubMed  CAS  Google Scholar 

  10. Cardoso JS, Moura B, Martins L, Mota-Miranda A, Rocha Goncalves F, Lecour H (1998) Left ventricular dysfunction in human immunodeficiency virus (HIV)-infected patients. Int J Cardiol 63:37–45

    PubMed  CAS  Google Scholar 

  11. Cardoso JS, Moura B, Mota-Miranda A, Goncalves FR, Lecour H (1997) Zidovudine therapy and left ventricular function and mass in human immunodeficiency virus-infected patients. Cardiology 88:26–28

    PubMed  CAS  Google Scholar 

  12. Carr A et al (1999) Diagnosis, prediction and natural course of HIV-1 protease-inhibitor-associated lipodysthrophy, hyperlipidaemia, and diabetes mellitus: a cohort study. Lancet 353:2093–2099

    PubMed  CAS  Google Scholar 

  13. Cattelan AM, Trevenzoli M, Sasset L, Rinaldi L, Balasso V, Cadrobbi P (2001) Indinavir and systemic hypertension. AIDS 15:805–807

    PubMed  CAS  Google Scholar 

  14. Cegielski JP, Lwakatare J, Dukes CS et al (1994) Tuberculous pericarditis in Tanzanian patients with and without HIV infection. Tuber Lung Dis 75:429

    PubMed  CAS  Google Scholar 

  15. Centers for Disease Control (2005) Basic statistics from the Divisions of HIV/AIDS Prevention. Available at: http://www.cdc.gov/hiv/stats/htm

  16. Chen Y et al (1999) Human immunodeficiency virus-associated pericardial effusion: report of 40 cases and review of the literature. Am Heart J 137: 516–521

    PubMed  CAS  Google Scholar 

  17. Chow DC, Souza SA, Chen R, Richmond-Crum SM, Grandinetti A, Shikuma C (2003) Elevated blood pressure in HIV-infected individuals receiving highly active antiretroviral therapy. HIV Clin Trials 4:411–416

    PubMed  Google Scholar 

  18. Chyu KY, Birnbaum Y, Naqvi T et al (1998) Echocardiographic detection of Kaposi’s sarcoma causing cardiac tamponade in a patient with acquired immunodeficiency syndrome. Clin Cardiol 21:131

    PubMed  CAS  Google Scholar 

  19. Cicalini S, Forcina G, De Rosa FG (2001) Infective endocarditis in patients with human immunodeficiency virus infection. J Infect 42:267

    PubMed  CAS  Google Scholar 

  20. Cohen JA, Laudenslager M (1989) Autonomic nervous system involvement in patients with human immunodeficiency virus infection. Neurology 39:1111

    PubMed  CAS  Google Scholar 

  21. Constantino A, West TE, Gupta M, Loghmanee F (1987) Primary cardiac lymphoma in a patient with acquired immune deficiency syndrome. Cancer 60:2801

    PubMed  CAS  Google Scholar 

  22. Cool CD et al (2003) Expression of human herpesvirus 8 in primary pulmonary hypertension. N Engl J Med 349:1113–1122

    PubMed  CAS  Google Scholar 

  23. Currie PF, Sutherland GR, Jacob AJ et al (1995) A review of endocarditis in acquired immunodeficiency syndrome and human immunodeficiency virus infection. Eur Heart J 16 Suppl B:15

    PubMed  CAS  Google Scholar 

  24. D’Amati G et al (2001) Pathological findings of HIV-associated cardiovascular disease. Ann N Y Acad Sci 946:23–45

    PubMed  Google Scholar 

  25. Dalakas MC, Illa I, Pezeshkpour GH, Laukaitis JP, Cohen B, Griffin JL (1990) Mitochondrial myopathy caused by long-term zidovudine therapy. N Engl J Med 322:1098–1105

    PubMed  CAS  Google Scholar 

  26. Dube MP, Stein JH, Aberg JA, Fichtenbaum CJ, Gerber JG, Tashima KT, Henry WK, Currier JS, Sprecher D, Glesby MJ (2003) Guidelines for the evaluation and management of dyslipidemia in human immunodeficiency virus (HIV)-infected adults receiving antiretroviral therapy: recommendations of the HIV Medical Association of the Infectious Disease Society of America and the Adult AIDS Clinical Trials Group. Clin Infect Dis 37:613–627

    PubMed  Google Scholar 

  27. Dube MP et al (2003) For the Adult AIDS Clinical Trials Group Cardiovascular Subcommittee. Guidelines for the evaluation and management of dyslipidimia in human immunodeficiency virus (HIV)-infected adults receiving antiretroviral therapy: recommendations of the HIV Medical Association of the Infectious Disease Society of America and the Adult AIDS Clinical Trials Group. Clin Infect Dis 37: 613–627

    PubMed  Google Scholar 

  28. Eisenhauer MD, Eliasson AH, Taylor AJ et al (1994) Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients. Chest 105:389

    PubMed  CAS  Google Scholar 

  29. Fichtenbaum CJ, Gerber JG, Rosenkranz SL, Segal Y, Aberg JA, Blaschke T, Alston B, Fang F, Kosel B, Aweeka F (2002) Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG Study A5047. AIDS 16:569–577

    PubMed  CAS  Google Scholar 

  30. Fisher SD, Lipshultz SE (2001) Epidemiology of cardiovascular involvement in HIV disease and AIDS. Ann N Y Acad Sci 946:13–22

    PubMed  CAS  Google Scholar 

  31. Fisher SD, Lipshutz SE (2001) Epidemiology of cardiovascular involvement in HIV disease and AIDS. Ann N Y Acad Sci 946:13

    PubMed  CAS  Google Scholar 

  32. Flum DR, McGinn JT, Tyras DH (1995) The role of the ‘pericardial window’ in AIDS. Chest 107:1522–1525

    PubMed  CAS  Google Scholar 

  33. Freedberg RS, Gindea AJ, Dieterich DT, Greene JB (1987) Herpes simplex pericarditis in AIDS. N Y State J Med; 87:304–306

    PubMed  CAS  Google Scholar 

  34. Freeman R, Roberts MS, Friedman LS et al (1990) Autonomic function and human immunodeficiency virus infection. Neurology 40:575

    PubMed  CAS  Google Scholar 

  35. Friis-Moller N, Reiss P, Sabin CA, Weber R et al (2007) Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 356(17):1723–1735

    PubMed  Google Scholar 

  36. Frostegard J et al (1999) Cytokine expression in advances human atherosclerotic plaque: dominance of proinflammatory (TH1) and macrophage-stimulating cytokines. Atherosclerosis 145:33–43

    PubMed  CAS  Google Scholar 

  37. Gazzaruso C, Bruno R, Garzaniti A, Giordanetti S, Fratino P, Sacchi P, Filice G (2003) Hypertension among HIV patients: prevalence and relationships to insulin resistance and metabolic syndrome. J Hypertens 21:1377–1382

    PubMed  CAS  Google Scholar 

  38. Gebo KA, Burkey MD, Lucas GM et al (2006) Incidence of, risk factors for, clinical presentation, and 1-Year outcomes of infective endocarditis in an urban HIV cohort. J Acquir Immune Defic Syndr 43:426

    PubMed  Google Scholar 

  39. Goldfarb A, King CL, Rosenzweig BP et al (1989) Cardiac lymphoma in the acquired immunodeficiency syndrome. Am Heart J 118:1340

    PubMed  CAS  Google Scholar 

  40. Grinspoon S, Carr A (2005) Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med 352:48–62

    PubMed  CAS  Google Scholar 

  41. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C (2004) Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109:433–438

    PubMed  Google Scholar 

  42. Grundy SM, Hansen B, Smith SC Jr, Cleeman JI, Kahn RA (2004) Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation 109:551–556

    PubMed  Google Scholar 

  43. Grunfeld C et al (1992) Lipids, lipoproteins, triglycerides clearance, and cytokines in HIV infection and the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 74:1045–1052

    PubMed  CAS  Google Scholar 

  44. Hansson GK, Jonasson L, Lojsthed B, Stemme S, Kocher O, Gabbiani G (1988) Localization of T lymphocytes and macrophages in fibrous and complicated human atherosclerotic plaques. Atherosclerosis 72:135–141

    PubMed  CAS  Google Scholar 

  45. Hazenberg MD et al (2000) T-cell division in human immunodeficiency virus HIV-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 95:249–255

    PubMed  CAS  Google Scholar 

  46. Heidenreich PA, Eisenberg MJ, Kee LL et al (1995) Pericardial effusion in AIDS. Incidence and survival. Circulation 92:3229

    PubMed  CAS  Google Scholar 

  47. Heidenreich PA et al (1995) Pericardial effusion in AIDS. Circulation 92:3229–3234

    PubMed  CAS  Google Scholar 

  48. Hellerstein M et al (1999) Directly measures kinetics of circulating T lymphocytes in normal and HIV -1-infected humans. Nat Med 5:83–89

    PubMed  CAS  Google Scholar 

  49. Herskowitz A, Willoughby SB, Baughman KL, Schulman SP, Bartlett JD (1992) Cardiomyopathy associated with antiretroviral therapy in patients with HIV infection: a report of six cases. Ann Intern Med 116:311–313

    PubMed  CAS  Google Scholar 

  50. Herskowitz A et al (1993) Prevalence and incidence of left ventricular dysfunction in patients with human immnunodeficiency virus infection. Am J Cardiol 71:955–958

    PubMed  CAS  Google Scholar 

  51. Herskowitz A et al (1994) Myocarditis and cardiotropic viral infection associated with severe left ventricular dysfunction in late-stage infection with human immuno-deficiency virus. J Am Coll Cardiol 24:1025–1032

    PubMed  CAS  Google Scholar 

  52. Himelman RB, Dohrmann M, Goodman P et al (1989) Severe pulmonary hypertension and cor pulmonale in the acquired immunodeficiency syndrome. Am J Cardiol 64:1396

    PubMed  CAS  Google Scholar 

  53. Hsia J, Ross AM (1994) Pericardial effusion and pericardiocentesis in human immunodeficiency virus infection. Am J Cardiol 74:94–96

    PubMed  CAS  Google Scholar 

  54. Hsue PY et al (2004) Clinical features of acute coronary syndrome in patients with human immunodeficiency virus infection. Circulation 109:316–319

    PubMed  Google Scholar 

  55. Hsue PY et al (2004) Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection. Circulation 109:1603–1608

    PubMed  Google Scholar 

  56. Hunt PW, Martin JN, Sinclair E, Bredt B, Hagos E, Lampiris H, Deeks S (2003) T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 187:1534–1543

    PubMed  CAS  Google Scholar 

  57. Jung O, Bickel M, Ditting T, Rickerts V, Welk T, Helm EB, Staszewski S, Geiger H (2004) Hypertension in HIV-1-infected patients and its impact on renal and cardiovascular integrity. Nephrol Dial Transplant 19:2250–2258

    PubMed  Google Scholar 

  58. Justo D (2006) Methadone-induced long QT syndrome vs methadone-induced torsades de pointes. Arch Intern Med 166:2288

    PubMed  Google Scholar 

  59. Jutte A, Schwenk A, Franzen C, Romer K, Diet F, Diehl V, Fatkenheuer G, Salzberger B (1999) Increasing morbidity from myocardial infarction during HIV protease inhibitor treatment? AIDS 13:1796–1797

    PubMed  CAS  Google Scholar 

  60. Kanmogne GD, Primeaux C, Grammas P (2005) Induction of apoptosis and endothelin-1 secretion in primary human lung endothelial cells by HIV-1 gp120 proteins.Biochem Biophys Res Commun 333:1107

    PubMed  CAS  Google Scholar 

  61. Kannel WB, Giordano M (2004) Long-term cardiovascular risk with protease inhibitors and management of the dyslipidemia. Am J Cardiol 94:901–906

    PubMed  CAS  Google Scholar 

  62. Kaplan LD et al (2003) Case 31-2003: a 44-year old man with HIV infection and a right atrial mass. N Engl J Med 349:1369–1377

    PubMed  CAS  Google Scholar 

  63. Kelsey RC, Saker A, Morgan M (1991) Cardiac lymphoma in a patient with AIDS. Ann Intern Med 115:370

    PubMed  CAS  Google Scholar 

  64. Kim J, Ruff M, Karwatowska-Prokopczuk E et al (1998) HIV envelope protein gp120 induces neuropeptide Y receptor-mediated proliferation of vascular smooth muscle cells: relevance to AIDS cardiovascular pathogenesis. Regul Pept 75–76:201

    PubMed  Google Scholar 

  65. Kocheril A, Bokhari SAJ, Batsford WP (1997) Long QTc and torsades de pointes in human immunodeficiency virus disease. Pacing Clin Electrophysiol 20:2810

    PubMed  CAS  Google Scholar 

  66. Lebech AM, Kristoffersen US, Mehlsen J et al (2007) Autonomic dysfunction in HIV patients on antiretroviral therapy: studies of heart rate variability. Clin Physiol Funct Imaging 27:363

    PubMed  Google Scholar 

  67. Lee GA, Seneviratne T, Noor MA, Lo JC, Schwarz JM, Aweeka FT, Mulligan K, Schambelan M, Grunfeld C (2004) The metabolic effects of lopinavir/ritonavir in HIV-negative men. AIDS 18:641–649

    PubMed  CAS  Google Scholar 

  68. Leidig GA Jr (1991) Clinical, echocardiographic, and electrocardiographic resolution of HIV-related cardiomyopathy. Mil Med 156:260

    PubMed  Google Scholar 

  69. Levy WS, Simon GL, Rios JC, Ross AM (1989) Prevalence of cardiac abnormalities in human immunodeficiency virus infection. Am J Cardiol 63:86

    PubMed  CAS  Google Scholar 

  70. Lewis W, Grupp IL, Grupp G, Hoit B, Morris R, Samarel AM, Bruggeman L, Klotman P (2000) Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine. Lab Invest 80:187–197

    PubMed  CAS  Google Scholar 

  71. Libby P (2000) Imflammation in atherosclerosis. Nature 420:868–874

    Google Scholar 

  72. Little RF, Gutierrez M, Jaffe ES et al (2001) HIV-associated non-Hodgkin lymphoma: incidence, presentation, and prognosis. JAMA 285:1880

    PubMed  CAS  Google Scholar 

  73. Ly T, Ruiz ME (2007) Prolonged QT interval and torsades de pointes associated with atazanavir therapy. Clin Infect Dis 44:e67

    PubMed  Google Scholar 

  74. Martin S et al (2004) Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression. Circulation 109:1653–1659

    PubMed  Google Scholar 

  75. Mary-Krause M, Cotte L, Simon A, Partisani M, Costagliola D (2003) Increased risk of myocardial infarction with duration of protease inhibitor therapy in HIV-infected men. AIDS 17:2479–2486

    PubMed  Google Scholar 

  76. Mesa RA, Edell ES, Dunn WF, Edwards WD (1998) Human immunodeficiency virus infection and pulmonary hypertension: two new cases and a review of 86 reported cases. Mayo Clin Proc 73:37

    PubMed  CAS  Google Scholar 

  77. Miró JM, del Río A, Mestres CA (2002) Infective endocarditis in intravenous drug abusers and HIV-1 infected patients. Infect Dis Clin North Am 16:273

    PubMed  Google Scholar 

  78. Mocroft A, Vella S, Benfield TL, Chiesa A, Miller V et al (1998) Cahging patterns of mortality across Europe in patients infected with HIV-1. Lancet 352:1725–1730

    PubMed  CAS  Google Scholar 

  79. Montalbetti L, Della Volpe A, Airaghi ML et al (1999) Primary cardiac lymphoma. A case report and review. Minerva Cardioangiol 47:175

    PubMed  CAS  Google Scholar 

  80. Niaura R, Shadel WG, Morrow K, Tashima K, Flanigan T, Abrams DB (2000) Human immunodeficiency virus infection, AIDS, and smoking cessation: the time is now. Clin Infect Dis 31:808–812

    PubMed  CAS  Google Scholar 

  81. Noor MA, Lo JC, Mulligan K, Schwarz JM, Halvorsen RA, Schambelan M, Grunfeld C (2001) Metabolic effects of indinavir in healthy HIV-seronegative men. AIDS 15:F11–F18

    PubMed  CAS  Google Scholar 

  82. Ntsekhe M, Mayosi BM (2009) Cardiac manifestations of HIV infection: an African perspective. Nat Clin Pract Cardiovasc Med 6:120

    PubMed  Google Scholar 

  83. Opravil M, Pechere M, Speich R et al (1997) HIV-associated primary pulmonary hypertension. A case control study. Am J Respir Crit Care Med 155:990

    PubMed  CAS  Google Scholar 

  84. Pasceri V et al (2000) Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102:2165–2168

    PubMed  CAS  Google Scholar 

  85. Pellicelli AM, Barbaro G, Palmieri F et al (2001) Primary pulmonary hypertension in HIV patients: a systematic review. Angiology 52:31

    PubMed  CAS  Google Scholar 

  86. Periard D, Cavassini M, Taffe P et al (2008) High prevalence of peripheral arterial disease in HIV-infected persons. Clin Infect Dis 46:761

    PubMed  Google Scholar 

  87. Petitpretz P, Brenot F, Azartam R et al (1994) Pulmonary hypertension in patients with human immunodeficiency virus infection: comparison with primary pulmonary hypertension. Circulation 89:2722

    PubMed  CAS  Google Scholar 

  88. Hsue PY, Waters DD (2005) What a cardiologist needs to know about patients with human immunodeficiency virus infection. Circulation 112: 3947–3957

    PubMed  Google Scholar 

  89. Pugliese A, Gennero L, Vidotto V et al (2004) A review of cardiovascular complications accompanying AIDS. Cell Biochem Funct 22(3):137–141

    PubMed  CAS  Google Scholar 

  90. Pugliese A et al (2000) Impact of highly active antiretroviral therapy in HIV-positive patients with cardiac involvement. J Infect 40:282–284

    PubMed  CAS  Google Scholar 

  91. Purnell JQ, Zambon A, Knopp RH, Pizzuti DJ, Achari R, Leonard JM, Locke C, Brunzell JD (2000) Effect of ritonavir on lipids and post-heparin lipase activities in normal subjects. AIDS 14:51–57

    PubMed  CAS  Google Scholar 

  92. Roldan EO, Moskowitz L, Hensley GT (1987) Pathology of the heart in acquired immunodeficiency syndrome. Arch Pathol Lab Med 111:943

    PubMed  CAS  Google Scholar 

  93. Roy VP, Prabhakar S, Pulvirenti J, Mathew J (1999) Frequency and factors associated with cardiomyopathy in patients with human immunodeficiency virus infection in an inner-city hospital. J Natl Med Assoc 91:502

    PubMed  CAS  Google Scholar 

  94. Rusnati M et al (2002) HIV-1 Tat protein and endothelium: from protein/cell interaction to AIDS-associated pathologies. Angiogenesis 5:141–151

    PubMed  CAS  Google Scholar 

  95. Sadler BM, Piliero PJ, Preston SL, Lloyd PP, Lou Y, Stein DS (2001) Pharmacokinetics and safety of amprenavir and ritonavir following multiple-dose, co-administration to healthy volunteers. AIDS 15:1009–1018

    PubMed  CAS  Google Scholar 

  96. Sanne I, Piliero P, Squires K, Thiry A, Schnittman S (2003) Results of a phase 2 clinical trial at 48 weeks (AI424-007): a dose-ranging, safety, and efficacy comparative trial of atazanavir at three doses in combination with didanosine and stavudine in antiretroviral-naive subjects. J Acquir Immune Defic Syndr 32:18–29

    PubMed  CAS  Google Scholar 

  97. Schuster M, Valentine F, Holzman R (1985) Cryptococcal pericarditis in an intravenous drug abuser. J Infect Dis 152:842

    PubMed  CAS  Google Scholar 

  98. Shannon RP, Mathier MA, Manleod S et al (1999) Macrophages not cardiomyocytes are the reservoir for lentivirus in SIV cardiomyopathy. Circulation 100:1

    Google Scholar 

  99. Shen YM, Frenkel EP (2004) Thrombosis and a hypercoagulable state in HIV-infected patients. Clin Appl Thromb Hemost 10:277–280

    PubMed  Google Scholar 

  100. Silva-Cardoso J, Moura B, Ferreira A et al (1998) Predictors of myocardial dysfunction in human immunodeficiency virus-infected patients. J Card Fail 4:19

    PubMed  CAS  Google Scholar 

  101. Sitbon O et al (2004) Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension. Am J Respir Crit Care Med 170:1212–1217

    PubMed  Google Scholar 

  102. Speich R, Jenni R, Opravil M et al (1991) Primary pulmonary hypertension and HIV infection. Chest 100:1268

    PubMed  CAS  Google Scholar 

  103. Stahl CP, Wideman CS, Spira TJ, Haff EC, Hixon GJ, Evatt BL (1993) Protein S deficiency in men with long-term human immunodeficiency virus infection. Blood 81:1801–1807

    PubMed  CAS  Google Scholar 

  104. Stein JH et al (2001) Use of Human immunodeficiency virus-1 protease inhibitors is associated with atherogenic lipoprotein changes and endothelial dysfunction. Circulation 104:257–262

    PubMed  CAS  Google Scholar 

  105. Stotka JL, Good CB, Downer WR, Kapoor WN (1989) Pericardial effusion and Pericardial effusion and tamponade due to Kaposi’s sarcoma in acquired immunodeficiency syndrome. Chest 95:1359

    PubMed  CAS  Google Scholar 

  106. Sturm A, Noppeney R, Reimer J et al (2001) AIDS and non-Hodgkin’s lymphoma: initial cardiac manifestations of highly malignant B-cell lymphoma 18 years after HIV infection. Dtsch Med Wochenschr 126:364

    PubMed  CAS  Google Scholar 

  107. Tershakovec AM, Frank I, Rader D (2004) HIV-related lipodystrophy and related factors. Atherosclerosis 174(1):1–10

    PubMed  CAS  Google Scholar 

  108. Trachiotis GD et al (2003) Cardiac surgery in patients infected with the human immunodeficiency virus. Ann Thorac Surg 76:1114–1118

    PubMed  Google Scholar 

  109. Villa Foresti V, Confaloneri F (1995) Autonomic neuropathy and prolongation of the QT interval in human immunodeficiency virus infection. Clin Auton Res 5:48

    Google Scholar 

  110. Wafaa E-S, Reiss P, De Wit S, Monforte AD, Thiebaut R, Morfeld L, Weber R, Pradier C, Calvo G, Law M, Kirk O, Sabin C, Friis-Moller N, Lundgren J (2005) Relationship between prolonged exposure to combination art and myocardial infarction: effect of sex, age, and lipid changes. In: Program and abstracts of the 12th conference on retroviruses and opportunistic infections; 22-25 February 2005, Boston. Abstract 42

    Google Scholar 

  111. Wlodarczyk D (2004) Managing medical conditions associated with cardiac risk in patients with HIV. In: Peiperl L, Volberding PA (eds) HIV insite knowledge base [textbook online]. UCSF Center for HIV Information, San Francisco. Available at: http://hivinsite.ucsf.edu/InSite?page=kb-03-01-20#S2.3X.

  112. Zhou X, Nicoletti A, Elhage R, Hansson GK (2000) Transfer of CD4+ T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice. Circulation 102:2919–2922

    PubMed  CAS  Google Scholar 

  113. Zwaka TP et al (2001) C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis. Circulation 103:1194–1197

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Raluca Arimie .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Arimie, R., Movahedi, Z. (2010). Evidence-Based Decisions in Human Immunodeficiency Virus Infection and Cardiac Disease. In: Chiappelli, F. (eds) Evidence-Based Practice: Toward Optimizing Clinical Outcomes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05025-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-05025-1_6

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05024-4

  • Online ISBN: 978-3-642-05025-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics