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APC, T Cells, and the Immune Synapse

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Immunological Synapse

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 340))

Abstract

CD4+ T cells engage different activating cells during their generation in the bone marrow and thymus and during their homeostasis and activation in the periphery. During these processes, T cells or their precursors establish a molecular platform for communication in the interface between the two cells that is called immune synapse (IS). Here we review the current knowledge about those different IS. Apart from looking at the structure and signalling of the IS from the T cell region, we will also focus on the area of the IS partner, mostly antigen-presenting cells (APC). We will discuss the features of different APC and their role played in the control of the resulting activated or differentiated T cell. We will also demonstrate that despite 10 years of research into the subject, large areas of this field are yet to be explored. This will keep us busy for the years to come – new exciting results lie ahead of us.

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References

  • Adams GB, Scadden DT (2006) The hematopoietic stem cell in its place. Nat Immunol 7:333–337

    CAS  PubMed  Google Scholar 

  • Al-Alwan MM, Rowden G, Lee TD, West KA (2001) Cutting edge: the dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J Immunol 166:1452–1456

    CAS  PubMed  Google Scholar 

  • Al-Alwan MM, Liwski RS, Haeryfar SM, Baldridge WH, Hoskin DW, Rowden G, West KA (2003) Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent. J Immunol 171:4479–4483

    CAS  PubMed  Google Scholar 

  • Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245–254

    CAS  PubMed  Google Scholar 

  • Benz C, Martins VC, Radtke F, Bleul CC (2008) The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J Exp Med 205:1187–1199

    CAS  PubMed  Google Scholar 

  • Boehm T, Bleul CC (2006) Thymus-homing precursors and the thymic microenvironment. Trends Immunol 27:477–484

    CAS  PubMed  Google Scholar 

  • Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM (2002) Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8(+) T cell tolerance. J Exp Med 196:1627–1638

    CAS  PubMed  Google Scholar 

  • Bos JL, de RJ, Reedquist KA (2001) Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol 2:369–377

    CAS  PubMed  Google Scholar 

  • Bousso P, Bhakta NR, Lewis RS, Robey E (2002) Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 296:1876–1880

    CAS  PubMed  Google Scholar 

  • Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Forster R (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192:1545–1552

    CAS  PubMed  Google Scholar 

  • Brocker T (1997) Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class-II expressing dendritic cells. J Exp Med 186:1223–1232

    CAS  PubMed  Google Scholar 

  • Bromley SK, Burack WR, Johnson KG, Somersalo K, Sims TN, Sumen C, Davis MM, Shaw AS, Allen PM, Dustin ML (2001) The immunological synapse. Annu Rev Immunol 19:375–396

    CAS  PubMed  Google Scholar 

  • Brossard C, Feuillet V, Schmitt A, Randriamampita C, Romao M, Raposo G, Trautmann A (2005) Multifocal structure of the T cell – dendritic cell synapse. Eur J Immunol 35:1741–1753

    CAS  PubMed  Google Scholar 

  • Bryce PJ, Miller ML, Miyajima I, Tsai M, Galli SJ, Oettgen HC (2004) Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity 20:381–392

    CAS  PubMed  Google Scholar 

  • Casamayor-Palleja M, Mondiere P, Verschelde C, Bella C, Defrance T (2002) BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentially. Blood 99:1913–1921

    CAS  PubMed  Google Scholar 

  • Celli S, Lemaitre F, Bousso P (2007) Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation. Immunity 27:625–634

    CAS  PubMed  Google Scholar 

  • Celso CL, Fleming HE, Wu JW, Zhao CX, Miake-Lye S, Fujisaki J, Cote D, Rowe DW, Lin CP, Scadden DT (2008) Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature 457:92–96. doi:10.1038/nature07434

    PubMed  Google Scholar 

  • Cemerski S, Das J, Giurisato E, Markiewicz MA, Allen PM, Chakraborty AK, Shaw AS (2008) The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity 29:414–422

    CAS  PubMed  Google Scholar 

  • Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL (2007) Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 315:1687–1691

    CAS  PubMed  Google Scholar 

  • Delaguillaumie A, Marin-Esteban V, Setterblad N, Leh LJ, Assier E, Gelin C, Charron D, Galy A, Mooney N (2008) Contrasting cytoskeletal regulation of MHC class II peptide presentation by human B cells or dendritic cells. Eur J Immunol 38:1096–1105

    CAS  PubMed  Google Scholar 

  • Dustin ML (2008) T-cell activation through immunological synapses and kinapses. Immunol Rev 221:77–89

    CAS  PubMed  Google Scholar 

  • Ebert PJ, Ehrlich LI, Davis MM (2008) Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation. Immunity 29:734–745

    CAS  PubMed  Google Scholar 

  • Egen JG, Allison JP (2002) Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 16:23–35

    CAS  PubMed  Google Scholar 

  • Egen JG, Rothfuchs AG, Feng CG, Winter N, Sher A, Germain RN (2008) Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. Immunity 28:271–284

    CAS  PubMed  Google Scholar 

  • Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM (2002) Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity 17:809–822

    CAS  PubMed  Google Scholar 

  • Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR (2008) Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc Natl Acad Sci USA 105:19396–19401

    CAS  PubMed  Google Scholar 

  • Fos C, Salles A, Lang V, Carette F, Audebert S, Pastor S, Ghiotto M, Olive D, Bismuth G, Nunes JA (2008) ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse. J Immunol 181:1969–1977

    CAS  PubMed  Google Scholar 

  • Friedl P, den Boer AT, Gunzer M (2005) Tuning immune responses: diversity and adaption of the immunological synapse. Nat Rev Immunol 5:532–545

    CAS  PubMed  Google Scholar 

  • Geiger H, Koehler A, Gunzer M (2007) Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging. Cell Cycle 6:884–887

    CAS  PubMed  Google Scholar 

  • Germain RN (2002) T-cell development and the CD4-CD8 lineage decision. Nat Rev Immunol 2:309–322

    CAS  PubMed  Google Scholar 

  • Gondek DC, Lu LF, Quezada SA, Sakaguchi S, Noelle RJ (2005) Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol 174:1783–1786

    CAS  PubMed  Google Scholar 

  • Goodnow CC, Cyster JG (1997) Lymphocyte homing: the scent of a follicle. Curr Biol 7:R219–R222

    CAS  PubMed  Google Scholar 

  • Goodnow CC, Sprent J, Fazekas de St GB, Vinuesa CG (2005) Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 435:590–597

    CAS  PubMed  Google Scholar 

  • Grakoui A, Bromley SK, Sumen C, Davis MM, Shaw AS, Allen PM, Dustin ML (1999) The immunological synapse: a molecular machine controlling T cell activation. Science 285:221–227

    CAS  PubMed  Google Scholar 

  • Gunsilius E, Gastl G, Petzer AL (2001) Hematopoietic stem cells. Biomed Pharmacother 55:186–194

    CAS  PubMed  Google Scholar 

  • Gunzer M (2007) Migration, cell-cell interaction and adhesion in the immune system. Earnst Schering Found Symp Proc 3:97–137

    Google Scholar 

  • Gunzer M, Schäfer A, Borgmann S, Grabbe S, Zänker KS, Bröcker E-B, Kämpgen E, Friedl P (2000) Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13:323–332

    CAS  PubMed  Google Scholar 

  • Gunzer M, Weishaupt C, Hillmer A, Basoglu Y, Friedl P, Dittmar KE, Kolanus W, Varga G, Grabbe S (2004) A spectrum of biophysical interaction modes between T cells and different antigen presenting cells during priming in 3-D collagen and in vivo. Blood 104:2801–2809

    CAS  PubMed  Google Scholar 

  • Habicht A, Najafian N, Yagita H, Sayegh MH, Clarkson MR (2007) New insights in CD28-independent allograft rejection. Am J Transplant 7:1917–1926

    CAS  PubMed  Google Scholar 

  • Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY (2004) Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21:267–277

    CAS  PubMed  Google Scholar 

  • Huster KM, Busch V, Schiemann M, Linkemann K, Kerksiek KM, Wagner H, Busch DH (2004) Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc Natl Acad Sci USA 101:5610–5615

    CAS  PubMed  Google Scholar 

  • Itano AA, McSorley SJ, Reinhardt RL, Ehst BD, Ingulli E, Rudensky AY, Jenkins MK (2003) Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19:47–57

    CAS  PubMed  Google Scholar 

  • Kamperschroer C, Roberts DM, Zhang Y, Weng NP, Swain SL (2008) SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation. J Immunol 181:3994–4003

    CAS  PubMed  Google Scholar 

  • Kato H, Kojima H, Ishii N, Hase H, Imai Y, Fujibayashi T, Sugamura K, Kobata T (2004) Essential role of OX40L on B cells in persistent alloantibody production following repeated alloimmunizations. J Clin Immunol 24:237–248

    CAS  PubMed  Google Scholar 

  • Kim MY, Gaspal FM, Wiggett HE, McConnell FM, Gulbranson-Judge A, Raykundalia C, Walker LS, Goodall MD, Lane PJ (2003) CD4(+)CD3(−) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells. Immunity 18:643–654

    CAS  PubMed  Google Scholar 

  • Kopp HG, Avecilla ST, Hooper AT, Rafii S (2005) The bone marrow vascular niche: home of HSC differentiation and mobilization. Physiology (Bethesda) 20:349–356

    CAS  Google Scholar 

  • Krall WJ, Braun J (1992) In vivo retroviral marking of antigen-specific B lymphocytes. Semin Immunol 4:19–28

    CAS  PubMed  Google Scholar 

  • Krummel MF, Sjaastad MD, Wulfing C, Davis MM (2000) Differential clustering of CD4 and CD3 zeta during T cell recognition. Science 289:1349–1352

    CAS  PubMed  Google Scholar 

  • Lassila O, Vainio O, Matzinger P (1988) Can B cells turn on virgin T cells? Nature 334:253–255

    CAS  PubMed  Google Scholar 

  • Lee KH, Holdorf AD, Dustin ML, Chan AC, Allen PM, Shaw AS (2002) T cell receptor signaling precedes immunological synapse formation. Science 295:1539–1542

    CAS  PubMed  Google Scholar 

  • Lee KH, Dinner AR, Tu C, Campi G, Raychaudhuri S, Varma R, Sims TN, Burack WR, Wu H, Wang J, Kanagawa O, Markiewicz M, Allen PM, Dustin ML, Chakraborty AK, Shaw AS (2003) The immunological synapse balances T cell receptor signaling and degradation. Science 302:1218–1222

    CAS  PubMed  Google Scholar 

  • Letschka T, Kollmann V, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Obermair GJ, Fresser F, Leitges M, Hermann-Kleiter N, Kaminski S, Baier G (2008) PKC-theta selectively controls the adhesion-stimulating molecule Rap1. Blood 112:4617–4627

    CAS  PubMed  Google Scholar 

  • Lind EF, Prockop SE, Porritt HE, Petrie HT (2001) Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J Exp Med 194:127–134

    CAS  PubMed  Google Scholar 

  • Linton PJ, Bautista B, Biederman E, Bradley ES, Harbertson J, Kondrack RM, Padrick RC, Bradley LM (2003) Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. J Exp Med 197:875–883

    CAS  PubMed  Google Scholar 

  • Lo CG, Xu Y, Proia RL, Cyster JG (2005) Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med 201:291–301

    CAS  PubMed  Google Scholar 

  • Maldonado RA, Irvine DJ, Schreiber R, Glimcher LH (2004) A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431:527–532

    CAS  PubMed  Google Scholar 

  • Marsland BJ, Kopf M (2008) T-cell fate and function: PKC-theta and beyond. Trends Immunol 29:179–185

    CAS  PubMed  Google Scholar 

  • Masten BJ, Lipscomb MF (1999) Comparison of lung dendritic cells and B cells in stimulating naive antigen-specific T cells. J Immunol 162:1310–1317

    CAS  PubMed  Google Scholar 

  • Matzinger P (2002) The danger model: a renewed sense of self. Science 296:301–305

    CAS  PubMed  Google Scholar 

  • Mempel TR, Henrickson SE, von Andrian UH (2004) T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427:154–159

    CAS  PubMed  Google Scholar 

  • Miller MJ, Safrina O, Parker I, Cahalan MD (2004) Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J Exp Med 200:847–856

    CAS  PubMed  Google Scholar 

  • Monks CR, Kupfer H, Tamir I, Barlow A, Kupfer A (1997) Selective modulation of protein kinase C-theta during T-cell activation. Nature 385:83–86

    CAS  PubMed  Google Scholar 

  • Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A (1998) Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82–86

    CAS  PubMed  Google Scholar 

  • M’Rini C, Cheng G, Schweitzer C, Cavanagh LL, Palframan RT, Mempel TR, Warnock RA, Lowe JB, Quackenbush EJ, von Andrian UH (2003) A novel endothelial L-selectin ligand activity in lymph node medulla that is regulated by alpha(1, 3)-fucosyltransferase-IV. J Exp Med 198:1301–1312

    PubMed  Google Scholar 

  • Muranski P, Chmielowski B, Ignatowicz L (2000) Mature CD4+ T cells perceive a positively selecting class II MHC/peptide complex in the periphery. J Immunol 164:3087–3094

    CAS  PubMed  Google Scholar 

  • Nilsson SK, Johnston HM, Coverdale JA (2001) Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches. Blood 97:2293–2299

    CAS  PubMed  Google Scholar 

  • Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C (2008) Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29:138–149

    CAS  PubMed  Google Scholar 

  • Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, O’Garra A, Cahalan MD, Cyster JG (2005) Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 3:e150

    PubMed  Google Scholar 

  • Onishi Y, Fehervari Z, Yamaguchi T, Sakaguchi S (2008) Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci USA 105:10113–10118

    CAS  PubMed  Google Scholar 

  • Osawa M, Hanada K, Hamada H, Nakauchi H (1996) Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273:242–245

    CAS  PubMed  Google Scholar 

  • Pentcheva-Hoang T, Egen JG, Wojnoonski K, Allison JP (2004) B7-1 and b7-2 selectively recruit ctla-4 and CD28 to the immunological synapse. Immunity 21:401–413

    CAS  PubMed  Google Scholar 

  • Qi H, Cannons JL, Klauschen F, Schwartzberg PL, Germain RN (2008) SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455:764–769

    CAS  PubMed  Google Scholar 

  • Reichardt P, Dornbach B, Gunzer M (2007a) The molecular makeup and function of regulatory and effector synapses. Immunol Rev 218:165–177

    CAS  PubMed  Google Scholar 

  • Reichardt P, Dornbach B, Song R, Beissert S, Gueler F, Loser K, Gunzer M (2007b) Naive B cells generate regulatory T cells in the presence of a mature immunological synapse. Blood 110:1519–1529

    CAS  PubMed  Google Scholar 

  • Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002) Balanced responsiveness to chemoattractants from adjacent zones determines B cell position. Nature 416:94–99

    PubMed  Google Scholar 

  • Richie LI, Ebert PJ, Wu LC, Krummel MF, Owen JJ, Davis MM (2002) Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection. Immunity 16:595–606

    CAS  PubMed  Google Scholar 

  • Rudd CE, Schneider H (2003) Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol 3:544–556

    CAS  PubMed  Google Scholar 

  • Sanchez-Lockhart M, Graf B, Miller J (2008) Signals and sequences that control CD28 localization to the central region of the immunological synapse. J Immunol 181:7639–7648

    CAS  PubMed  Google Scholar 

  • Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol 2:434–441

    CAS  PubMed  Google Scholar 

  • Scadden DT (2006) The stem-cell niche as an entity of action. Nature 441:1075–1079

    CAS  PubMed  Google Scholar 

  • Schmitt TM, Zuniga-Pflucker JC (2002) Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17:749–756

    CAS  PubMed  Google Scholar 

  • Scholer A, Hugues S, Boissonnas A, Fetler L, Amigorena S (2008) Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity 28:258–270

    CAS  PubMed  Google Scholar 

  • Seminario MC, Bunnell SC (2008) Signal initiation in T-cell receptor microclusters. Immunol Rev 221:90–106

    CAS  PubMed  Google Scholar 

  • Serra P, Amrani A, Yamanouchi J, Han B, Thiessen S, Utsugi T, Verdaguer J, Santamaria P (2003) CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells. Immunity 19:877–889

    CAS  PubMed  Google Scholar 

  • Shakhar G, Lindquist RL, Skokos D, Dudziak D, Huang JH, Nussenzweig MC, Dustin ML (2005) Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol 6:707–714

    CAS  PubMed  Google Scholar 

  • Shevach EM, Dipaolo RA, Andersson J, Zhao DM, Stephens GL, Thornton AM (2006) The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol Rev 212:60–73

    CAS  PubMed  Google Scholar 

  • Sixt M, Kanazawa N, Selg M, Samson T, Roos G, Reinhardt DP, Pabst R, Lutz MB, Sorokin L (2005) The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22:19–29

    CAS  PubMed  Google Scholar 

  • Spangrude GJ, Scollay R (1990) Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny. J Immunol 145:3661–3668

    CAS  PubMed  Google Scholar 

  • Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301–314

    CAS  PubMed  Google Scholar 

  • Stamper HB Jr, Woodruff JJ (1976) Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules. J Exp Med 144:828–833

    PubMed  Google Scholar 

  • Stefanova I, Dorfman JR, Germain RN (2002) Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420:429–434

    CAS  PubMed  Google Scholar 

  • Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449:419–426

    CAS  PubMed  Google Scholar 

  • Sumoza-Toledo A, Eaton AD, Sarukhan A (2006) Regulatory T cells inhibit protein kinase C theta recruitment to the immune synapse of naive T cells with the same antigen specificity. J Immunol 176:5779–5787

    CAS  PubMed  Google Scholar 

  • Tai X, Cowan M, Feigenbaum L, Singer A (2005) CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol 6:152–162

    CAS  PubMed  Google Scholar 

  • Tan JB, Visan I, Yuan JS, Guidos CJ (2005) Requirement for Notch1 signals at sequential early stages of intrathymic T cell development. Nat Immunol 6:671–679

    CAS  PubMed  Google Scholar 

  • Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA (2004) Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur J Immunol 34:2996–3005

    CAS  PubMed  Google Scholar 

  • Tseng SY, Waite JC, Liu M, Vardhana S, Dustin ML (2008) T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase Ctheta. J Immunol 181:4852–4863

    CAS  PubMed  Google Scholar 

  • Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM, Yu D, Domaschenz H, Whittle B, Lambe T, Roberts IS, Copley RR, Bell JI, Cornall RJ, Goodnow CC (2005) A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435:452–458

    CAS  PubMed  Google Scholar 

  • Visan I, Tan JB, Yuan JS, Harper JA, Koch U, Guidos CJ (2006a) Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol 7:634–643

    CAS  PubMed  Google Scholar 

  • Visan I, Yuan JS, Tan JB, Cretegny K, Guidos CJ (2006b) Regulation of intrathymic T-cell development by Lunatic Fringe-Notch1 interactions. Immunol Rev 209:76–94

    CAS  PubMed  Google Scholar 

  • von Andrian UH, Mempel TR (2003) Homing and cellular traffic in lymph nodes. Nat Rev Immunol 3:867–878

    Google Scholar 

  • von Boehmer H, Aifantis I, Gounari F, Azogui O, Haughn L, Apostolou I, Jaeckel E, Grassi F, Klein L (2003) Thymic selection revisited: how essential is it? Immunol Rev 191:62–78

    Google Scholar 

  • Watson AR, Lee WT (2004) Differences in signaling molecule organization between naive and memory CD4+ T lymphocytes. J Immunol 173:33–41

    CAS  PubMed  Google Scholar 

  • Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD (2005) Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol 6:1228–1235

    CAS  PubMed  Google Scholar 

  • Wilson A, Trumpp A (2006) Bone-marrow haematopoietic stem-cell niches. Nat Rev Immunol 6:93–106

    CAS  PubMed  Google Scholar 

  • Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S (2008) CTLA-4 control over Foxp3+ regulatory T cell function. Science 322:271–275

    CAS  PubMed  Google Scholar 

  • Witmer-Pack MD, Swiggard WJ, Mirza A, Inaba K, Steinman RM (1995) Tissue distribution of the DEC-205-protein is detected by the monoclonal antibody NLDC-145. II. Expression in situ in lymphoid and nonlymphoid tissues. Cell Immunol 163:157–162

    CAS  PubMed  Google Scholar 

  • Wu M, Hyog YK, Rattis F, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T, Reya T (2007) Imaging hematopoietic precursor division in real time. Cell Stem Cell 1:541–554

    CAS  PubMed  Google Scholar 

  • Yokosuka T, Kobayashi W, Sakata-Sogawa K, Takamatsu M, Hashimoto-Tane A, Dustin ML, Tokunaga M, Saito T (2008) Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity 29:589–601

    CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by research grants from the German Research Community (DFG, GU769/1-3, GU769/2-1) and the European Union (EU Nest, Mamocell) to M.G.

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Authors and Affiliations

  1. Otto-von-Guericke University, Institute of Molecular and Clinical Immunology, Leipziger Str. 44, D-39120, Magdeburg, Germany

    Peter Reichardt & Matthias Gunzer

  2. Helmholtz Centre for Infection Research, Inhoffenstr. 7, D-38124, Braunschweig, Germany

    Bastian Dornbach

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  1. Peter Reichardt
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  2. Bastian Dornbach
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Correspondence to Matthias Gunzer .

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  1. Allergy & Immunology, RIKEN Research Center for, Suehiro-cho 1-7-22, okohama City, Kanagawa, 230-0045, Japan

    Takashi Saito

  2. London Research Institute, Cancer Research UK, Lincoln's Inn Fields 44, London, WC2A 3PX, United Kingdom

    Facundo D. Batista

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Reichardt, P., Dornbach, B., Gunzer, M. (2010). APC, T Cells, and the Immune Synapse. In: Saito, T., Batista, F. (eds) Immunological Synapse. Current Topics in Microbiology and Immunology, vol 340. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03858-7_12

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